Injection
Lipo-B
A lipotropic blend of methionine, inositol, choline and B12 that supports how the liver processes fat, as part of a weight-loss plan. Prescribed and dosed by a licensed physician.
Starting at $109/mo
EnergyB12
Vitamin B12 Injection
RxPrescription onlyInjected under the skin · Twice a week · 1 mL, 1000 mcg · Energy · B12
Starting at $109/mo
The classic vitamin B12 (cyanocobalamin) injection to restore low B12 and support energy, focus and red blood cell health, bypassing the gut entirely.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Restores B12 fully even when the gut absorbs it poorly
- Supports energy, focus, nerve function and red blood cells
- Weekly or monthly injection, dosed by your physician
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is the vitamin B12 injection?
(cyanocobalamin)
Vitamin B12 is needed to make red blood cells, protect nerves and run the chemistry that turns food into energy. Absorbing it from food depends on stomach acid and a protein called intrinsic factor, both of which fall with age, acid-reducing medication, metformin, and gut conditions. An injection delivers B12 straight into the muscle, so none of that matters. Cyanocobalamin is the most studied and most stable form.
- How it is taken
- Injected under the skin
- How often
- Twice a week
- Dose range
- 1 mL, 1000 mcg
- Form
- Energy · B12
1 in 6
adults over 60 have low or borderline B12, according to the clinical review in the New England Journal of Medicine
B12 injections are well established for deficiency. For people with normal levels, extra B12 does not add energy; your physician checks your level first.
How it works,
week by week.
Day 1
A US-licensed physician reviews your symptoms, history and, when needed, your B12 level, and chooses the injection and schedule. The kit includes everything you need.
Week 1
A small intramuscular or subcutaneous injection, weekly to start. It takes under a minute; most people do it at home without trouble.
Weeks 2–4
If your B12 was low, energy, focus and tingling usually start improving here as stores refill.
Months 2–3
Your physician checks in, rechecks a level if needed, and stretches the interval or adjusts the blend to match your plan.
Beyond
Injections support the plan; food, movement and sleep do the work. Your physician helps you decide how long to continue.
What you may notice,
and when.
Steadier energy
the most common change members report
Clearer focus
especially when B12 was low to begin with
Support during weight loss
lipotropic blends alongside a real plan
Nerve and blood health
B12's core job
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Vitamin B12 and lipotropic injections are generally well tolerated. The most common effects are mild: soreness, redness or a small bruise at the injection site, and occasionally mild nausea, headache or a fishy body odor from choline in larger doses. B12 is water-soluble and excess is excreted. Rarely, injectable B12 can cause an allergic reaction, and it can lower potassium in the first days of correcting a severe deficiency. Not for people with cobalt allergy or Leber's disease (B12) or with a known allergy to any component. Lipotropic blends are not a substitute for a weight-loss plan and are not prescribed during pregnancy or breastfeeding without a specific reason. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Tell your physician about every medication you take, especially metformin, acid reducers and blood thinners.
The research behind
vitamin B12.
Vitamin B12 is well established for correcting deficiency. The question of oral versus injected B12 has been tested in only a few small trials.
- Oral vs injectionSimilar in small trials
The Cochrane review updated in 2018 found three randomized trials with 153 people with deficiency, comparing oral and intramuscular B12. The trials were too few and too varied for meta-analysis, and the authors call for larger, better-blinded trials.
Cochrane Database Syst Rev, Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency (CD004655.pub3) - Earlier reviewTwo trials, small
The 2005 version of the same review included two small trials, followed for three to four months.
Cochrane Database Syst Rev (CD004655.pub2) - PracticeOral rarely used
The review notes that oral B12 is rarely prescribed outside Sweden and Canada, and that case-control and case-series studies had reported equal efficacy.
Vitamin B12 review summary, American Family Physician 2006
What the studies found
- Corrects vitamin B12 deficiency; this is the established use (NIH Office of Dietary Supplements, vitamin B12 fact sheet)
- Oral and injected B12 looked similar in deficient people in three small trials (Cochrane, CD004655, 2018)
- Case-control and case-series studies reported equal efficacy of oral B12 (summarized in the American Family Physician review, 2006)
Vitamin B12 as cyanocobalamin is a standard supplement. The trials compared oral and injected B12 in people who were already deficient, not in people with normal levels.
What this does not say
- The evidence is for correcting deficiency, not for energy or weight in people with normal levels.
- The comparison rests on three small randomized trials.
- Route choice in deficiency is a clinical decision.
The research
behind it.
The New England Journal of Medicine's clinical review describes B12 deficiency as common, often missed, and fully correctable with injections that bypass absorption problems.
A 2021 systematic review found B12 supplementation improves fatigue and cognitive symptoms mainly in people who were deficient; that is why your physician checks your level before prescribing.
NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Vitamin B12?
Injected under the skin, twice a week. The starting prescription is 100 units (1 mL, 1000 mcg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Will B12 give me more energy?
If your B12 is low or borderline, yes: fatigue, brain fog and tingling improve as levels recover, often within weeks. If your level is normal, extra B12 does not add energy. That is why we ask about your history and, when needed, check a level before prescribing.
How do I inject it?
Usually into the muscle of the upper arm or thigh, or under the skin of the abdomen, once a week to start; your physician shows you and sets the schedule. The kit includes everything.
What are the side effects?
Mostly mild: soreness or a small bruise where you inject, occasional nausea or headache, and with larger choline doses a fishy odor. Serious reactions are rare. Read the safety information above and tell your physician about every medication.
Do I need a blood test?
For B12, often yes: a level tells your physician whether you are deficient and how often you need injections. For lipotropic blends alongside a weight-loss plan, your physician decides from your history. Tests can be arranged locally.
Vitamin B12 educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Injection
Lipo-C
A lipotropic blend with L-carnitine alongside methionine and inositol to support fat metabolism and energy during weight loss. Prescribed and dosed by a licensed physician.
Starting at $109/mo
Injection
MIC / B12
Methionine, inositol and choline (MIC) with vitamin B12 in one weekly injection to support metabolism alongside a weight-loss plan. Prescribed and dosed by a licensed physician.
Starting at $109/mo
Injection
MICC / B12
MIC plus L-carnitine (MICC) with vitamin B12, a lipotropic blend for fat metabolism and energy during weight loss. Prescribed and dosed by a licensed physician.
Starting at $109/mo
References
- 1.Clinical practice: vitamin B12 deficiency. N Engl J Med, 2013
- 2.Effects of vitamin B12 supplementation on cognitive function, depressive symptoms and fatigue: a systematic review. Nutrients, 2021
- 3.Efficacy of different routes of vitamin B12 supplementation for the treatment of deficiency. Ir J Med Sci, 2024
- 4.Effects of L-carnitine supplementation on weight loss and body composition: systematic review and meta-analysis of 37 randomized trials. Clin Nutr ESPEN, 2020
- 5.Choline bioavailability, liver fat metabolism and the gut microbiota. Nutrients, 2020
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.