Gonadorelin
RxA copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care.
- Keeps your own testosterone and sperm production going on TRT
- Helps prevent testicular shrinkage during testosterone therapy
- Subcutaneous injection a few times a week, dosed by your physician
- Monthly and 3-month plans
- Starting price applies to the 3-month plan
- US-licensed pharmacies
- Pause or cancel anytime
Starting at
$189 / mo
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
Disclaimer
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
What is gonadorelin?
(go-NAD-o-REL-in)
Gonadorelin is a synthetic copy of gonadotropin-releasing hormone (GnRH), the signal the hypothalamus sends to the pituitary in pulses to release LH and FSH, the hormones that tell the testes to make testosterone and sperm. Testosterone therapy switches that signal off, so the testes go quiet and shrink. Given in pulses, gonadorelin keeps the signal alive, which is why it is prescribed alongside TRT and in some fertility protocols.
Get Startedthe two pituitary hormones gonadorelin keeps flowing, so the testes stay active on testosterone therapy
LH + FSH
Gonadorelin's evidence is strongest for pulsatile use in hypogonadotropic hypogonadism; its use alongside TRT is off-label at your physician's discretion.
How gonadorelin works
Day 1
A US-licensed physician reviews your testosterone plan, fertility goals, history and labs, and sets the dose and schedule. The kit includes everything you need.
Week 1
A small subcutaneous injection, typically a few times a week, in pulses that mimic the brain's own GnRH rhythm.
Month 1–2
LH and FSH signaling stays active. Men on TRT report the testes staying fuller; your physician checks labs as needed.
Month 3
Your physician reviews testosterone, estradiol and, when fertility is the goal, semen parameters, and adjusts the plan.
Beyond
Gonadorelin runs alongside your testosterone plan for as long as preserving your own production matters to you.
Results you can measure
FertilityTesticular functionOwn production preserved
LH and FSH keep signaling on TRT
Testicular size
the shrinkage of TRT is reduced
Fertility option kept
sperm production continues
Easier off-ramp
if you ever stop testosterone therapy
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Tested for quality, backed by science
We only work with US-licensed pharmacies that prioritize strict quality control standards, so you can count on purity, potency, and safety.
- Pure: compounded to order with pharmaceutical-grade ingredients
- Potent: lab-tested to match the labeled dose
- Sterile: prepared to USP standards by LegitScript-certified pharmacies
Your plan, reviewed
Physician-reviewedDose set by a physician, adjusted at every check-in
Your reviewing physician
Scott Nass, MD
Board-certified family physician. Every gonadorelin plan at Zepym Health is reviewed by a licensed physician before anything is prescribed, and adjusted with you as you go.
Meet the teamWhat the research says
The science of gonadorelin
In men with hypogonadotropic hypogonadism, pulsatile gonadorelin induced sperm production earlier than cyclical gonadotropin therapy, confirming it can restart the testes when the brain's signal is missing.
Alongside testosterone therapy, gonadorelin is used to keep LH and FSH signaling alive; that use rests on physiology and clinical experience rather than large trials. Your physician explains the difference.
Learn moreSubscribe & save
Men's health care that starts with you
Our in-house physicians meet you where you are, and get you to where you want to be.
$189/ mo
Applies to the 3-month plan billed in full ($189/mo on the monthly plan)
What's included
- Personalized, physician-guided plan
- Monthly and 3-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
Personalized for you
Made for your biology
No two people age the same way, so no two treatments are exactly the same. Your plan is guided by your symptoms, your biology, and your priorities. It's a whole “you” approach to living a better, longer life.
Get StartedHow it works
Choosing how you age starts here
- 1
Physician-led
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3100% online
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Disclaimer
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Gonadorelin educational content reviewed by our physician
Scott Nass, MD
Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
May the source be with you.
We read the research so you don't have to. Here's what the science says.
- 1
The pulsatile gonadorelin pump induces earlier spermatogenesis than cyclical gonadotropin therapy in congenital hypogonadotropic hypogonadism.
Am J Mens Health, 2019
Starting at $189 / mo
Get Started