MOTS-c
RxA mitochondrial-derived peptide studied for metabolic health, insulin sensitivity and exercise capacity, used to support energy and body composition.
- Studied for insulin sensitivity and metabolic balance
- Acts through AMPK, the same energy sensor exercise activates
- Subcutaneous injection, usually a few times a week, dosed by your physician
- Monthly and 3-month plans
- Starting price applies to the 3-month plan
- US-licensed pharmacies
- Pause or cancel anytime
Starting at
$189 / mo
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
What is MOTS-c?
(mitochondrial open reading frame of the 12S rRNA type-c)
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA, the small genome inside the energy-producing parts of your cells. It acts as a signal between mitochondria and the rest of the cell, activating AMPK, the energy sensor that exercise also switches on. Levels fall with age and with metabolic disease.
Get Startedthe peptide your mitochondria make to signal the cell about energy balance
16 aa
MOTS-c improved insulin sensitivity and prevented diet-induced obesity in preclinical studies; human data are early. Prescribed off-label at your physician's discretion.
How growth hormone peptides work
Day 1
A US-licensed physician reviews your goals, history and, when needed, IGF-1 and metabolic labs, and sets your dose. The kit includes everything you need.
Week 1–2
A small subcutaneous injection, usually at night so it lines up with your body's own growth-hormone pulse. Deeper sleep is often the first thing people notice.
Month 1–2
Energy and recovery from training tend to improve next. Your physician checks in and adjusts the dose if needed.
Month 3–6
Body-composition changes take longer: less abdominal fat and more lean mass with consistent training and nutrition.
Beyond
Your physician decides with you how to continue, cycle or pause, guided by labs and how you feel.
Results you can feel
SleepRecoveryDeeper sleep
usually the first change people report
Steadier energy
through the day, without stimulants
Recovery and lean mass
with training, over months
Body composition
gradual, and strongest with tesamorelin for abdominal fat
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Tested for quality, backed by science
We only work with US-licensed pharmacies that prioritize strict quality control standards, so you can count on purity, potency, and safety.
- Pure: compounded to order with pharmaceutical-grade ingredients
- Potent: lab-tested to match the labeled dose
- Sterile: prepared to USP standards by LegitScript-certified pharmacies
Your plan, reviewed
Physician-reviewedDose set by a physician, adjusted at every check-in
Your reviewing physician
Scott Nass, MD
Board-certified family physician. Every growth hormone peptide plan at Zepym Health is reviewed by a licensed physician before anything is prescribed, and adjusted with you as you go.
Meet the teamWhat the research says
The science of growth hormone peptides
In the founding study, MOTS-c targeted skeletal muscle, activated AMPK and improved metabolic homeostasis, reducing obesity and insulin resistance in animals on a high-fat diet.
Human evidence is still emerging, and MOTS-c is not a substitute for a GLP-1 when weight loss is the goal. Your physician places it in context with your labs and history.
Learn moreSubscribe & save
Peptide care that starts with you
Our in-house physicians meet you where you are, and get you to where you want to be.
$189/ mo
Applies to the 3-month plan billed in full ($189/mo on the monthly plan)
What's included
- Personalized, physician-guided plan
- Monthly and 3-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
Personalized for you
Made for your biology
No two people age the same way, so no two treatments are exactly the same. Your plan is guided by your symptoms, your biology, and your priorities. It's a whole “you” approach to living a better, longer life.
Get StartedHow it works
Choosing how you age starts here
- 1
Physician-led
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3100% online
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
MOTS-c educational content reviewed by our physician
Scott Nass, MD
Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
May the source be with you.
We read the research so you don't have to. Here's what the science says.
- 1
Ipamorelin, the first selective growth hormone secretagogue: release of growth hormone without cortisol or prolactin.
Eur J Endocrinol, 1998 - 2
Prolonged stimulation of growth hormone and IGF-1 secretion by CJC-1295 in healthy adults.
J Clin Endocrinol Metab, 2006 - 3
Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?
Clin Interv Aging, 2006 - 4
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
Cell Metab, 2015 - 5
Metabolic effects of a growth hormone-releasing factor (tesamorelin): randomized trial showing reduced visceral fat.
N Engl J Med, 2007 - 6
Effects of tesamorelin on non-alcoholic fatty liver disease: randomised, double-blind, multicentre trial.
Lancet HIV, 2019
Starting at $189 / mo
Get Started