Injection
Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Starting at $198/mo
Weight loss
GLP-1s
RxPrescription onlyWeight loss
Starting at $99/mo
A physician-guided GLP-1 treatment plan designed to support appetite regulation, metabolic health, and long-term care beyond the scale.
Choose your plan
Real prices from our pharmacy. Longer plans cost less per month and are billed up front. Pause or cancel anytime.
- Supports the gut-brain signals that help regulate fullness
- Personalized dosing with semaglutide or tirzepatide, guided by licensed physicians
- Ongoing care, physician messaging, and dose guidance as your body responds
Every plan includes
- Personalized, physician-guided plan
- Semaglutide or tirzepatide, with B12 or glycine
- Monthly, 3-month and 6-month plans
- Same price at every dose, no dose upcharges
- Dispensed by a US-licensed compounding pharmacy
- Unlimited dose adjustments and messaging
- Pause or cancel anytime
- Physician-guided care
- Ongoing, expert support
- 100% online
- Free, discreet shipping
What are GLP-1s?
(glucagon-like peptide-1)
The body naturally makes GLP-1 after you eat. It is one of the signals that helps tell the brain “we've had enough,” while slowing digestion and supporting steadier blood sugar after meals. GLP-1 medications are designed to mimic that natural hormone signal. By helping that fullness signal stay active longer, they may support appetite regulation, steadier eating patterns, and metabolic health.
- Form
- Weight loss
15–21%
Average body weight reduction in the pivotal clinical trials of brand-name semaglutide and tirzepatide
About 15% with once-weekly semaglutide over 68 weeks (STEP 1) and up to about 21% with tirzepatide over 72 weeks (SURMOUNT-1), both with lifestyle changes. Compounded GLP-1s are not the brand-name products and were not studied in those trials; individual results vary.
Semaglutide or tirzepatide?
Both are once-weekly injections that quiet appetite and slow digestion. The difference is how many hormones each one imitates, how much weight people lost with each in clinical trials, and the price. Your physician helps you choose, and you can switch later.
| SemaglutideThe active ingredient of Ozempic and Wegovy | TirzepatideThe active ingredient of Mounjaro and Zepbound | |
|---|---|---|
| How it works | Imitates one hormone: GLP-1 | Imitates two hormones: GLP-1 and GIP |
| Average weight loss in its own trial | About 15% of body weight in 68 weeks (STEP 1) | Up to about 21% in 72 weeks, at the highest dose (SURMOUNT-1) |
| Compared head to head | 13.7% in 72 weeks (SURMOUNT-5) | 20.2% in 72 weeks (SURMOUNT-5) |
| How often | Once a week, under the skin | Once a week, under the skin |
| Most common side effects | Nausea, constipation, diarrhea; mostly when the dose goes up | The same kind: nausea, constipation, diarrhea when the dose goes up |
| Often chosen when | It is your first GLP-1, you want the lower price, or the longest track record | You have more weight to lose, or semaglutide was not enough |
Trial results are for the brand-name medicines, with diet and exercise, in adults with obesity or overweight and no diabetes. Compounded semaglutide and tirzepatide are not the brand-name products and were not studied in those trials; individual results vary. Neither is used with a personal or family history of medullary thyroid cancer or MEN 2.
How it works,
week by week.
Day 1
A US-licensed physician reviews your health profile, goals and treatment history to decide whether semaglutide or tirzepatide is the right starting point, and at what dose.
7 Days
Your first weekly injection. Appetite usually quiets within days; some nausea in the first weeks is common and fades as the dose settles.
30 Days
Fullness comes sooner and cravings soften. Your physician checks how you feel before any dose increase.
6 Months
Weight loss builds steadily with the plan, food and movement. Doses are adjusted at your check-ins.
1 Year and Beyond
Maintenance is part of the plan: your physician decides with you how to hold your results or taper.
What you may notice,
and when.
Weight loss
steady and sustained, with your physician adjusting the dose
Appetite regulation
the most common change members report in their first weeks
Metabolic health
steadier blood sugar after meals
Energy and tolerance
B12 for energy or glycine for easier first weeks, your choice
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
Safety first:
what to know before you start.
Are GLP-1s right for you?
GLP-1 medications are prescribed based on your BMI, your health history and your goals. Find your BMI on the chart to see whether you're within the usual range for treatment, then let your physician decide.
| BMI | Is GLP-1 right for me? |
|---|---|
| 24.9 or less | No |
| 25.0 to 29.9 | Case-by-case (with a weight-related condition) |
| 30.0 or above | Likely |
This chart is not a medical diagnosis. Your physician approves or declines a prescription at their discretion after reviewing your unique health profile; approval is not guaranteed by these criteria.
Important safety information and common side effects
GLP-1 medications can cause nausea, vomiting, diarrhea, constipation, stomach pain, reduced appetite, fatigue and injection-site reactions, most often in the first weeks and when the dose goes up. Stop and seek care for severe stomach pain (possible pancreatitis or gallbladder problems), signs of an allergic reaction, or vision changes if you have diabetes. GLP-1 medications carry a boxed warning about thyroid C-cell tumors seen in rodents: do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for use in pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about diabetes medication, insulin and every medication you take.
The research
behind it.
GLP-1 is a hormone the body already makes after eating, telling the brain “we've had enough” while slowing digestion and steadying blood sugar. GLP-1 medications amplify that same signal for a full week per dose; tirzepatide adds the GIP signal on top.
In the pivotal trials, brand-name semaglutide produced about 15% weight loss and tirzepatide up to about 21%, and semaglutide also reduced major cardiovascular events in people with obesity without diabetes (SELECT). Compounded versions are prescribed by your physician when appropriate and are not the brand-name products.
GLP-1 beyond the scale:
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
what the research showsHeart, kidneys, liver, sleep and joints: the trials, with their numbers and their limits.Read the researchMicrodosing GLP-1:
what we know, and what we don’tLower doses are everywhere online. Here is what has actually been studied, and how our physicians use dose.Read the research
Getting started
takes a few minutes.
- 1
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
- 2
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
- 3
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Frequently asked questions
Contact supportWhat are GLP-1s and how do they work?
GLP-1s are medications that mimic a hormone your body makes after eating. They tell your brain you're full, slow how fast your stomach empties and steady blood sugar after meals, so you feel satisfied with less food and eating less becomes sustainable rather than a fight.
What are the side effects of GLP-1 medications?
Nausea, constipation, diarrhea and fatigue are the most common, usually in the first weeks and after a dose increase, and they fade as your body adjusts. Serious but rare risks include pancreatitis and gallbladder problems; read the safety information above and tell your physician about any history of pancreatitis or thyroid cancer.
How long does it take to see results with GLP-1?
Appetite usually quiets within the first days. Weight loss builds week by week as your physician raises the dose at your check-ins; in the brand-name trials, results kept building over more than a year. Your pace depends on your dose, your food and your movement.
Semaglutide or tirzepatide: which one is right for me?
Semaglutide acts on GLP-1; tirzepatide acts on GLP-1 and GIP and produced the larger weight loss in trials. Your physician chooses with you based on your BMI, your history, your goals and your budget, and can switch you later if needed.
What do B12 and glycine add?
Vitamin B12 supports energy and red blood cell production, which helps offset the tiredness some people feel when eating less. Glycine is an amino acid that supports steadier digestion and sleep; many members tolerate the first weeks better with it.
GLP-1 educational content reviewed by our physician
Scott Nass, MD Doctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
More options
in this area.
Injection
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Starting at $99/mo
Injection
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Starting at $198/mo
Injection
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Starting at $99/mo
References
- 1.Once-weekly semaglutide 2.4 mg produced a mean weight loss of about 15% over 68 weeks in adults with overweight or obesity (STEP 1). New England Journal of Medicine, 2021 (Wilding JPH et al.)
- 2.Once-weekly tirzepatide produced mean weight loss of up to about 21% over 72 weeks in adults with obesity (SURMOUNT-1). New England Journal of Medicine, 2022 (Jastreboff AM et al.)
- 3.Semaglutide reduced major adverse cardiovascular events in adults with overweight or obesity without diabetes (SELECT). New England Journal of Medicine, 2023 (Lincoff AM et al.)
- 4.Mechanisms of GLP-1: appetite, gastric emptying and glucose regulation. Cell Metabolism, 2018 (Drucker DJ)
- 5.Head to head in adults with obesity without diabetes, tirzepatide produced a mean weight loss of 20.2% and semaglutide 13.7% at 72 weeks (SURMOUNT-5). New England Journal of Medicine, 2025 (Aronne LJ et al.)
Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not the FDA-approved brand-name products.