Injection
Tesamorelin
A peptide that targets stubborn abdominal fat and supports a leaner body composition, prescribed and monitored by a licensed clinician.
Starting at $179/mo
Energy & recoveryLean muscle
Sermorelin Injection
RxPrescription onlyInjected under the skin · 5 days a week · 0.3–0.6 mg · Energy & recovery · Lean muscle
Starting at $179/mo
Supports energy, lean muscle mass, and strength by encouraging the body to replenish its own growth hormone gradually, without the risks of synthetic HGH.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Members commonly report deeper, more restorative sleep
- Supports lean muscle, strength and recovery
- Works with your body's own rhythm instead of overriding it
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is Sermorelin?
(ser-mor-luhn)
After age 30, growth hormone levels decline steadily each decade, affecting everything from metabolism and muscle tone to recovery and sleep quality. Unlike synthetic HGH, which overrides the system, sermorelin works with the body: it signals the brain to release its own growth hormone in a natural, pulsed rhythm, to support lean muscle, energy and metabolism.
- How it is taken
- Injected under the skin
- How often
- 5 days a week
- Dose range
- 0.3–0.6 mg
- Form
- Energy & recovery · Lean muscle
How it works,
week by week.
2 Weeks
Sermorelin begins supporting the brain's growth hormone regulation, nudging your own pulses back up.
2 Months
Deeper, more restorative sleep is usually the first change people notice, with steadier energy through the day.
3 Months
Recovery after training and early gains in strength and lean mass tend to show. Your physician reviews your plan.
6 Months
Body composition changes consolidate with consistent use, training and sleep.
1 Year and Beyond
A maintenance plan keeps your own growth hormone rhythm supported. Your physician decides with you how to continue.
What you may notice,
and when.
Better sleep
the most common change members report in their first weeks
Lean muscle
with training, strength and recovery improve first
More energy
steadier through the day
Better mood
many members report feeling more like themselves
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Sermorelin is generally well tolerated. Common, mild effects include redness, swelling or itching at the injection site, headache, flushing, dizziness or sleepiness that pass in hours. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Sermorelin is not for people with an active cancer, and your physician needs to know about diabetes, thyroid disease, pregnancy or breastfeeding, and every medication you take, including steroids and thyroid hormone.
The research behind
sermorelin.
A GHRH analogue made of the first 29 amino acids of the natural hormone. FDA approved it in 1997 for children with growth failure from idiopathic growth hormone deficiency; the maker discontinued it in 2008. Adult evidence is limited to small trials of hormone levels.
- FDA historyapproved 1997, discontinued 2008
FDA approved GEREF (sermorelin acetate) vials on September 26, 1997, for treating idiopathic growth hormone deficiency in children with growth failure. The maker, EMD Serono, discontinued it in 2008. In 2013 FDA determined it was not withdrawn for reasons of safety or effectiveness.
FDA, Federal Register determination on GEREF (sermorelin acetate), 2013 - Adult useeditorial, no trial data
Walker's 2006 paper is an editorial proposing sermorelin as an alternative to recombinant growth hormone in aging. It presents no trial data of its own, and says the society would supply sermorelin to practitioners to study under protocol.
Walker, Clin Interv Aging 2006 - Adult trials10 to 19 older adults
Corpas (1992, 10 older men), Vittone (1997, 11 men) and Khorram (1997, 19 men and women, using a close analogue) measured growth hormone and IGF-I over 2 to 16 weeks of treatment. None measured a clinical outcome.
Corpas et al., J Clin Endocrinol Metab 1992; Vittone et al., Metabolism 1997; Khorram et al., J Clin Endocrinol Metab 1997
What the studies found
- Raised overnight growth hormone release in healthy men aged 64 to 76 after 6 weeks of nightly injections (Vittone, Metabolism 1997; 11 men)
- Raised IGF-I in older men at the higher dose, given twice daily for 14 days (Corpas, J Clin Endocrinol Metab 1992; 10 men)
- Improved 2 of 6 strength tests and abdominal endurance in older men (Vittone, Metabolism 1997; 11 men)
- In men, increased insulin sensitivity and improved self-rated well-being and libido after 16 weeks of a close analogue (Khorram, J Clin Endocrinol Metab 1997; 9 men)
- Increased height velocity in children with idiopathic growth hormone deficiency, the one use FDA approved (1999 review of pediatric trials; FDA 2013 notice)
No approved sermorelin product is marketed: the FDA-approved GEREF is on the discontinued list. Sermorelin used today is compounded, and adult use is off-label. The injection and the sublingual troche are different products. No human trial of the troche was found.
What this does not say
- The adult trials lasted 2 to 16 weeks, and no long-term outcome trial in adults was found.
- Growth hormone-releasing drugs raise IGF-I, and the effects of sustained elevation are not established.
- Compounded product quality and dose accuracy are not verified. No human study of the sublingual troche was found.
The research
behind it.
Sermorelin is an analog of growth hormone-releasing hormone (GHRH). Unlike direct HGH therapy, sermorelin signals the pituitary gland to release human growth hormone in a pulsed, physiological rhythm, supporting a more balanced approach to hormone therapy.
Research suggests sermorelin may help restore the body's own growth hormone output as it declines with age, supporting the ability to build muscle, restore energy, sleep better and improve overall quality of life.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Sermorelin Injection?
Injected under the skin, 5 days a week, at bedtime. The starting prescription is 10 units (0.3 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Sermorelin Injection come in?
The pharmacy carries 2: 15 mg (3 mg/mL), 15 mg (3 mg/mL). Your physician chooses which one you get.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How is Sermorelin different from HGH?
HGH replaces the hormone directly and can suppress your own production. Sermorelin does the opposite: it signals your pituitary to release its own growth hormone in natural pulses, so levels rise gradually and stay within a physiological range.
How is it taken?
A small subcutaneous injection, usually at night before bed, when your body naturally releases growth hormone. Your physician sets the dose and frequency; your kit includes everything.
What are the side effects?
Most people tolerate it well. The most common effects are mild and short-lived: redness or itching where you inject, headache, flushing or sleepiness. Stop and seek care for hives, swelling or trouble breathing.
Is Sermorelin safe for long-term use?
Because sermorelin supports your own production rather than replacing the hormone, it is used as a maintenance plan. Your physician reviews how you feel and, when appropriate, lab work at each check-in and decides with you whether to continue, adjust or pause.
Sermorelin educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Troche
Sermorelin Troches
The same growth hormone-releasing peptide as a dissolving troche, for people who would rather skip injections.
30 troches per month
Starting at $209/mo
Injection
CJC-1295 / Ipamorelin
Two peptides that prompt your pituitary to release your own growth hormone, used for deeper sleep, recovery and body composition. Prescribed and dosed by a licensed physician.
Starting at $229/mo
Injection
BPC-157
A peptide studied for tissue repair and recovery, used to support healing of muscle, tendon and gut after injury or hard training. Prescribed and dosed by a licensed physician.
Starting at $209/mo
References
- 1.Review of sermorelin as a GHRH analog for adult-onset growth hormone insufficiency: stimulates the body's own growth hormone in a physiological pattern. Clinical Interventions in Aging, 2006 (Walker RF)
- 2.Growth hormone secretion declines progressively with age in adults, with effects on body composition, muscle and sleep. Endocrine Reviews, 1993 (Corpas E, Harman SM, Blackman MR)
- 3.Growth hormone-releasing hormone improved cognition in healthy older adults in a randomized trial. Neurobiology of Aging, 2006 (Vitiello MV et al.)
- 4.Sermorelin's mechanism, safety profile and clinical use as a growth hormone secretagogue. BioDrugs, 1999 (Prakash A, Goa KL)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality.