Into the muscle of the thigh or buttock, every one to two weeks, at the interval your physician sets. It takes a minute; the kit includes everything and your physician shows you how.

Do I need progesterone too?

If you have a uterus, yes: estrogen alone thickens the uterine lining, and a progestogen protects it. Your physician includes it in your plan. After a hysterectomy, estrogen alone is standard.

Is hormone therapy safe?

For most healthy women under 60 or within 10 years of menopause, the benefits outweigh the risks, according to the Menopause Society. Risks rise with age, time since menopause, smoking and personal history. Your physician goes through yours before prescribing and reviews the plan at least yearly.

MenopauseHormone therapy

Estradiol Cypionate

Long-acting estradiol injection for hot flashes, night sweats, sleep and mood changes of menopause and perimenopause, and for gender-affirming hormone therapy. One injection every one to two weeks.

The most effective treatment for hot flashes and night sweats
Steady levels from one injection every 1–2 weeks
Prescribed and dosed by a physician who reviews your history

One-time purchase, 90-day supply
Reorder when you need it
US-licensed pharmacies
No subscription

Starting at

$189 / mo

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Physician-guided care
Ongoing, expert support
100% online
Free, discreet shipping

Who is estradiol injection for?
Women with bothersome hot flashes, night sweats, sleep or mood changes of perimenopause or menopause who have no contraindications, and adults on feminizing gender-affirming hormone therapy. It is not for people with a history of breast cancer, blood clots, stroke or unexplained bleeding. Your physician reviews your history and decides.
How do I inject it?
Into the muscle of the thigh or buttock, every one to two weeks, at the interval your physician sets. It takes a minute; the kit includes everything and your physician shows you how.
Do I need progesterone too?
If you have a uterus, yes: estrogen alone thickens the uterine lining, and a progestogen protects it. Your physician includes it in your plan. After a hysterectomy, estrogen alone is standard.
Is hormone therapy safe?
For most healthy women under 60 or within 10 years of menopause, the benefits outweigh the risks, according to the Menopause Society. Risks rise with age, time since menopause, smoking and personal history. Your physician goes through yours before prescribing and reviews the plan at least yearly.

Estradiol is a prescription hormone with real benefits and real risks, which is why a physician reviews your history first. Common, usually temporary effects include breast tenderness, bloating, nausea, headache, spotting or breakthrough bleeding, and soreness at the injection site. Estrogen therapy increases the risk of blood clots, stroke and gallbladder disease, and, when used with a uterus, must be paired with a progestogen to protect the uterine lining. It is not prescribed with a history of breast or estrogen-sensitive cancer, blood clots, stroke or heart attack, liver disease, unexplained vaginal bleeding, or during pregnancy. Smoking raises the clot risk further. Seek care immediately for chest pain, shortness of breath, leg swelling, sudden severe headache, vision changes or unexplained bleeding. Tell your physician about every medication you take.

Disclaimer

Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.

What is estradiol cypionate?

(es-tra-DYE-ol SIP-ee-oh-nate)

Estradiol is the main estrogen your ovaries make before menopause. Estradiol cypionate is estradiol bound to a fatty acid so that, injected into muscle, it releases slowly over one to two weeks. It replaces the estrogen that falls at menopause, which is what drives hot flashes, night sweats, vaginal dryness, disrupted sleep and bone loss. It is also a standard option in feminizing gender-affirming hormone therapy. This is a 90-day supply bought once.

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reduction in hot-flash frequency with estrogen therapy versus placebo, in the Cochrane review of 24 randomized trials

~75%

Hormone therapy is most favorable when started before age 60 or within 10 years of menopause, in people without contraindications. Your physician reviews that with you.

How estradiol therapy works

A US-licensed physician reviews your symptoms, history, risk factors and, when needed, labs, and sets your dose. The 90-day kit ships discreetly to your door.

Day 1
A US-licensed physician reviews your symptoms, history, risk factors and, when needed, labs, and sets your dose. The 90-day kit ships discreetly to your door.
Weeks 1–2
One intramuscular injection every one to two weeks. Hot flashes and night sweats usually ease within the first two to four weeks.
Month 1–2
Sleep and mood follow as levels steady. Your physician checks in and adjusts the dose or interval to your response.
Month 3
Time to reorder. Your physician reviews how you feel, any bleeding or side effects, and confirms the plan for the next 90 days.
Beyond
Hormone therapy is reviewed at least yearly: dose, benefits, risks and whether to continue. Your physician decides with you.

Results you can feel

Fewer hot flashesBetter sleep

Fewer hot flashes
the change estradiol is best known for
Uninterrupted sleep
as night sweats settle
Steadier mood
reported by many as levels stabilize
Bone protection
estrogen slows the bone loss of menopause

Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.

Tested for quality, backed by science

We only work with US-licensed pharmacies that prioritize strict quality control standards, so you can count on purity, potency, and safety.

Pure: compounded to order with pharmaceutical-grade ingredients
Potent: lab-tested to match the labeled dose
Sterile: prepared to USP standards by LegitScript-certified pharmacies

Your plan, reviewed

Physician-reviewed

Dose set by a physician, adjusted at every check-in

Your reviewing physician

Scott Nass, MD

Board-certified family physician. Every hormone therapy plan at Zepym Health is reviewed by a licensed physician before anything is prescribed, and adjusted with you as you go.

Meet the team

What the research says

The science of menopausal hormone therapy

The 2022 Menopause Society position statement confirms hormone therapy as the most effective treatment for hot flashes and night sweats, with a favorable balance of benefit and risk when started under 60 or within 10 years of menopause.

Long-term follow-up of the Women's Health Initiative found no increase in all-cause mortality over 18 years among women who used hormone therapy. Your physician goes through your personal risk factors before prescribing.

Learn more

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Hormone care that starts with you

Our in-house physicians meet you where you are, and get you to where you want to be.

$189/ mo

One-time price for a 90-day supply

What's included

Personalized, physician-guided plan
90-day supply, no subscription
Dispensed by a US-licensed compounding pharmacy
Unlimited physician messaging
Reorder whenever you need it
Reviewed by our in-house physicians

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Personalized for you

Made for your biology

No two people age the same way, so no two treatments are exactly the same. Your plan is guided by your symptoms, your biology, and your priorities. It's a whole “you” approach to living a better, longer life.

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How it works

Choosing how you age starts here

1
Physician-led
Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2
Fast, discreet shipping
Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3
100% online
Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.

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Disclaimer

The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.

Estradiol educational content reviewed by our physician

Scott Nass, MD

Doctor of Medicine, board-certified in Family Medicine

Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.

Frequently asked questions

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Answer a few questions and take your first step to living well.

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Have more questions?

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May the source be with you.

We read the research so you don't have to. Here's what the science says.

1
The 2022 hormone therapy position statement of The North American Menopause Society.
Menopause, 2022
2
Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials.
JAMA, 2017
3
Eligibility criteria for menopausal hormone therapy: a position statement from a consortium of scientific societies.
Maturitas, 2022
4
Oral oestrogen and combined oestrogen/progestogen therapy versus placebo for hot flushes: Cochrane review.
Cochrane Database Syst Rev, 2004

Starting at $189 / mo

Get Started

Estradiol Cypionate

Frequently asked questions

Important safety information and common side effects

What is estradiol cypionate?

How estradiol therapy works

Day 1

Weeks 1–2

Month 1–2

Month 3

Beyond

Tested for quality, backed by science

Scott Nass, MD

The science of menopausal hormone therapy

Hormone care that starts with you

Made for your biology

Choosing how you age starts here

Connect with a physician

Get your discreet shipment

Receive continuous support

Frequently asked questions

01Who is estradiol injection for?

02How do I inject it?

03Do I need progesterone too?

04Is hormone therapy safe?

Ready to start?

Have more questions?

May the source be with you.