Injection
Sermorelin Injection
A growth hormone-releasing peptide that supports deeper sleep, faster recovery and lean muscle by working with your body's own rhythm.
Starting at $179/mo
Body compositionAbdominal fat
Tesamorelin
RxPrescription onlyInjected under the skin · 5 days a week · 0.6 mg · Body composition · Abdominal fat
Starting at $179/mo
A growth hormone-releasing peptide that targets stubborn abdominal fat and supports a leaner body composition by encouraging your own growth hormone, without synthetic HGH.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Studied for reducing visceral abdominal fat, the deep fat around the organs
- Supports lean mass and recovery alongside training
- Works with your body's own growth hormone rhythm
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is Tesamorelin?
(tes-a-MOR-e-lin)
Tesamorelin is a synthetic version of growth hormone-releasing hormone (GHRH). It signals the pituitary gland to release your own growth hormone in its natural pulses. Growth hormone output falls with age, and with it the body's ability to burn deep abdominal fat and hold lean mass. Tesamorelin is the GHRH analog most studied for reducing visceral fat.
- How it is taken
- Injected under the skin
- How often
- 5 days a week
- Dose range
- 0.6 mg
- Form
- Body composition · Abdominal fat
How it works,
week by week.
2 Weeks
Tesamorelin begins restoring your own growth hormone pulses, usually with a nightly injection.
2 Months
Many people notice steadier energy and better sleep first; body changes take longer.
3 Months
Waist and abdominal fat changes tend to start showing with consistent use and training. Your physician reviews your plan.
6 Months
Body composition changes consolidate: less visceral fat, better recovery, more lean mass with training.
1 Year and Beyond
Your physician decides with you how to continue; results depend on staying on the plan, food and movement.
What you may notice,
and when.
Less abdominal fat
the change tesamorelin is best known and studied for
Lean mass
with training, strength and recovery improve
More energy
steadier through the day
Better sleep
many members report deeper sleep in the first weeks
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Important safety information and common side effects
Tesamorelin is generally well tolerated. Common, mild effects include redness, itching or swelling at the injection site, joint or muscle aches, tingling in the hands, mild fluid retention and headache, usually in the first weeks. It can raise blood sugar, so your physician may check glucose, especially if you have diabetes or prediabetes. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Not for people with an active cancer, a pituitary disorder, during pregnancy or breastfeeding. Tell your physician about every medication you take, including steroids and thyroid hormone.
The research behind
tesamorelin.
A GHRH analogue with a current FDA label for excess abdominal fat in adults with HIV-associated lipodystrophy. It has randomized trials in people, the largest in 412 adults with HIV, but only for that narrow use.
- HIV belly fatabout 15% less visceral fat
In 412 adults with HIV and excess abdominal fat, 2 mg injected daily for 26 weeks reduced visceral fat by about 15%. Most participants (86%) were men.
Falutz et al., N Engl J Med 2007 - FDA labelone approved use
The US label (EGRIFTA WR and SV, revised March 2025) is for reducing excess abdominal fat in HIV-infected adults with lipodystrophy. It says long-term cardiovascular safety has not been established and that the drug is not indicated for weight loss.
EGRIFTA WR and SV prescribing information, FDA - Cognitionsmall older-adult trial
Baker et al. (Arch Neurol 2012) gave tesamorelin 1 mg at bedtime for 20 weeks to 152 adults aged 55 to 87, 66 of them with mild cognitive impairment. Cognition improved more than on placebo across the group, most clearly for executive function.
Baker et al., Arch Neurol 2012
What the studies found
- Reduces visceral (deep abdominal) fat by about 15% over 26 weeks in adults with HIV and excess belly fat (Falutz, NEJM 2007)
- Lowers triglycerides by about 50 mg/dL over 26 weeks, while placebo raised them by about 9 mg/dL, in the same HIV trial (Falutz, NEJM 2007)
- Approved by the FDA to reduce excess abdominal fat in adults with HIV-associated lipodystrophy (EGRIFTA label, revised 2025)
- Better executive-function scores than placebo after 20 weeks in 152 older adults, 66 with mild cognitive impairment (Baker, Arch Neurol 2012)
- Reduces percent body fat by 7.4% in the same older-adult trial (Baker, Arch Neurol 2012)
The HIV trials used the 2 mg daily dose of the 1 mg-per-vial formulation, which the label describes as EGRIFTA WR. The benefit is for fat in one area, not for general weight or health. Compounded or research-grade tesamorelin was not the product studied.
What this does not say
- Approved use is limited to HIV-associated abdominal fat; it is not approved for weight loss or longevity.
- The label warns of an increased risk of neoplasms (cancer) and says long-term cardiovascular safety has not been established.
- IGF-1 rises during treatment, and the label says the effects of prolonged elevation are unknown.
- The ipamorelin partner in the blend has only the evidence on its own page; the combination was not tested together.
The research
behind it.
Tesamorelin is a GHRH analog. Rather than replacing growth hormone, it prompts the pituitary to release your own in a physiological rhythm. In randomized trials it reduced visceral abdominal fat, the metabolically active fat around the organs, while preserving lean mass.
Research also links GHRH analogs to improvements in liver fat and, in older adults, cognition. Tesamorelin's FDA-approved use is for excess abdominal fat in people with HIV; other uses are prescribed at your physician's discretion, and compounded tesamorelin is not the brand-name product.
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Tesamorelin?
Injected under the skin, 5 days a week, at bedtime. The starting prescription is 30 units (0.6 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Tesamorelin come in?
The pharmacy carries 2: 2 mg/mL, 3 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How is Tesamorelin different from Sermorelin?
Both are GHRH analogs that make your pituitary release your own growth hormone. Tesamorelin is longer-acting and is the one studied specifically for reducing visceral abdominal fat; sermorelin is more often used for sleep, recovery and general growth hormone support.
How is it taken?
A small subcutaneous injection, usually once a day at night, when your body naturally releases growth hormone. Your physician sets the dose and schedule; your kit includes everything.
What are the side effects?
Most people tolerate it well. The most common effects are mild: redness or itching where you inject, joint aches, tingling in the hands, mild fluid retention or headache. It can raise blood sugar, which your physician monitors. Stop and seek care for hives, swelling or trouble breathing.
Is Tesamorelin safe for long-term use?
Because tesamorelin supports your own production rather than replacing the hormone, it is used as an ongoing plan with regular check-ins. Your physician reviews how you feel and, when appropriate, lab work, and decides with you whether to continue, adjust or pause. Results tend to reverse if treatment stops.
Tesamorelin educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Troche
Sermorelin Troches
The same growth hormone-releasing peptide as a dissolving troche, for people who would rather skip injections.
30 troches per month
Starting at $209/mo
Injection
CJC-1295 / Ipamorelin
Two peptides that prompt your pituitary to release your own growth hormone, used for deeper sleep, recovery and body composition. Prescribed and dosed by a licensed physician.
Starting at $229/mo
Injection
BPC-157
A peptide studied for tissue repair and recovery, used to support healing of muscle, tendon and gut after injury or hard training. Prescribed and dosed by a licensed physician.
Starting at $209/mo
References
- 1.Tesamorelin reduced visceral abdominal fat and improved lipids over 26 weeks in a randomized, placebo-controlled trial. New England Journal of Medicine, 2007 (Falutz J et al.)
- 2.Pooled analysis of two phase 3 trials: sustained reduction in visceral fat with tesamorelin, with a well-characterized safety profile. Journal of Clinical Endocrinology & Metabolism, 2010 (Falutz J et al.)
- 3.Tesamorelin reduced liver fat in a randomized, double-blind trial. The Lancet HIV, 2019 (Stanley TL et al.)
- 4.Growth hormone-releasing hormone improved cognitive function in healthy older adults and adults with mild cognitive impairment. Archives of Neurology, 2012 (Baker LD et al.)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded tesamorelin is not the FDA-approved brand-name product.