NAD+
Supports cellular energy, focus and healthy aging by restoring the NAD+ levels that decline with age, for a fraction of the cost of IV infusions.
Injection
from $179/mo
Taken by mouth · Once a day
MitochondrialCognitionRedox
Methylene Blue Capsules
Methylene blue: a redox-active dye studied for mitochondrial function, cognitive support, and mild antidepressant effects. Crosses the blood-brain barrier. Causes blue urine; important precautions with certain medications.
- Supports mitochondrial electron transport and ATP production
- Crosses blood-brain barrier; studied for cognitive aging
- Emerging evidence for mood and energy support
- Monthly$159/mo
- Every 3 months$417 billed up front$139/mo
- Every 6 monthsBest value$774 billed up front$129/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strengths
- 2 options · 25–50 mg
What is methylene blue?
(methylene blue, a redox-active dye)
Methylene blue is a redox-active molecule that accepts and donates electrons in cellular energy pathways. It can penetrate mitochondria and the blood-brain barrier, making it unique among antioxidants. Low-dose methylene blue is studied for supporting mitochondrial function, slowing cognitive aging, and potentially improving mood. A striking side effect: urine turns bright blue or blue-green for 24-48 hours after dosing.
What's in it
- Methylene BlueCarries electrons in the mitochondria
Emerging
mitochondrial support with cognitive and mood applications
Methylene blue is not FDA-approved for any indication but is prescribed off-label. Doses range 5-20 mg daily. Do not use with SSRIs or MAOIs (serotonin syndrome risk).
Is it right for you?
Who it's for
Adults interested in mental energy who take no antidepressants.
What sets it apart
A century-old dye that carries electrons in the mitochondria. It turns urine blue-green.
Worth knowing before you start
Never with antidepressants or migraine triptans: together they can cause serotonin syndrome.
What to expect
Improved energy
especially with repeated dosing over weeks
Clearer thinking
mental fog may lift gradually
Mood support
emerging evidence in depression and anxiety
Cellular protection
antioxidant and mitochondrial support
How cellular support compounds work
Day 1
Your physician reviews your energy, cognition, mood, medications, and health history. Discusses how glutathione or methylene blue support mitochondrial and antioxidant systems.
1Week 1
Start with your prescribed dose of glutathione or methylene blue capsules. Take with food to improve tolerance. Expect blue urine if taking methylene blue.
2Weeks 2-4
Some people notice improved energy, mood, or mental clarity. Others see no immediate change. Cellular repairs take time; be patient.
3Month 2
Your physician checks in on energy, mood, cognition, and any side effects. Discuss timing, dose, or whether to continue or adjust.
4Beyond
Cellular support compounds work best on a consistent schedule. Your physician reassesses every 3-6 months based on your response and evolving research.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (25 mg)
- How often
- Once a day
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (25 mg) by mouth once daily with food for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 25 mg
- 50 mg
The science of cellular repair
Methylene blue enhances mitochondrial complex I and complex III function, supporting ATP production. In animal models and small human studies, it shows neuroprotective and antidepressant-like effects.
Human clinical trials are limited and early-stage. Some small studies suggest cognitive benefits in older adults and mood improvement in depression. Your physician monitors your response carefully.
Learn moreImportant safety information and common side effects
Glutathione and methylene blue are generally well tolerated at recommended doses. Glutathione: no established upper limit; side effects are rare. Methylene blue: at therapeutic doses (5-20 mg daily) is safe, but do not combine with SSRIs, MAOIs, or tricyclic antidepressants due to serotonin syndrome risk. Tell your physician about all medications, especially psychiatric drugs. Methylene blue may reduce the efficacy of some antibiotic or chemotherapy drugs; discuss with your physician if on cancer treatment. Methylene blue can reduce oxygen saturation slightly; avoid in people with severe anemia or respiratory disease. Stop and seek care for signs of serotonin syndrome (rapid heart rate, confusion, muscle rigidity, hyperthermia) if using methylene blue with psychiatric medications.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Methylene blue educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Methylene Blue Capsules?
Taken by mouth, once a day. The starting prescription is 1 capsule (25 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Methylene Blue Capsules come in?
The pharmacy carries 2: 25 mg, 50 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why does methylene blue turn my urine blue?
Methylene blue is a dye; your kidneys filter it, coloring urine blue or blue-green for 24-48 hours after a dose. This is harmless and expected. You may also notice blue staining of the mouth or tongue.
When will I feel better?
Energy and mood changes can take 2-4 weeks with consistent dosing. Cognitive benefits may take months to notice. Some people respond quickly; others need sustained use. Keep a symptom log.
Can I combine glutathione and methylene blue?
These are separate compounds with different mechanisms. Some physicians use both; others prefer one. Discuss your health goals and medication history with your physician to decide the best approach.
Are there interactions with my other medications?
Methylene blue has significant interactions with psychiatric medications (SSRIs, MAOIs, tricyclics) due to serotonin syndrome risk. Tell your physician about every medication you take.
Is this supported by clinical evidence?
Glutathione and methylene blue show promise in early-stage and animal studies. Human clinical trials are limited. Your physician uses these based on mechanistic reasoning and emerging evidence, not established clinical practice.
Cellular health and protection.
Glutathione Injection
A master antioxidant that supports your body's natural detox pathways, skin clarity and recovery. Prescribed and dosed by a licensed clinician.
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Epithalon
A peptide studied for cellular aging and sleep regulation, used in longevity protocols. Prescribed and dosed by a licensed physician.
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Glutathione Capsules
Oral Glutathione for antioxidant support, cellular health, and longevity. A master antioxidant that supports detoxification and cellular function.
Capsule
from $89/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Glutathione: a master antioxidant and cellular regulator.
J Nutr Biochem, 2007 - 2
Methylene blue as a mitochondrial and neuroprotective agent.
Redox Biol, 2017
Methylene Blue Capsulesfrom $129/mo