Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Dissolved under the tongue · Once a day
Weight lossGLP-1/GIPOral
Tirzepatide ODT
Oral tirzepatide tablet taken sublingually, formulated to mimic the weekly GLP-1/GIP injection. Early-stage evidence; absorption is lower and variable. Physician-supervised dosing.
- Dual GLP-1/GIP in oral form
- Sublingual for enhanced absorption
- Dose adjusted by your physician
- Monthly$349/mo
- Every 3 months$957 billed up front$319/mo
- Every 6 monthsBest value$1,734 billed up front$289/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Dissolved under the tongue
- How often
- Once a day
- Each shipment
- 1 bottle
- Strengths
- 8 options · 3–12 mg
What is Tirzepatide ODT?
(orally disintegrating tablet, dual GLP-1/GIP)
Tirzepatide ODT is a compounded tablet that dissolves under the tongue to deliver the dual hormone-mimicking effect of GLP-1 and GIP. Oral tirzepatide has lower and more variable absorption than injected forms.
What's in it
- TirzepatideGLP-1 + GIP: appetite and blood sugar
Early-stage
oral dual agonist; limited human data
Sublingual tirzepatide absorbs via the oral mucosa. Bioavailability is lower and more variable than injections. Your physician starts conservatively and increases based on your tolerance and response.
Is it right for you?
Who it's for
People who want tirzepatide and rule out injections.
What sets it apart
A daily tablet under the tongue. Absorption this way has not been studied the way the injection has, so the effect can be weaker.
Worth knowing before you start
Give it eight weeks at a stable dose before judging it. If it falls short, the injection is the next step, not a higher tablet.
What to expect
Weight loss
pace depends on dose absorption and individual response
Appetite reduction
may appear quickly or gradually
Energy changes
some report early fatigue as eating patterns shift
Close monitoring
frequent check-ins ensure safety given limited data
How oral GLP-1 care works
Day 1
A US-licensed physician reviews your goals, medical history, and medications. Discusses how oral GLP-1 formulations work and the limited human evidence.
1Week 1
Start your first dose sublingually. Keep the tablet or liquid under your tongue as instructed. Appetite may quiet quickly or gradually; effects are unpredictable.
2Weeks 2–4
Your physician checks in to assess how you feel: appetite, digestion, energy, and early weight changes. Dose may be adjusted based on your response.
3Months 2–3
Weight loss builds as your body adjusts. Your physician continues to monitor and refines your dose for optimal effect.
4Beyond
Maintenance dosing continues; your physician decides with you how to hold or adjust your dose over time.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Dissolved under the tongue
- Dose
- 1 tablet (3 mg)
- How often
- Once a day
- Each shipment
- 1 bottle
- Pharmacy label
- Place 1 tablet (3 mg) under the tongue once daily, 30 minutes before food or drink, for 30 days. Let it dissolve; do not chew or swallow it whole.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 6 mg
- 10 mg
- 4 mg
- 3 mg
- 5 mg
- 12 mg
- 7 mg
- 8 mg
The science of oral GLP-1
Injected tirzepatide (the brand-name product Zepbound) produces the largest weight loss in clinical trials. Oral tirzepatide is experimental; human absorption data are very limited.
Expected effects include appetite reduction and improved metabolic markers, but onset may be slower and less predictable than injection. Your physician monitors closely.
Learn moreImportant safety information and common side effects
Oral semaglutide and tirzepatide are experimental formulations with limited human data. Common effects include nausea, diarrhea, constipation, and reduced appetite, often in the first weeks as absorption settles. Absorption is variable; blood levels may be unpredictable. Do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about all medications, diabetes drugs, and any history of kidney or pancreatic disease. Stop and seek care for severe abdominal pain, signs of pancreatitis, allergic reactions, or vision changes if diabetic.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Tirzepatide ODT educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Tirzepatide ODT?
Dissolved under the tongue, once a day. The starting prescription is 1 tablet (3 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Tirzepatide ODT come in?
The pharmacy carries 8: 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 10 mg, 12 mg. Your physician chooses which one you get.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
How does oral tirzepatide compare to the shot?
Injected tirzepatide has proven efficacy and predictable blood levels. Oral tirzepatide is newer and less studied. Your physician may prescribe a higher initial dose to account for variable absorption.
Why oral instead of injection?
Oral forms avoid needles. Be aware: absorption is unpredictable and lower than injections, so effects are less reliable. Your physician will adjust your dose frequently as you respond.
What if absorption is poor?
If you see minimal effect after 4–6 weeks at a good dose, your physician may increase the dose, try a different formulation, or recommend switching to injected GLP-1 for better reliability.
How often will I need adjustments?
Frequently at first, every 1–2 weeks in the first month, to find your effective dose. Once stable, check-ins may space out to monthly or every 2 months.
Can I switch between oral and injection?
Yes. If oral doesn't work well or you need more predictable results, your physician can switch you to injected semaglutide or tirzepatide.
Oral GLP-1, experimental option.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Injection
from $129/mo
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Oral semaglutide 2.4 mg once daily with permeation enhancers: a phase 2b trial for weight loss.
NEJM, 2019 (Buckley ST et al.) - 2
Semaglutide injection (Ozempic) mechanism and GLP-1 receptor agonism.
Lancet, 2021 (Wilding JPH et al.)
Tirzepatide ODTfrom $289/mo