Tablet
Ezetimibe Tablets
Ezetimibe, a cholesterol-absorption inhibitor, used to lower cholesterol levels. Commercial formulation prescribed and dosed by a licensed physician.
30 tablets per month
Starting at $69/mo
Everyday prevention,
checked against the big trials.
Vitamin D, omega-3, coenzyme Q10 and ezetimibe are everyday choices. We recommend them when your labs and history give a reason, and we say what the trials did not show.
A supplement is not a plan
until you know what it is for.
Vitamin D and omega-3 are often taken to prevent cancer and heart disease. In VITAL, a trial of 25,871 healthy adults, neither one lowered the main cancer or cardiovascular results in the general population.¹ Benefit has shown up in narrower groups, such as people on statins with high triglycerides.²
Our in-house care team of U.S.-licensed physicians and nurse practitioners starts with your history and your labs, recommends only what they support, and rechecks you over time.
- 1.Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease (VITAL), Manson JE et al., N Engl J Med, 2019.
- 2.Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT), Bhatt DL et al., N Engl J Med, 2019.
What the big trials found
and what they did not.
- Fewer heart attacks28%
lower hazard of total heart attack with 1 g a day of omega-3 (EPA and DHA), hazard ratio 0.72 (95% CI 0.59 to 0.90), in 25,871 adults followed for a median of 5.3 years. Heart attack was a secondary endpoint: the main composite of heart attack, stroke and cardiovascular death was not lower (hazard ratio 0.92).
VITAL omega-3 trial, N Engl J Med, 2019 - Invasive cancer, with vitamin D30.96
hazard ratio for invasive cancer with 2,000 IU a day of vitamin D3 versus placebo (95% CI 0.88 to 1.06), in the same 25,871 adults. Major cardiovascular events were not lower either (hazard ratio 0.97).
VITAL vitamin D trial, N Engl J Med, 2019 - Lower LDL, with ezetimibe added to a statin23%
lower average LDL with ezetimibe added to simvastatin (53.7 vs 69.5 mg/dL) in 18,144 patients after a recent acute coronary syndrome. The 7-year event rate fell from 34.7% to 32.7%.
IMPROVE-IT, N Engl J Med, 2015
In IMPROVE-IT, adding ezetimibe to simvastatin lowered the 7-year rate of the primary cardiovascular endpoint by 2 percentage points (32.7% vs 34.7%), in patients hospitalized for an acute coronary syndrome. Cannon CP et al., N Engl J Med, 2015
These are trial averages in specific groups, not predictions for you. The vitamin D and omega-3 trials tested doses that differ from ours, and the heart attack result was a secondary endpoint. The 23% LDL figure is our calculation from the trial's average values, not a number the trial reported.
Start with the test,
then choose the product.
A vitamin D blood level tells you whether you are low. A lipid panel tells you whether your LDL cholesterol needs treatment. Our fully in-house care team orders the right labs, recommends what the results support, and rechecks the numbers that matter for you.
We test first, recommend what the results support, and recheck the levels that matter for you, so you know what changed and why, with plans starting at $53 a month.
Start hereWe read the trials on everyday supplements
before we recommend them.
Supplements for prevention are sold on promises that large trials often did not confirm. We read the outcome trials, state their limits, and recommend only what your labs and history justify.
Vitamin D and omega-3:
what the big trials foundVITAL and STRENGTH: what happened to cancer, heart attacks and cardiovascular events, and how the prescription EPA trial differs.Read the researchLowering LDL cholesterol:
where ezetimibe fitsIMPROVE-IT, coenzyme Q10 in heart failure and statin muscle symptoms: what each trial tested and where the evidence stops.Read the research
what the big trials foundVITAL and STRENGTH: what happened to cancer, heart attacks and cardiovascular events, and how the prescription EPA trial differs.Read the researchLowering LDL cholesterol:
where ezetimibe fitsIMPROVE-IT, coenzyme Q10 in heart failure and statin muscle symptoms: what each trial tested and where the evidence stops.Read the research
Every wellness treatment,
in one place.
Tablets
1Taken by mouth with water.
Capsules
4Taken by mouth with water.
Capsule
Vitamin D3 / K2 Capsules
Vitamin D3 and K2 combination for bone health, cardiovascular support, and immune function. Recommended by physicians for wellness optimization.
9 capsules per month
Starting at $53/mo
Capsule
Vitamin D3 Capsules
Vitamin D3, essential for bone health, immune function, and overall wellness. Prescribed and dosed by a licensed physician.
30 capsules per month
Starting at $63/mo
Capsule
Fish Oil Capsules
Fish Oil supplements rich in omega-3 fatty acids for cardiovascular health, inflammation support, and overall wellness.
30 capsules per month
Starting at $79/mo
Capsule
CoQ10 Capsules
Coenzyme Q10 for cellular energy production, antioxidant support, and cardiovascular health. Often recommended for those on statin therapy.
30 capsules per month
Starting at $109/mo
5 treatments in this area, all from our live catalog.
Questions,
answered.
Contact supportDoes vitamin D prevent cancer or heart disease?
The largest trial, VITAL, did not find that 2,000 IU a day of vitamin D3 lowered invasive cancer or major cardiovascular events in healthy adults. Vitamin D deficiency is still treated when a blood test shows it.
Should I take fish oil for my heart?
In VITAL, 1 g a day of omega-3 did not lower the main cardiovascular endpoint. In REDUCE-IT, 4 g a day of prescription EPA did, in people with high triglycerides on a statin. Our fish oil capsules are not that product, so we will explain which applies to you.
Do I need a vitamin D test before I take it?
Not for everyone. The Endocrine Society recommends a blood test for people at risk of deficiency, and it does not recommend routine screening of people who are not at risk.
What does ezetimibe do?
Ezetimibe reduces the cholesterol absorbed from the intestine and lowers LDL. In IMPROVE-IT, adding it to a statin after a recent acute coronary syndrome lowered the 7-year rate of the main cardiovascular endpoint by 2 percentage points.
Does coenzyme Q10 help statin muscle pain?
The evidence is mixed. A 2018 meta-analysis found benefit, and a 2020 systematic review found none. The trials are small, so we review your symptoms and your history before adding it.
References
- 1.Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease (VITAL). N Engl J Med, 2019 (Manson JE et al.)
- 2.Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer (VITAL). N Engl J Med, 2019 (Manson JE et al.)
- 3.Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia (REDUCE-IT). N Engl J Med, 2019 (Bhatt DL et al.)
- 4.Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes (IMPROVE-IT). N Engl J Med, 2015 (Cannon CP et al.)
- 5.Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011 (Holick MF et al.)
Dietary supplements are not reviewed by the FDA for safety and effectiveness before they are sold. Prescription products, including ezetimibe, require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.