Epithalon
RxA pineal peptide studied for telomere maintenance and the regulation of melatonin and sleep, used in longevity protocols.
- Studied for telomerase activation and telomere length
- Supports the pineal gland's melatonin rhythm
- Short courses by subcutaneous injection, dosed by your physician
- Monthly and 3-month plans
- Starting price applies to the 3-month plan
- US-licensed pharmacies
- Pause or cancel anytime
Starting at
$189 / mo
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
What is Epithalon?
(ep-ih-THAL-on; also written Epitalon)
Epithalon is a four-amino-acid peptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a substance produced by the pineal gland. In laboratory studies it switches on telomerase, the enzyme that rebuilds the protective caps (telomeres) on chromosomes, and it supports the pineal gland's production of melatonin, which is why people often notice sleep first. It is typically used in short courses a few times a year.
Get Startedthe pineal tetrapeptide that has been shown to lengthen telomeres in human cell lines
4 aa
Human data come mostly from older Russian studies; recent work is in cell lines. Prescribed off-label at your physician's discretion.
How skin and longevity peptides work
Day 1
A US-licensed physician reviews your goals and history and sets your dose and course. The kit includes everything you need.
Week 1–2
A small subcutaneous injection, daily or on the course your physician sets. Sleep and skin hydration are often the first things people notice.
Month 1–2
Collagen signaling takes weeks to show: skin texture and firmness, and recovery after training, tend to change next.
Month 3–6
Changes consolidate with consistent use. Your physician checks in, adjusts the dose and decides on the next course.
Beyond
Longevity is a long game: sleep, movement, nutrition and sun protection do most of the work. Peptides support them.
Results you can feel
SkinSleepSkin quality
firmness, hydration and texture, over weeks
Deeper sleep
reported most with Epithalon and CJC-1295
Recovery
less soreness and faster repair after hard days
Healthy aging
a protocol you build with your physician over time
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Tested for quality, backed by science
We only work with US-licensed pharmacies that prioritize strict quality control standards, so you can count on purity, potency, and safety.
- Pure: compounded to order with pharmaceutical-grade ingredients
- Potent: lab-tested to match the labeled dose
- Sterile: prepared to USP standards by LegitScript-certified pharmacies
Your plan, reviewed
Physician-reviewedDose set by a physician, adjusted at every check-in
Your reviewing physician
Scott Nass, MD
Board-certified family physician. Every longevity peptide plan at Zepym Health is reviewed by a licensed physician before anything is prescribed, and adjusted with you as you go.
Meet the teamWhat the research says
The science of skin and longevity peptides
In 2025 work on human cell lines, Epithalon increased telomere length through telomerase upregulation or alternative lengthening; a 2025 overview summarizes its antioxidant, pineal and circadian effects.
Controlled modern human trials are lacking, and telomere length in a dish is not the same as longer life. Your physician frames Epithalon as a longevity-protocol adjunct, not a proven life extender.
Learn more
Subscribe & save
Longevity care that starts with you
Our in-house physicians meet you where you are, and get you to where you want to be.
$189/ mo
Applies to the 3-month plan billed in full ($189/mo on the monthly plan)
What's included
- Personalized, physician-guided plan
- Monthly and 3-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
Personalized for you
Made for your biology
No two people age the same way, so no two treatments are exactly the same. Your plan is guided by your symptoms, your biology, and your priorities. It's a whole “you” approach to living a better, longer life.
Get StartedHow it works
Choosing how you age starts here
- 1
Physician-led
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3100% online
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Epithalon educational content reviewed by our physician
Scott Nass, MD
Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
May the source be with you.
We read the research so you don't have to. Here's what the science says.
- 1
Topically applied GHK-Cu as an anti-wrinkle peptide: advantages, problems and prospects.
Bioimpacts, 2025 - 2
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Biogerontology, 2025 - 3
Overview of Epitalon, a highly bioactive pineal tetrapeptide with promising properties.
Int J Mol Sci, 2025 - 4
Prolonged stimulation of growth hormone and IGF-1 secretion by CJC-1295 in healthy adults.
J Clin Endocrinol Metab, 2006 - 5
Human growth hormone and human aging: the age-related decline in growth hormone output.
Endocr Rev, 1993
Starting at $189 / mo
Get Started