Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Dissolved under the tongue · Once a day
Weight lossOral GLP-1
Semaglutide ODT
Oral semaglutide tablet taken sublingually (under the tongue), designed to mimic the weekly injection. Early-stage evidence; absorption is lower and more variable than injected forms. Physician-guided dosing.
- Mimics the weekly injection in oral form
- Sublingual (under the tongue) for better absorption
- Dosing and adjustment guided by your physician
- Monthly$279/mo
- Every 3 months$747 billed up front$249/mo
- Every 6 monthsBest value$1,314 billed up front$219/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Dissolved under the tongue
- How often
- Once a day
- Each shipment
- 1 bottle
- Strengths
- 6 options · 2–12 mg
What is Semaglutide ODT?
(orally disintegrating tablet, sublingual form)
Semaglutide ODT is a compounded tablet designed to dissolve under the tongue. It mimics the weekly GLP-1 injection but is taken by mouth. Absorption through the oral mucosa is lower and more variable than injected semaglutide; bioavailability data in humans are limited.
What's in it
- SemaglutideGLP-1: quiets appetite, slows digestion
Early-stage
oral formulation; limited human absorption data
Sublingual semaglutide absorbs into the bloodstream via the mouth lining. Absorption is variable between people and lower than injected forms. Your physician will adjust your dose based on your response.
Is it right for you?
Who it's for
People who want semaglutide but will not use a needle.
What sets it apart
It dissolves under the tongue every day instead of one weekly injection, and far less reaches the blood than by injection.
Worth knowing before you start
Take it on an empty stomach and wait 30 minutes before eating or drinking. Skipping that wait is the usual reason it underperforms.
What to expect
Weight loss
pace depends on dose absorption and individual response
Appetite reduction
may appear quickly or gradually
Energy changes
some report early fatigue as eating patterns shift
Close monitoring
frequent check-ins ensure safety given limited data
How oral GLP-1 care works
Day 1
A US-licensed physician reviews your goals, medical history, and medications. Discusses how oral GLP-1 formulations work and the limited human evidence.
1Week 1
Start your first dose sublingually. Keep the tablet or liquid under your tongue as instructed. Appetite may quiet quickly or gradually; effects are unpredictable.
2Weeks 2–4
Your physician checks in to assess how you feel: appetite, digestion, energy, and early weight changes. Dose may be adjusted based on your response.
3Months 2–3
Weight loss builds as your body adjusts. Your physician continues to monitor and refines your dose for optimal effect.
4Beyond
Maintenance dosing continues; your physician decides with you how to hold or adjust your dose over time.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Dissolved under the tongue
- Dose
- 1 tablet (2 mg)
- How often
- Once a day
- Each shipment
- 1 bottle
- Pharmacy label
- Place 1 tablet (2 mg) under the tongue once daily, 30 minutes before food or drink, for 30 days. Let it dissolve; do not chew or swallow it whole.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 2 mg
- 10 mg
- 4 mg
- 12 mg
- 8 mg
- 6 mg
The science of oral GLP-1
Oral semaglutide (traditional tablet with permeation enhancers) exists in clinical trials; sublingual compounded forms lack large human trials. Absorption depends on mouth moisture, contact time, and individual factors.
Many users report appetite reduction and weight loss; effects may take longer to develop than injected forms and require careful dose titration. Your physician monitors response closely.
Learn moreImportant safety information and common side effects
Oral semaglutide and tirzepatide are experimental formulations with limited human data. Common effects include nausea, diarrhea, constipation, and reduced appetite, often in the first weeks as absorption settles. Absorption is variable; blood levels may be unpredictable. Do not use if you or a family member has had medullary thyroid carcinoma or MEN 2. Not for pregnancy or breastfeeding, or with a history of pancreatitis. Tell your physician about all medications, diabetes drugs, and any history of kidney or pancreatic disease. Stop and seek care for severe abdominal pain, signs of pancreatitis, allergic reactions, or vision changes if diabetic.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Semaglutide ODT educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Semaglutide ODT?
Dissolved under the tongue, once a day. The starting prescription is 1 tablet (2 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Semaglutide ODT come in?
The pharmacy carries 6: 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg. Your physician chooses which one you get.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
How does oral semaglutide compare to the injection?
Injected semaglutide has decades of use and higher, more reliable blood levels. Sublingual semaglutide is newer; absorption is unpredictable. Your physician may start at a higher dose to account for variable absorption and adjusts based on how you feel.
Why oral instead of injection?
Oral forms avoid needles. Be aware: absorption is unpredictable and lower than injections, so effects are less reliable. Your physician will adjust your dose frequently as you respond.
What if absorption is poor?
If you see minimal effect after 4–6 weeks at a good dose, your physician may increase the dose, try a different formulation, or recommend switching to injected GLP-1 for better reliability.
How often will I need adjustments?
Frequently at first, every 1–2 weeks in the first month, to find your effective dose. Once stable, check-ins may space out to monthly or every 2 months.
Can I switch between oral and injection?
Yes. If oral doesn't work well or you need more predictable results, your physician can switch you to injected semaglutide or tirzepatide.
Oral GLP-1, experimental option.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Injection
from $129/mo
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Oral semaglutide 2.4 mg once daily with permeation enhancers: a phase 2b trial for weight loss.
NEJM, 2019 (Buckley ST et al.) - 2
Semaglutide injection (Ozempic) mechanism and GLP-1 receptor agonism.
Lancet, 2021 (Wilding JPH et al.)
Semaglutide ODTfrom $219/mo