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CholesterolHeart healthLDL
Ezetimibe Tablets
Ezetimibe: FDA-approved oral tablet that lowers LDL cholesterol by blocking intestinal cholesterol absorption. Works by a different mechanism than statins; often combined with statin therapy for additive effect.
- Blocks intestinal cholesterol absorption; lowers LDL 15-20%
- Different mechanism from statins; effective as monotherapy or combined
- Oral tablet, once daily with or without food
- Monthly$89/mo
- Every 3 months$207 billed up front$69/mo
- Every 6 monthsBest value$354 billed up front$59/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 tablets
- Strength
- 10 mg
What is ezetimibe?
(zetia, non-statin cholesterol lowering)
Ezetimibe blocks NPC1L1, a cholesterol transporter in your intestinal wall. This prevents dietary cholesterol (which you ingest and which your body makes and recycles) from entering the bloodstream. Less intestinal cholesterol absorption means lower LDL. It does not inhibit cholesterol synthesis the way statins do; it stops it from being absorbed. This makes it an ideal partner for statin therapy or for people who cannot tolerate statins.
What's in it
- EzetimibeBlocks cholesterol absorption
15-20%
LDL reduction with ezetimibe monotherapy
Combined with a statin, the LDL reduction is additive, often reaching 40-50%. Ezetimibe is FDA-approved for hypercholesterolemia and is covered by most insurance.
Is it right for you?
Who it's for
People with high LDL who do not tolerate statins, or need more than a statin.
What sets it apart
A prescription medicine, not a supplement. It blocks cholesterol absorption in the gut.
Worth knowing before you start
A cholesterol test before and three months after tells you if it works.
What to expect
Lower LDL
cholesterol reduction measured by lipid panel
Stable HDL and triglycerides
ezetimibe does not typically lower good cholesterol
Reduced cardiovascular risk
lower LDL correlates with reduced event risk
Consistent dosing
once-daily tablet fits easily into routine
How ezetimibe works
Day 1
Your physician reviews your LDL level, cardiovascular risk, diet, and current medications. Discusses how ezetimibe fits into your cholesterol plan.
1Week 1
Take your ezetimibe tablet once daily, with or without food. If combined with a statin, take both at the same time.
2Weeks 4-6
Ezetimibe begins lowering LDL as it blocks intestinal cholesterol absorption. No symptoms to notice; the effect is measured by lab.
3Week 6-8
First lipid panel: LDL, HDL, triglycerides, and total cholesterol. Your physician may adjust ezetimibe dose or add or adjust the statin based on results.
4Beyond
Ezetimibe works best on a stable dose. Annual lipid panels and cardiovascular check-ins ensure your plan remains optimal.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 tablet (10 mg)
- How often
- Once a day
- Each shipment
- 30 tablets
- Pharmacy label
- Take 1 tablet (10 mg) by mouth once daily, with or without food, for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of cholesterol management
Ezetimibe consistently lowers LDL and lowers triglycerides slightly. Studies show additive benefit when combined with statins, reducing need for high-dose statin therapy.
Ezetimibe is well tolerated; side effects are rare. Long-term cardiovascular benefit is demonstrated in combination with statins in multiple trials.
Learn moreImportant safety information and common side effects
Ezetimibe is very well tolerated. Side effects are rare; the most common are mild headache and GI upset. Do not use ezetimibe if you have active liver disease or if you are taking a statin and have elevated liver enzymes. Tell your physician about all medications and any history of muscle pain or weakness (myopathy risk is higher when ezetimibe is combined with a statin). Stop and seek care for severe muscle pain, dark urine, or signs of liver damage (jaundice, abdominal pain, nausea).
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Ezetimibe educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Ezetimibe Tablets?
Taken by mouth, once a day. The starting prescription is 1 tablet (10 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
30 tablets at the starting strength, shipped to your door from a licensed US pharmacy.
Why combine ezetimibe with a statin?
Statins reduce cholesterol made by your liver; ezetimibe reduces dietary cholesterol absorbed from your gut. Combined, they hit cholesterol from two angles, often lowering LDL more than either alone. This can reduce the need for very high statin doses, which some people do not tolerate well.
How long does ezetimibe take to work?
Ezetimibe begins reducing LDL within the first week; peak effect is reached around 2 weeks. Full blood lipid response takes 4-6 weeks. Your physician checks labs at 6-8 weeks to confirm efficacy.
Can I take ezetimibe with a statin?
Yes. Ezetimibe and statins work by different mechanisms, so their LDL-lowering effects add together. The combination is often chosen to reduce the need for very high statin doses.
What if my LDL is not low enough?
Your physician may increase the ezetimibe dose, increase the statin dose, or add a third agent (like a PCSK9 inhibitor). Discuss your LDL goal and how to reach it.
Does ezetimibe have long-term side effects?
No. Ezetimibe is well tolerated long-term. Regular liver enzyme monitoring is recommended if combined with a statin. Report any muscle pain to your physician promptly.
Cholesterol control for heart health.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Ezetimibe as monotherapy or in combination with statins for hypercholesterolemia.
Am J Cardiol, 2008 - 2
Cardiovascular outcomes with ezetimibe in statin-treated patients.
N Engl J Med, 2015
Ezetimibe Tabletsfrom $59/mo