Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Injected under the skin · Once a week
Weight lossGLP-1B12 + amino acid
Semaglutide + Methylcobalamin + Glycine
Weekly semaglutide with methylcobalamin (active B12) and glycine to support energy, sleep, and digestion during weight loss. A triple approach to appetite, energy, and recovery.
- Semaglutide for appetite and weight loss
- Methylcobalamin for energy and nerve function
- Glycine for sleep quality and digestive comfort
- Monthly$279/mo
- Every 3 months$497 billed up front$166/mo
- Every 6 monthsBest value$774 billed up front$129/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Injected under the skin
- How often
- Once a week
- Each shipment
- 1 vial
- Strengths
- 3 options · 0.4–2.5 mg semaglutide
What is this combination?
(GLP-1 plus B12 and amino acid)
Methylcobalamin is an active form of B12 that supports energy production and nerve health. Glycine is an amino acid that promotes sleep and supports muscle recovery. Together with semaglutide, they address appetite (GLP-1), energy (B12), and sleep (glycine).
What's in it
- SemaglutideGLP-1: quiets appetite, slows digestion
- MethylcobalaminVitamin B12: energy metabolism
- GlycineAmino acid: supports lean mass
Triple support
appetite, energy, and sleep during weight loss
Semaglutide reduces hunger; methylcobalamin supports energy; glycine improves sleep quality. Many people experience fatigue and sleep disruption early in weight loss; this combination targets those common challenges.
Is it right for you?
Who it's for
People who prefer the active form of B12 and want glycine in the same weekly injection.
What sets it apart
Methylcobalamin is B12 the body can use without converting it; the semaglutide is the same as in the other vials.
Worth knowing before you start
Three vial sizes exist. A larger vial is not a higher dose: follow the units on your label.
Results you can feel
Weight loss
steady with semaglutide appetite control
Energy and stamina
supported by B12, L-carnitine, or methylcobalamin
Better sleep
glycine improves sleep quality from week one
Comfort
additives smooth the first weeks of weight loss
How combination weight loss works
Day 1
A US-licensed physician reviews your goals and health. Explains how semaglutide works and what each additive (energy, sleep, metabolism) brings to your plan.
1Week 1
First injection. Appetite often quiets within days. Additives (B12, glycine, L-carnitine) begin supporting your energy and recovery.
2Weeks 2–4
Fullness comes sooner, cravings soften. Energy and sleep improve as the additives settle in. Your physician checks in before any dose adjustment.
3Months 2–3
Weight loss builds steadily. Additive benefits (sustained energy, better sleep, muscle support) help you feel good while losing weight.
4Beyond
Maintenance: your physician adjusts doses to hold your results. Long-term use of additives supports sustained energy and health.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Injected under the skin
- Dose
- 8 units (0.4 mg semaglutide)
- How often
- Once a week
- Each shipment
- 1 vial
- Pharmacy label
- Inject 8 units (0.4 mg semaglutide) subcutaneously once weekly for 4 weeks. Discard any remaining medication.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a week
Strengths the pharmacy carries
- 5 mg (5 mg / 1 mg / 10 mg/mL)
- 10 mg (5 mg / 1 mg / 10 mg/mL)
- 7.5 mg (5 mg / 1 mg / 10 mg/mL)
The science of combination therapy
Semaglutide is well-established for weight loss. Methylcobalamin is a cofactor in energy and nerve function. Glycine improves sleep architecture and supports muscle repair.
The combination targets multiple aspects of wellness during weight loss. Individual response varies based on starting B12 status and sleep patterns.
Learn moreImportant safety information and common side effects
Semaglutide plus additives carries the safety profile of semaglutide itself: nausea, vomiting, diarrhea, constipation, reduced appetite, fatigue, and injection-site reactions are common in early weeks. The additives (L-carnitine, methylcobalamin, glycine) are generally well-tolerated. Do not use with medullary thyroid carcinoma history or MEN 2. Not for pregnancy or breastfeeding, or with active pancreatitis. Tell your physician about all medications, diabetes drugs, and any kidney or pancreatic disease. Stop and seek care for severe abdominal pain, allergic reactions, or signs of pancreatitis.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Semaglutide + Methylcobalamin + Glycine educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Semaglutide + Methylcobalamin + Glycine?
Injected under the skin, once a week. The starting prescription is 8 units (0.4 mg semaglutide) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Semaglutide + Methylcobalamin + Glycine come in?
The pharmacy carries 3: 5 mg (5 mg / 1 mg / 10 mg/mL), 7.5 mg (5 mg / 1 mg / 10 mg/mL), 10 mg (5 mg / 1 mg / 10 mg/mL). Your physician chooses which one you get.
What exactly is in it?
Semaglutide, Methylcobalamin, Glycine.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Why combine semaglutide with B12 and glycine?
Weight loss often brings early fatigue and sleep changes. B12 supports energy production; glycine improves sleep. The combination helps you feel better while losing weight. If your energy and sleep normalize, your physician may adjust doses.
Do I need all three additives?
Not necessarily. Your physician will suggest the combination that matches your needs. If fatigue is your main concern, B12 and L-carnitine help. If sleep is the issue, glycine is the focus. You can change your combination over time.
Are additives safe long-term?
Yes. B12, glycine, and L-carnitine are natural compounds your body uses daily. They are safe at the doses used here, even for years of use. Your physician monitors you at regular check-ins.
What if additives don't help?
Some people feel a difference immediately; others take weeks. If you don't notice energy or sleep improvements after 4–6 weeks, your physician may adjust doses or try a different additive combination.
Semaglutide with nutrients for better results.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Injection
from $129/mo
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Semaglutide for weight loss (STEP 1): once-weekly GLP-1 resulted in mean 15% weight loss over 68 weeks.
NEJM, 2021 (Wilding JPH et al.) - 2
L-carnitine supplementation improves energy metabolism and exercise performance in metabolic studies.
Nutrients, 2021 (Malaguarnera M)
Semaglutide + Methylcobalamin + Glycinefrom $129/mo