Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Taken by mouth · Once a day
Weight lossControlledShort-term
Phentermine
Phentermine, a controlled-schedule stimulant approved for short-term weight loss (12 weeks or less). Requires video medical consultation. Works by suppressing appetite and increasing energy. Use only under close physician supervision.
- FDA-approved for short-term weight loss
- Strong appetite suppression
- Video consultation with physician required
- Monthly$129/mo
- Every 3 monthsBest value$327 billed up front$109/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 tablets
- Strength
- 37.5 mg
What is Phentermine?
(sympathomimetic amine, Schedule IV)
Phentermine is an FDA-approved appetite suppressant similar to amphetamine. It stimulates the central nervous system to reduce appetite and increase energy. Approved use is 12 weeks or less. Requires medical screening and ongoing supervision due to cardiovascular and neurological effects.
What's in it
- PhentermineAppetite suppressant (controlled)
Short-term
FDA-approved, 12 weeks maximum
Phentermine is a controlled medication; long-term use risks dependence and cardiovascular issues. Approved only for 12 weeks of continuous use. Your physician will evaluate you with video consultation before prescribing.
Is it right for you?
Who it's for
People who need a short, strong push on appetite and have a healthy heart and blood pressure.
What sets it apart
A stimulant, approved for short-term use, and a controlled substance: it requires a video visit.
Worth knowing before you start
Take it in the morning. Taken after noon, it will keep you awake.
Results you can feel
Rapid weight loss
3–5 kg in 12 weeks (phentermine); up to 10% body weight (combination)
Energy boost
increased alertness and motivation (stimulant effect)
Cardiovascular monitoring
blood pressure and heart rate require close tracking
Psychiatric vigilance
mood, anxiety, and sleep need supervision
How controlled weight-loss therapy works
Day 1
Video consultation with a US-licensed physician. Medical screening: blood pressure, heart rate, ECG may be required. Detailed discussion of risks, benefits, and contraindications. Informed consent required.
1Week 1
Start your dose (low dose for phentermine). Appetite suppression often noticeable within days. Energy increases. Monitor for jitteriness, heart palpitations, or insomnia.
2Weeks 2–4
Weight loss accelerates. Appetite remains suppressed. Your physician checks in weekly or biweekly to monitor cardiovascular and psychological effects.
3Weeks 5–12
Steady, significant weight loss. Physician continues close monitoring. At week 12 (or sooner if phentermine alone), plan for pause or switch to longer-term option.
4Week 12+
Maintenance or transition: if using phentermine alone, pause it (cannot use continuously). Phentermine/topiramate ER may continue if tolerated. Your physician guides next steps.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 tablet (37.5 mg)
- How often
- Once a day
- When
- In the morning
- Each shipment
- 30 tablets
- Pharmacy label
- Take 1 tablet (37.5 mg) by mouth once daily in the morning for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of controlled appetite suppressants
Phentermine produces mean weight loss of 3–5 kg over 12 weeks in clinical trials, greater than placebo. Effects decline after 12 weeks; tolerance develops.
Phentermine is only for people without uncontrolled high blood pressure, heart disease, or certain psychiatric conditions. Your physician must screen you and monitor cardiovascular and psychological effects.
Learn moreImportant safety information and common side effects
Phentermine and phentermine/topiramate are controlled medications with significant risks. Do not use with uncontrolled high blood pressure, heart disease, recent heart attack or stroke, glaucoma, or history of substance abuse. Cardiovascular effects include increased heart rate, elevated blood pressure, and palpitations. Neurological effects include anxiety, insomnia, tremor, and (with topiramate combination) cognitive impairment. Phentermine/topiramate is absolutely teratogenic (causes birth defects); women of childbearing potential must use strict contraception. Tell your physician about all medications, cardiovascular disease, psychiatric conditions, and any history of drug or alcohol abuse. Stop and seek care for chest pain, severe headache, palpitations, shortness of breath, or psychiatric symptoms.
Every plan includes
- Personalized, physician-guided plan
- Monthly and 3-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Phentermine educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Phentermine?
Taken by mouth, once a day, in the morning. The starting prescription is 1 tablet (37.5 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
30 tablets at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Why is phentermine limited to 12 weeks?
Phentermine's effects diminish over time (tolerance), and long-term use increases risks of dependence, hypertension, and cardiovascular issues. 12 weeks is the FDA-approved limit for continuous use. Your physician may pause and restart if appropriate.
Why are these medications controlled?
Phentermine is similar to amphetamine; it stimulates the central nervous system and carries risks of dependence, cardiovascular effects, and psychiatric symptoms. Schedule IV reflects these risks. Strict medical supervision is required.
Can I use phentermine longer than 12 weeks?
Continuous phentermine use is FDA-approved only for 12 weeks or less. After that, tolerance develops and risks increase. Your physician may pause (typically 2–4 weeks) and restart, or switch to the combination (phentermine/topiramate ER, which is approved for longer use).
What if I'm a woman of childbearing age?
Phentermine/topiramate ER is teratogenic (causes birth defects) and absolutely contraindicated in pregnancy. Women of childbearing potential must use highly effective contraception. Phentermine alone is safer in pregnancy, but not recommended. Discuss with your physician.
What happens after 12 weeks?
If using phentermine alone: pause it, then your physician may restart after 2–4 weeks. If using phentermine/topiramate ER: you may continue if tolerated, or transition to a non-controlled option (GLP-1, metformin, etc.) for maintenance.
Potent short-term weight loss, with careful oversight.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
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Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Phentermine efficacy and cardiovascular safety: randomized controlled trials.
Obesity, 2019 - 2
Phentermine/topiramate ER for long-term weight loss (Qsymia): efficacy and safety.
Lancet, 2012 (Gadde KM et al.)
Phenterminefrom $109/mo