Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Injected under the skin · Once a week
Weight lossGLP-1/GIPB vitamin
Tirzepatide + B6
Weekly tirzepatide (dual GLP-1/GIP) with vitamin B6 to support metabolism and energy. B6 acts as a cofactor in amino acid and energy metabolism, complementing tirzepatide's appetite control.
- Dual GLP-1/GIP for appetite and metabolic health
- B6 supports amino acid metabolism and energy
- Once-weekly injection with vitamin support
- Monthly$399/mo
- Every 3 months$699 billed up front$233/mo
- Every 6 monthsBest value$1,250 billed up front$208/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Injected under the skin
- How often
- Once a week
- Each shipment
- 1 vial
- Strengths
- 4 options · 2.5–10 mg tirzepatide
What is Tirzepatide + B6?
(dual GLP-1/GIP plus B vitamin)
Tirzepatide is a dual GLP-1/GIP receptor agonist; B6 (pyridoxine) is an essential cofactor in protein and energy metabolism. Together, tirzepatide suppresses appetite while B6 supports your body's ability to process nutrients and maintain energy during weight loss.
What's in it
- TirzepatideGLP-1 + GIP: appetite and blood sugar
- B6Vitamin B6: may ease nausea
Dual + B6
GLP-1/GIP appetite control plus metabolic support
Tirzepatide reduces hunger and improves metabolic markers. B6 optimizes your metabolism's use of amino acids from the protein you eat. The combination supports both weight loss and metabolic health.
Is it right for you?
Who it's for
People starting tirzepatide who are worried about nausea in the first weeks.
What sets it apart
Vitamin B6 is a long-used remedy for nausea; here it rides in the same injection.
Worth knowing before you start
Small meals, less fat and stopping at the first sign of fullness control nausea better than anything in the vial.
Results you can see and feel
Weight loss
faster and more sustained with dual GLP-1/GIP
Energy and metabolism
additives maintain vitality during weight loss
Better sleep and recovery
glycine and B12 support rest and resilience
Whole-body support
comprehensive approach to sustainable results
How tirzepatide combination therapy works
Day 1
A US-licensed physician reviews your health and goals. Explains tirzepatide's dual GLP-1/GIP action and how additives support energy, metabolism, and recovery.
1Week 1
First injection. Appetite quiets quickly. Additives begin supporting your energy and recovery systems.
2Weeks 2–4
Significant fullness and reduced cravings. Additives (energy, sleep, metabolism support) kick in. Your physician checks in before dose adjustments.
3Months 2–3
Steady, accelerating weight loss. Additive benefits (sustained energy, improved sleep, muscle support) make the journey comfortable.
4Beyond
Maintenance: your physician adjusts doses to hold results. Additives support long-term vitality and metabolic health.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Injected under the skin
- Dose
- 25 units (2.5 mg tirzepatide)
- How often
- Once a week
- Each shipment
- 1 vial
- Pharmacy label
- Inject 25 units (2.5 mg tirzepatide) subcutaneously once weekly for 4 weeks. Discard any remaining medication.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a week
Strengths the pharmacy carries
- 20 mg (10 mg/mL)
- 10 mg (10 mg/mL)
- 40 mg (10 mg/mL)
- 30 mg (10 mg/mL)
The science of tirzepatide combinations
Tirzepatide (SURMOUNT trials) produces up to 21% mean weight loss. B6 is essential for metabolism; deficiency impairs energy and muscle function.
Together, they target appetite (tirzepatide) and optimal metabolism (B6), supporting sustainable weight loss with maintained energy and muscle.
Learn moreImportant safety information and common side effects
Tirzepatide plus additives carries tirzepatide's safety profile: nausea, diarrhea, constipation, reduced appetite, and fatigue are common in early weeks. Additives (B6, L-carnitine, glycine, methylcobalamin) are well-tolerated. Do not use with medullary thyroid carcinoma history or MEN 2. Not for pregnancy or breastfeeding, or with active pancreatitis. Tell your physician about all medications, diabetes drugs, and any kidney or pancreatic disease. Stop and seek care for severe abdominal pain, allergic reactions, or signs of pancreatitis.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Tirzepatide + B6 educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Tirzepatide + B6?
Injected under the skin, once a week. The starting prescription is 25 units (2.5 mg tirzepatide) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Tirzepatide + B6 come in?
The pharmacy carries 4: 10 mg (10 mg/mL), 20 mg (10 mg/mL), 30 mg (10 mg/mL), 40 mg (10 mg/mL). Your physician chooses which one you get.
What exactly is in it?
Tirzepatide, B6.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Why add B6 to tirzepatide?
B6 supports protein and energy metabolism. During weight loss, especially if eating less protein, B6 ensures your body processes nutrients efficiently. It helps prevent the energy dips some people experience.
Is tirzepatide more powerful than semaglutide?
Tirzepatide (dual GLP-1/GIP) produced larger weight loss in trials (~21% vs. ~15% for semaglutide). However, 'better' depends on your individual response. Your physician will recommend based on your health profile.
Can I switch between tirzepatide and semaglutide?
Yes. If one doesn't work as well, your physician can switch you to the other. Doses differ between the two, so the change is made carefully.
Do additives interact with tirzepatide?
No significant interactions. B6, L-carnitine, glycine, and methylcobalamin are natural compounds that complement tirzepatide's action. Your physician monitors overall response.
Tirzepatide with nutrients for complete results.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Injection
from $129/mo
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Once-weekly tirzepatide 2.4 mg produced mean weight loss of up to 21% over 72 weeks in adults with obesity (SURMOUNT-1).
NEJM, 2022 (Jastreboff AM et al.) - 2
Methylcobalamin and energy metabolism: B12 as an essential cofactor in mitochondrial function.
J Clin Biochem Nutr, 2008
Tirzepatide + B6from $208/mo