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Lipo-B Injection

Weight supportLipotropic

Lipo-B Injection

RxPrescription onlyInjected into the muscle · Twice a week · 50 mg · Weight support · Lipotropic

Starting at $109/mo

A lipotropic blend of methionine, inositol, choline and B12 that supports how the liver processes fat, as part of a physician-guided weight-loss plan.

Choose your plan

Start treatment· $109/mo

Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.

  • Three lipotropic nutrients plus B12 in one weekly injection
  • Supports liver fat metabolism and energy while you lose weight
  • Dosed by your physician alongside your plan

Every plan includes

  • Personalized, physician-guided plan
  • Monthly, 3-month and 6-month plans
  • Dispensed by a US-licensed compounding pharmacy
  • Unlimited protocol adjustments and messaging
  • Ongoing support and check-ins
  • Pause or cancel anytime
  • Reviewed by our in-house physicians
  • Physician-guided care
  • Ongoing, expert support
  • 100% online
  • Free, discreet shipping

What is Lipo-B?

(methionine, inositol, choline and B12)

Lipotropic means fat-moving: methionine, inositol and choline are nutrients the liver uses to package and export fat rather than store it. Choline in particular is essential for building the particles that carry fat out of the liver. B12 is added for energy metabolism. Lipo-B is used as a supporting injection alongside a diet, movement or GLP-1 plan, not as a weight-loss drug on its own.

How it is taken
Injected into the muscle
How often
Twice a week
Dose range
50 mg
Form
Weight support · Lipotropic

4

nutrients in one weekly injection: methionine, inositol, choline and B12

Lipotropic injections have little direct trial evidence for weight loss; they support liver fat metabolism and correct low B12. Your physician places them inside a real plan.

How it works,
week by week.

  1. Day 1

    A US-licensed physician reviews your symptoms, history and, when needed, your B12 level, and chooses the injection and schedule. The kit includes everything you need.

  2. Week 1

    A small intramuscular or subcutaneous injection, weekly to start. It takes under a minute; most people do it at home without trouble.

  3. Weeks 2–4

    If your B12 was low, energy, focus and tingling usually start improving here as stores refill.

  4. Months 2–3

    Your physician checks in, rechecks a level if needed, and stretches the interval or adjusts the blend to match your plan.

  5. Beyond

    Injections support the plan; food, movement and sleep do the work. Your physician helps you decide how long to continue.

What you may notice,
and when.

  • Steadier energy

    the most common change members report

  • Clearer focus

    especially when B12 was low to begin with

  • Support during weight loss

    lipotropic blends alongside a real plan

  • Nerve and blood health

    B12's core job

Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.

Safety first:
what to know before you start.

Important safety information and common side effects

Vitamin B12 and lipotropic injections are generally well tolerated. The most common effects are mild: soreness, redness or a small bruise at the injection site, and occasionally mild nausea, headache or a fishy body odor from choline in larger doses. B12 is water-soluble and excess is excreted. Rarely, injectable B12 can cause an allergic reaction, and it can lower potassium in the first days of correcting a severe deficiency. Not for people with cobalt allergy or Leber's disease (B12) or with a known allergy to any component. Lipotropic blends are not a substitute for a weight-loss plan and are not prescribed during pregnancy or breastfeeding without a specific reason. Stop and seek care for hives, swelling of the face or lips or trouble breathing. Tell your physician about every medication you take, especially metformin, acid reducers and blood thinners.

The research behind
lipotropic injections.

Lipotropic (MIC) injections combine methionine, inositol, choline and B12. We found no randomized trial of the blend for weight loss. The only sources we use here are neutral: fact sheets and reviews of the individual nutrients.

What the studies found

  • No randomized trial has shown fat loss or weight loss from the blend; this is the honest state of the evidence
  • Choline and vitamin B12 are essential nutrients whose established use is correcting deficiency (NIH Office of Dietary Supplements)
  • Methionine is an essential amino acid; that is pharmacology, not a weight-loss result

The products sold as lipotropic injections are compounded blends. The trials of single nutrients do not test the blend, and no trial tests the compounded product for weight loss.

What this does not say

  • No randomized trial shows fat loss from the blend.
  • Single nutrients have established uses in deficiency; that does not extend to fat loss.
  • Injection-related risks such as infection are separate from any benefit.

The research
behind it.

Choline is required to export fat from the liver, and low intake is linked to fatty liver; B12 injections restore energy and blood-cell health when levels are low.

There are no large trials showing lipotropic injections cause weight loss by themselves. Zepym Health prescribes Lipo-B as support inside a plan, and your physician tells you that plainly.

NAD+ and cellular energy:
what the trials showNAD+ precursors, NAD+ injections, glutathione and methylene blue: what has been tested in people, and what has not.Read the researchFatigue:
what to test before you treatB12, thyroid, sleep apnea, hormones and mood: the causes behind tiredness, what the labs show, and how common each one is.Read the research

Getting started
takes a few minutes.

  1. 1

    Connect with a physician

    Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.

  2. 2

    Get your discreet shipment

    If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.

  3. 3

    Receive continuous support

    Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.

Start treatment

Frequently asked questions

Contact support
How do I use Lipo-B?

Injected into the muscle, twice a week. The starting prescription is 1 mL (50 mg) each time. Your physician sets your own dose and it is printed on your label.

How much arrives in each shipment?

1 vial at the starting strength, shipped to your door from a licensed US pharmacy.

Will Lipo-B make me lose weight?

Not on its own. It supports liver fat metabolism and energy, and corrects low B12, while a diet, movement or GLP-1 plan does the actual work. Members who use it report steadier energy during weight loss; the scale change comes from the plan.

How do I inject it?

Usually into the muscle of the upper arm or thigh, or under the skin of the abdomen, once a week to start; your physician shows you and sets the schedule. The kit includes everything.

What are the side effects?

Mostly mild: soreness or a small bruise where you inject, occasional nausea or headache, and with larger choline doses a fishy odor. Serious reactions are rare. Read the safety information above and tell your physician about every medication.

Do I need a blood test?

For B12, often yes: a level tells your physician whether you are deficient and how often you need injections. For lipotropic blends alongside a weight-loss plan, your physician decides from your history. Tests can be arranged locally.

Lipo-B educational content reviewed by our physician

Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine

Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.

More options
in this area.

  • Injection

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    The classic vitamin B12 (cyanocobalamin) injection to restore low B12 and support energy, focus and red blood cell health. Prescribed and dosed by a licensed physician.

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  • Injection

    Lipo-C

    A lipotropic blend with L-carnitine alongside methionine and inositol to support fat metabolism and energy during weight loss. Prescribed and dosed by a licensed physician.

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  • Injection

    MIC / B12

    Methionine, inositol and choline (MIC) with vitamin B12 in one weekly injection to support metabolism alongside a weight-loss plan. Prescribed and dosed by a licensed physician.

    Starting at $109/mo

    Start treatmentLearn more

  • Injection

    MICC / B12

    MIC plus L-carnitine (MICC) with vitamin B12, a lipotropic blend for fat metabolism and energy during weight loss. Prescribed and dosed by a licensed physician.

    Starting at $109/mo

    Start treatmentLearn more

References

  1. 1.Clinical practice: vitamin B12 deficiency. N Engl J Med, 2013
  2. 2.Effects of vitamin B12 supplementation on cognitive function, depressive symptoms and fatigue: a systematic review. Nutrients, 2021
  3. 3.Efficacy of different routes of vitamin B12 supplementation for the treatment of deficiency. Ir J Med Sci, 2024
  4. 4.Effects of L-carnitine supplementation on weight loss and body composition: systematic review and meta-analysis of 37 randomized trials. Clin Nutr ESPEN, 2020
  5. 5.Choline bioavailability, liver fat metabolism and the gut microbiota. Nutrients, 2020

Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.