Injection
Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Starting at $198/mo
Weight lossGLP-1
Semaglutide + B12
RxPrescription onlyInjected under the skin · Once a week · 0.25–2.5 mg · Weight loss · GLP-1
Starting at $99/mo
A physician-guided semaglutide plan designed to support appetite regulation, metabolic health, and long-term care beyond the scale, with vitamin B12 for energy.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Supports the gut-brain signals that help regulate fullness
- Once-weekly GLP-1 injection, dosed and adjusted by your physician
- Paired with vitamin B12 to support energy while you lose weight
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Same price at every dose, no dose upcharges
- Dispensed by a US-licensed compounding pharmacy
- Unlimited dose adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What is Semaglutide?
(sem-a-GLOO-tide, a GLP-1 receptor agonist)
Your body makes GLP-1 after you eat. It is one of the signals that tells the brain “we've had enough,” while slowing digestion and steadying blood sugar after meals. Semaglutide mimics that hormone, keeping the fullness signal active longer to support appetite regulation, steadier eating and metabolic health.
- How it is taken
- Injected under the skin
- How often
- Once a week
- Dose range
- 0.25–2.5 mg
- Form
- Weight loss · GLP-1
~15%
Average body weight reduction in the pivotal clinical trial of brand-name semaglutide
In the pivotal STEP 1 trial, adults with obesity lost on average about 15% of body weight over 68 weeks with once-weekly brand-name semaglutide plus lifestyle changes. Compounded semaglutide is not the brand-name product and was not studied in that trial; individual results vary.
How it works,
week by week.
Day 1
A US-licensed physician reviews your health profile, goals and treatment history and sets your starting dose.
7 Days
Your first weekly injection. Appetite usually quiets within days; some nausea in the first weeks is common and fades as the dose settles.
30 Days
Fullness comes sooner and cravings soften. Your physician checks how you feel before any dose increase.
6 Months
Weight loss builds steadily with the plan, food and movement. Doses are adjusted at your check-ins.
1 Year and Beyond
Maintenance is part of the plan: your physician decides with you how to hold your results or taper.
What you may notice,
and when.
Weight loss
steady and sustained, with your physician adjusting the dose
Appetite regulation
the most common change members report in their first weeks
Metabolic health
steadier blood sugar after meals
Energy
vitamin B12 helps offset the fatigue that can come with eating less
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Is semaglutide right for you?
GLP-1 medications are prescribed based on your BMI, your health history and your goals. Find your BMI on the chart to see whether you're within the usual range for treatment, then let your physician decide.
| BMI | Is semaglutide right for me? |
|---|---|
| 24.9 or less | No |
| 25.0 to 29.9 | Case-by-case (with a weight-related condition) |
| 30.0 or above | Likely |
This chart is not a medical diagnosis. Your physician approves or declines a prescription at their discretion after reviewing your unique health profile; approval is not guaranteed by these criteria.
Important safety information and common side effects
Semaglutide can cause nausea, vomiting, diarrhea, constipation, stomach pain, reduced appetite, fatigue and injection-site reactions, most often in the first weeks and when the dose goes up. Stop and seek care for severe stomach pain (possible pancreatitis or gallbladder problems), signs of an allergic reaction, or vision changes if you have diabetes. GLP-1 medications carry a boxed warning about thyroid C-cell tumors seen in rodents: do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for use in pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about diabetes medication, insulin and every medication you take.
The research behind
semaglutide.
Semaglutide is a GLP-1 receptor agonist. Its evidence comes from large randomized trials in adults with obesity, nearly all with the injected 2.4 mg weekly dose.
About the added ingredient: Vitamin B12 is added to many compounded blends. No trial has tested it for weight loss with semaglutide; it matters mainly when intake is low.
- Weightabout 15%
STEP 1: 1,961 adults with obesity or overweight and no diabetes, 68 weeks of weekly injections plus lifestyle advice. Mean weight change was -14.9% with semaglutide and -2.4% with placebo.
STEP 1, NEJM 2021 - Two yearsabout 15%
STEP 5: 304 adults, 104 weeks of weekly 2.4 mg injections with behavioral support. Mean change was -15.2% with semaglutide and -2.6% with placebo.
STEP 5, Nature Medicine 2022 - Heart events20% fewer events
SELECT: 17,604 adults aged 45 and older with overweight or obesity and existing heart disease but no diabetes, followed about 40 months. Major cardiovascular events were 6.5% on 2.4 mg weekly and 8.0% on placebo (hazard ratio 0.80).
SELECT, NEJM 2023
What the studies found
- Lowers body weight by about 15% on average over 68 weeks, against 2.4% on placebo (STEP 1, NEJM 2021).
- Keeps the loss over 104 weeks: -15.2% on semaglutide against -2.6% on placebo (STEP 5, Nature Medicine 2022).
- Lost more weight than liraglutide 3.0 mg daily: -15.8% against -6.4% at 68 weeks (STEP 8, JAMA 2022).
- Lowers major heart events by 20% in adults with overweight and heart disease but no diabetes (SELECT, NEJM 2023).
- Lowers the risk of kidney failure or death from kidney or heart causes by 24% in type 2 diabetes with chronic kidney disease (FLOW, NEJM 2024).
Trial results are for the injected 2.4 mg weekly product at the dose studied. They are averages, not predictions for one person. Compounded versions were not studied in these trials, and no trial has tested the sublingual (dissolve-under-the-tongue) form. The oral trial OASIS 4 (NEJM 2025, doi 10.1056/NEJMoa2500969) tested a 25 mg tablet swallowed, not a sublingual one.
What this does not say
- The trials ran 68 to 104 weeks. They do not show what happens over the long term after treatment is stopped.
- Nausea, diarrhea and vomiting were the most common side effects. In SELECT, 16.6% of people on semaglutide stopped the trial drug for adverse events, against 8.2% on placebo.
- SELECT and STEP trials were funded by the manufacturer; the figures are for brand-name semaglutide in trial conditions.
The research
behind it.
GLP-1 is a hormone the body already makes after eating, telling the brain “we've had enough” while slowing digestion and steadying blood sugar. Semaglutide amplifies that same signal for a full week per dose.
In the pivotal STEP 1 trial, adults with obesity lost on average about 15% of body weight over 68 weeks with once-weekly brand-name semaglutide plus lifestyle changes. In people with obesity but without diabetes, brand-name semaglutide also reduced major cardiovascular events in the SELECT trial. Compounded versions are prescribed by your physician when appropriate and are not the brand-name products.
GLP-1 beyond the scale:
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportHow do I use Semaglutide + B12?
Injected under the skin, once a week. The starting prescription is 25 units (0.25 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Semaglutide + B12 come in?
The pharmacy carries 5: 1 mg (1 mg / 0.5 mg/mL), 2 mg (2 mg / 0.5 mg/mL), 4 mg (4 mg / 0.5 mg/mL), 6 mg (6 mg / 0.5 mg/mL), 10 mg (10 mg / 0.5 mg/mL). Your physician chooses which one you get.
What exactly is in it?
Semaglutide, B12.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How does semaglutide help with weight loss?
It mimics GLP-1, a hormone that tells your brain you're full, slows how fast your stomach empties and steadies blood sugar after meals. You feel satisfied with less food, so eating less becomes sustainable rather than a fight.
What does the B12 add?
Vitamin B12 supports energy and red blood cell production. Eating less can leave some people tired; pairing B12 with the injection helps offset that.
What are the side effects?
Nausea, constipation, diarrhea and fatigue are the most common, usually in the first weeks and after a dose increase, and they fade as your body adjusts. Serious but rare risks include pancreatitis and gallbladder problems; read the safety information above and tell your physician about any history of pancreatitis or thyroid cancer.
What happens when I reach my goal?
Your physician decides with you: some people hold a maintenance dose, others taper down gradually. Either way, the plan includes the habits, food and movement that keep the weight off.
Semaglutide + B12 educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Injection
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Starting at $198/mo
Injection
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Starting at $99/mo
Tablet
Metformin
Metformin commercial tablet for weight loss support and glucose metabolism. Take daily, 30-day supply.
30 tablets per month
Starting at $79/mo
References
- 1.Once-weekly semaglutide 2.4 mg produced a mean weight loss of about 15% over 68 weeks in adults with overweight or obesity (STEP 1). New England Journal of Medicine, 2021 (Wilding JPH et al.)
- 2.Semaglutide reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes (SELECT). New England Journal of Medicine, 2023 (Lincoff AM et al.)
- 3.Mechanisms of GLP-1: appetite, gastric emptying and glucose regulation. Cell Metabolism, 2018 (Drucker DJ)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not the FDA-approved brand-name products.