Injection
Glutathione Injection
A master antioxidant that supports your body's natural detox pathways, skin clarity and recovery. Prescribed and dosed by a licensed clinician.
Starting at $99/mo
Energy & focusHealthy aging
NAD+ Injection
RxPrescription onlyInjected under the skin · 5 days a week · 20–50 mg · Energy & focus · Healthy aging
Starting at $159/mo
Boost energy, improve focus, and support cellular health with one of the most effective ways to restore depleted NAD+ levels, for a fraction of the cost of IV infusions.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Members commonly report more energy and sharper focus
- Injection delivers NAD+ directly, bypassing digestion
- Supports the cellular processes behind energy, DNA repair and healthy aging
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is NAD+?
(nicotinamide adenine dinucleotide)
NAD+ is a vital coenzyme found in every cell, essential for everything from energy metabolism to DNA repair. As we age, levels decline, which may contribute to fatigue, brain fog, and slower recovery. Restoring NAD+ gives your cells back the fuel they run on.
- How it is taken
- Injected under the skin
- How often
- 5 days a week
- Dose range
- 20–50 mg
- Form
- Energy & focus · Healthy aging
How it works,
week by week.
Day 1
In the first hours, NAD+ begins activating the cellular programs behind mitochondrial energy production and antioxidant support, laying the foundation for benefits that build.
30 Days
Many people notice steadier energy through the day and clearer focus as NAD+ levels rebuild.
3 Months
Physical endurance and recovery are usually clearer by now. Your physician reviews your plan and adjusts the dose.
6 Months
Sleep, mood and mental clarity changes tend to consolidate with consistent use.
1 Year and Beyond
A maintenance dose keeps levels steady. Most members settle on one or two injections a week.
What you may notice,
and when.
More energy
the most common change members report in their first weeks
More endurance
for training, long days and recovery
Mental clarity
sharper focus and less brain fog
Healthy aging
supports the repair and energy pathways that decline with age
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Injectable NAD+ is generally well tolerated. Common, mild effects include redness or bruising at the injection site, a warm flush, nausea, headache or fatigue that passes in hours; injecting slowly and staying hydrated helps. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Tell your physician if you are pregnant or breastfeeding, have heart, kidney or liver disease, or take medications for blood pressure or blood sugar.
The research behind
NAD+.
NAD+ is a coenzyme in energy metabolism. Human trials have used oral precursors (NMN and nicotinamide riboside); IV NAD+ has one tiny pharmacokinetic pilot and no controlled outcome trial.
- NMN trialmuscle insulin sensitivity
In 25 prediabetic postmenopausal women, 250 mg of NMN a day for 10 weeks raised muscle insulin sensitivity against placebo (12 on placebo, 13 on NMN). Blood glucose, blood pressure and liver fat did not change.
Yoshino et al., Science 2021 - Nicotinamide ribosideblood NAD+ about 60% higher
In 30 healthy middle-aged and older adults, 500 mg twice a day for 6 weeks, against placebo in a crossover design, raised NAD+ in blood cells by about 60%. It was well tolerated. This is a marker of NAD+ metabolism, not a health outcome.
Martens et al., Nat Commun 2018 - IV NAD+one pilot, 11 men
A six-hour infusion at about 2 mg a minute (8 men given NAD+, 3 controls). Plasma NAD+ did not change until after two hours. The pilot measured where the infused NAD+ went and measured no health outcome.
Grant et al., Front Aging Neurosci 2019
What the studies found
- Raised muscle insulin sensitivity in prediabetic postmenopausal women after 10 weeks of NMN, not on placebo (Yoshino et al., Science 2021).
- Raised NAD+ in blood cells of healthy middle-aged and older adults. This is a marker, not a proven health gain (Martens et al., Nat Commun 2018).
- Nominally better gait speed and left-hand grip in 42 healthy older men after NMN, which the authors say needs larger trials (Igarashi et al., npj Aging 2022).
The NMN and riboside trials were small and used oral precursors, not the injected NAD+ sold here. One riboside trial in 40 men with obesity found no improvement in insulin sensitivity, so the benefits above do not repeat across studies. Clinic claims of rapid plasma rises are not supported by the one IV pilot, which was not a treatment study.
What this does not say
- No randomized trial of IV or subcutaneous NAD+ with a clinical outcome was found.
- The oral precursor trials are small (25 to 42 people) and measured blood or muscle markers; they do not show that general health improves.
- A 2025 systematic review and meta-analysis of NMN and riboside trials in older adults found no support for preserving muscle mass or function.
- Long-term safety of repeated NAD+ injections is not established.
The research
behind it.
NAD+ is a critical molecule essential for cellular functions, including energy production, DNA repair, inflammation control, and circadian rhythm. Our natural NAD+ levels decline with age, which research links to changes in energy, metabolism and skin health.
Low NAD+ levels are associated with fatigue, insulin resistance, frailty and age-related decline. Studies of NAD+ restoration in adults suggest it may support healthy aging and quality of life. Injections deliver NAD+ directly, without the loss that happens in the digestive tract.
NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use NAD+?
Injected under the skin, 5 days a week. The starting prescription is 20 units (20 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does NAD+ come in?
The pharmacy carries 2: 100 mg/mL, 200 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How does NAD+ support healthy aging?
NAD+ powers the enzymes that produce cellular energy and repair DNA, and it declines with age. Restoring levels gives those systems the coenzyme they depend on, which is why NAD+ is one of the most studied molecules in longevity research.
Why injections instead of oral NAD+ or supplements?
NAD+ taken by mouth is largely broken down in the digestive tract. Injecting it delivers the molecule directly, at a fraction of the cost and time of an IV infusion, with the dose set by your physician.
What are the side effects of NAD+ injections?
Most people tolerate it well. The most common effects are mild and short-lived: redness or bruising where you inject, a warm flush, nausea, headache or fatigue. Injecting slowly and staying hydrated helps. Stop and seek care for hives, swelling or trouble breathing.
Is NAD+ safe for long-term use?
NAD+ is a molecule your body makes every day, and ongoing use is a maintenance dose, not an escalation. Your physician reviews how you feel at each check-in and decides with you whether to continue, adjust or stop.
NAD+ Injection educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
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References
- 1.NAD+ and its precursors are central to energy metabolism and DNA repair, and NAD+ levels decline with age; restoring them is an active area of longevity research. Cell Metabolism, 2018 (Yoshino J, Baur JA, Imai S)
- 2.Human tissue NAD+ declines with age alongside rising oxidative stress markers. PLoS ONE, 2012 (Massudi H et al.)
- 3.Review of the in vivo evidence for NAD-boosting molecules and their therapeutic potential in aging. Cell Metabolism, 2018 (Rajman L, Chwalek K, Sinclair DA)
- 4.Raising NAD+ in healthy middle-aged and older adults was well tolerated over six weeks in a randomized crossover trial. Nature Communications, 2018 (Martens CR et al.)
Starting price applies to the 6-month plan. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.