NAD+
Supports cellular energy, focus and healthy aging by restoring the NAD+ levels that decline with age, for a fraction of the cost of IV infusions.
Injection
from $179/mo
Injected under the skin · 5 days a week
Research peptideEnergyMitochondria
SS-31 (Elamipretide)
SS-31 (elamipretida): a mitochondrial peptide studied for cellular energy, muscle fatigue, and recovery. Targets cardiolipin in the inner mitochondrial membrane. Subcutaneous injection. Very early-stage human evidence; most data from mito disorders.
- Studied for cellular energy and mitochondrial function
- Preclinical evidence in muscle and cardiac fatigue
- Emerging clinical interest for energy-related conditions
- Monthly$299/mo
- Every 3 months$717 billed up front$239/mo
- Every 6 monthsBest value$1,254 billed up front$209/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Injected under the skin
- How often
- 5 days a week
- Each shipment
- 1 vial
- Strengths
- 2 options · 0.4–0.8 mg
What is SS-31?
(elamipretida; mitochondrial-targeted peptide)
SS-31 (elamipretida) is a short peptide that crosses the mitochondrial membranes and binds to cardiolipin, a lipid critical for ATP (cellular energy) production. By supporting mitochondrial electron transport, SS-31 enhances energy generation within cells. It is being studied in mitochondrial myopathies and cardiomyopathy. Off-label use for generalized fatigue or recovery is emerging, though human evidence is limited.
What's in it
- SS-31Targets the mitochondria
Early
human evidence; strong preclinical mitochondrial support
SS-31 is prescribed off-label for fatigue and energy based on preclinical mechanistic support and small clinical experience. It is not approved by the FDA for any indication.
Is it right for you?
Who it's for
Adults interested in the newest mitochondrial peptide.
What sets it apart
The only peptide here that has been through clinical trials for mitochondrial disease, at much higher doses than this.
Worth knowing before you start
Redness and a firm bump at the injection site were the most common effect in trials. Rotate sites.
Results you may experience
Improved energy
more consistent stamina for daily tasks and exercise
Better recovery
muscles bounce back faster from workouts
Sustained endurance
longer work or training sessions feel less exhausting
Patience required
mitochondrial function takes weeks to shift; tracking helps
How SS-31 works
Day 1
A US-licensed physician reviews your fatigue, exercise capacity, medical history, and cardiac history. Discusses how SS-31 supports mitochondrial function and the evidence gap.
1Week 1
Start with subcutaneous injections, typically 3–5 days per week. Most people find the routine comfortable within days.
2Weeks 2–4
Energy, exercise tolerance, and recovery may begin to improve. Some notice changes within days; others take 3–4 weeks. Keep an energy and exercise log.
3Month 2
Your physician checks in, reviews your energy log, and adjusts dose if needed. Discuss any changes in fatigue, muscle function, or exercise capacity.
4Beyond
SS-31 works best with consistent dosing and exercise. Your physician monitors your response every 4–6 weeks and adjusts as your needs change.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Injected under the skin
- Dose
- 20 units (0.4 mg)
- How often
- 5 days a week
- When
- In the morning
- Each shipment
- 1 vial
- Pharmacy label
- Inject 20 units (0.4 mg) subcutaneously in the morning 5 days per week for 4 weeks. Discard any remaining medication.
A sample week
- M
- T
- W
- T
- F
- S
- S
5 days a week
Strengths the pharmacy carries
- 4 mg/mL
- 2 mg/mL
The science of mitochondrial peptides
SS-31 improves mitochondrial function and ATP synthesis in cell and animal models of energy depletion, cardiac stress, and muscle damage.
Human clinical trials are few and limited to mitochondrial disease. Off-label use for general fatigue or recovery is based on mechanism and anecdote, not rigorous trials. Your physician explains this gap and monitors energy and muscle function at check-ins.
Learn moreImportant safety information and common side effects
SS-31 is prescribed off-label based on preclinical support and early clinical experience. It is generally well tolerated; common mild effects are injection-site reactions, headache, or temporary energy fluctuations in the first week as mitochondrial function shifts. SS-31 is not prescribed during pregnancy or breastfeeding, or with severe cardiac arrhythmias without careful discussion—it works on mitochondria in all tissues, including heart. Tell your physician about every medication, supplement, and any history of heart disease or arrhythmias. Stop and seek care for severe headache, chest pain, palpitations, or signs of allergic reaction.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
SS-31 educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use SS-31?
Injected under the skin, 5 days a week, in the morning. The starting prescription is 20 units (0.4 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does SS-31 come in?
The pharmacy carries 2: 2 mg/mL, 4 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Who might benefit from SS-31?
People with chronic fatigue, muscle weakness, or poor recovery from exercise, whose fatigue appears linked to mitochondrial or energy metabolism issues. Your physician reviews your history and may order bloodwork to assess cellular energy markers before starting.
How long until I feel more energy?
Some people notice improved energy within 1–2 weeks; others take 4–6 weeks. Consistent dosing (3–5 injections per week) is essential. Keep an energy log tracking tiredness, exercise capacity, and recovery. Small, subtle improvements often precede major shifts.
Can I use SS-31 with other medications?
Tell your physician about all medications, especially cardiac or arrhythmia drugs. SS-31 works at the mitochondrial level, so heart medications need careful review. Most combinations are compatible, but timing or dose adjustments may be needed.
What if I don't notice a change?
Mitochondrial function can take 6–8 weeks to measurably shift. Keep detailed logs of energy, exercise capacity, and recovery. If no improvement after 8–10 weeks, your physician may adjust the dose or explore whether SS-31 is the right fit for you.
How does SS-31 affect exercise?
SS-31 supports mitochondrial ATP production, which should improve endurance and recovery. You may notice you can work harder before fatigue sets in, or that muscle soreness after exercise eases sooner. Pair SS-31 with consistent exercise for best results.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
SS-31 (elamipretida): a mitochondrial-targeting peptide for cardiac and mitochondrial disease.
Circulation, 2016 - 2
Cardiolipin and the inner mitochondrial membrane: mechanisms of cardiolipin-induced cellular stress.
Biochim Biophys Acta, 2014
SS-31 (Elamipretide)from $209/mo