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Epithalon

LongevitySleep

Epithalon

RxPrescription onlyInjected under the skin · 5 days a week · 0.4 mg · Longevity · Sleep

Starting at $209/mo

A pineal peptide studied for telomere maintenance and the regulation of melatonin and sleep, used in longevity protocols.

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Start treatment· $209/mo

Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.

  • Studied for telomerase activation and telomere length
  • Supports the pineal gland's melatonin rhythm
  • Short courses by subcutaneous injection, dosed by your physician

Every plan includes

  • Personalized, physician-guided plan
  • Monthly, 3-month and 6-month plans
  • Dispensed by a US-licensed compounding pharmacy
  • Unlimited protocol adjustments and messaging
  • Ongoing support and check-ins
  • Pause or cancel anytime
  • Reviewed by our in-house physicians
  • Physician-guided care
  • Ongoing, expert support
  • 100% online
  • Free, discreet shipping

What is Epithalon?

(ep-ih-THAL-on; also written Epitalon)

Epithalon is a four-amino-acid peptide (Ala-Glu-Asp-Gly) modeled on epithalamin, a substance produced by the pineal gland. In laboratory studies it switches on telomerase, the enzyme that rebuilds the protective caps (telomeres) on chromosomes, and it supports the pineal gland's production of melatonin, which is why people often notice sleep first. It is typically used in short courses a few times a year.

How it is taken
Injected under the skin
How often
5 days a week
Dose range
0.4 mg
Form
Longevity · Sleep

4 aa

the pineal tetrapeptide that has been shown to lengthen telomeres in human cell lines

Human data come mostly from older Russian studies; recent work is in cell lines. Prescribed off-label at your physician's discretion.

How it works,
week by week.

  1. Day 1

    A US-licensed physician reviews your goals and history and sets your dose and course. The kit includes everything you need.

  2. Week 1–2

    A small subcutaneous injection, daily or on the course your physician sets. Sleep and skin hydration are often the first things people notice.

  3. Month 1–2

    Collagen signaling takes weeks to show: skin texture and firmness, and recovery after training, tend to change next.

  4. Month 3–6

    Changes consolidate with consistent use. Your physician checks in, adjusts the dose and decides on the next course.

  5. Beyond

    Longevity is a long game: sleep, movement, nutrition and sun protection do most of the work. Peptides support them.

What you may notice,
and when.

  • Skin quality

    firmness, hydration and texture, over weeks

  • Deeper sleep

    reported most with Epithalon and CJC-1295

  • Recovery

    less soreness and faster repair after hard days

  • Healthy aging

    a protocol you build with your physician over time

Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.

Safety first:
what to know before you start.

Important safety information and common side effects

Skin and longevity peptides are generally well tolerated. Common, mild effects include redness, itching or a small bump at the injection site, headache, flushing, fatigue or vivid dreams in the first days, and, with CJC-1295, water retention or tingling in the hands. GHK-Cu contains copper: tell your physician about Wilson's disease or copper sensitivity. Because these peptides support cell growth and, in Epithalon's case, telomerase, they are not prescribed with an active cancer, a cancer under evaluation, or during pregnancy or breastfeeding. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Tell your physician about every medication you take.

The research behind
epithalon.

A synthetic tetrapeptide from the Khavinson group in St. Petersburg. The evidence is mostly animal and cell work from one main group, with little independent replication.

What the studies found

  • Changed melatonin and cortisol levels in old monkeys (animal study, described in the 2025 review). This is animal work, unproven in people.
  • Lengthened telomeres in human cell lines (Biogerontology 2025). This is cell work, unproven in people.
  • Small reports in older people come from the developers' group; we could not check their primary papers, so no human benefit is claimed here.

The sources here are secondary reviews and developer-led work. The primary papers should be checked before relying on any figure. Epithalon is not FDA-approved for any use.

What this does not say

  • We found no placebo-controlled human trial with a clear outcome.
  • The melatonin and telomere claims rest largely on the developers' own work or on cell and animal studies.
  • No independent source establishes a dose for people.

The research
behind it.

In 2025 work on human cell lines, Epithalon increased telomere length through telomerase upregulation or alternative lengthening; a 2025 overview summarizes its antioxidant, pineal and circadian effects.

Controlled modern human trials are lacking, and telomere length in a dish is not the same as longer life. Your physician frames Epithalon as a longevity-protocol adjunct, not a proven life extender.

NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research

Getting started
takes a few minutes.

  1. 1

    Connect with a physician

    Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.

  2. 2

    Get your discreet shipment

    If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.

  3. 3

    Receive continuous support

    Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.

Start treatment

Frequently asked questions

Contact support
How do I use Epithalon?

Injected under the skin, 5 days a week, at bedtime. The starting prescription is 20 units (0.4 mg) each time. Your physician sets your own dose and it is printed on your label.

How much arrives in each shipment?

1 vial at the starting strength, shipped to your door from a licensed US pharmacy.

How is Epithalon taken?

Usually as a course: daily subcutaneous injections for 10 to 20 days, repeated two or three times a year, rather than continuously. Your physician sets the course length and spacing. Many people report deeper sleep within the first course.

How do I take it?

A small subcutaneous injection with an insulin-style needle, usually in the abdomen. GHK-Cu and CJC-1295 are typically daily (CJC-1295 at night); Epithalon runs in short courses. Your physician sets the schedule; the kit includes everything.

When will I see results?

Sleep changes can show within days; skin and tissue changes take weeks because collagen turns over slowly. Most people judge a protocol at three months with their physician. Individual results vary.

How strong is the evidence?

Honest answer: mixed. Topical GHK-Cu has human skin studies; CJC-1295 has controlled human pharmacology data; Epithalon rests on cell-line and older clinical work. None has large modern trials for longevity outcomes. These peptides are prescribed off-label at your physician's discretion.

Epithalon educational content reviewed by our physician

Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine

Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.

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References

  1. 1.Topically applied GHK-Cu as an anti-wrinkle peptide: advantages, problems and prospects. Bioimpacts, 2025
  2. 2.Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology, 2025
  3. 3.Overview of Epitalon, a highly bioactive pineal tetrapeptide with promising properties. Int J Mol Sci, 2025
  4. 4.Prolonged stimulation of growth hormone and IGF-1 secretion by CJC-1295 in healthy adults. J Clin Endocrinol Metab, 2006
  5. 5.Human growth hormone and human aging: the age-related decline in growth hormone output. Endocr Rev, 1993

Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.