Tirzepatide + B12
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with vitamin B12 for energy.
Injection
from $208/mo
Taken by mouth · Once a day
Weight lossOral medicationImmune modulation
Naltrexone Low-Dose
Low-dose naltrexone (LDN) used off-label for weight loss and metabolic support. Naltrexone at low doses may reduce inflammation and appetite signaling, supporting modest weight loss.
- Off-label use for metabolic and appetite support
- May reduce inflammation linked to weight gain
- Gentle daily oral tablet
- Monthly$99/mo
- Every 3 months$237 billed up front$79/mo
- Every 6 monthsBest value$414 billed up front$69/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strengths
- 7 options · 1.5–16 mg
What is Low-Dose Naltrexone?
(LDN, opioid antagonist at low dose)
Naltrexone is approved as a full-dose medication for opioid and alcohol dependence. At low doses (2.5–5 mg daily), it is prescribed off-label for weight loss and metabolic support. The mechanism for weight loss is not fully understood; proposed pathways include reduced inflammation and altered appetite signaling.
What's in it
- NaltrexoneLow dose: appetite and reward signals
Modest
early-stage evidence; mechanism unclear
Low-dose naltrexone is experimental for weight loss. Some users report modest weight loss and improved mood; others see minimal effect. Mechanism is not well-established. Your physician will monitor your response carefully.
Is it right for you?
Who it's for
People whose eating is driven by cravings and reward more than by hunger.
What sets it apart
It acts on the brain's reward signals rather than on digestion. Used off-label and often alongside another treatment.
Worth knowing before you start
It blocks opioid painkillers. Tell every doctor and dentist that you take it before any procedure.
What to expect
Weight loss
steady but modest; depends on diet and activity
Appetite change
reduced hunger or improved fullness is common
Energy and metabolism
gradual improvement with weight loss and diet
Medical oversight
your physician monitors for side effects and efficacy
How oral weight-loss medications work
Day 1
A US-licensed physician reviews your health, metabolism, and why an oral medication may help you. Explains the medication's mechanism and what to expect.
1Week 1–2
Start your dose. You may feel appetite changes within days, or changes may take weeks. GI effects (metformin) or mood changes (naltrexone) are possible early on.
2Weeks 3–6
Your appetite and eating patterns shift. Fullness comes sooner. Your physician checks in and may adjust your dose based on response and tolerability.
3Months 2–3
Steady, gradual weight loss. Metabolism and appetite remain improved. Your physician monitors for any side effects and adjusts dosing.
4Beyond
Maintenance: your physician works with you to hold results or adjust as your body changes. Long-term monitoring ensures ongoing safety.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (1.5 mg)
- How often
- Once a day
- When
- At bedtime
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (1.5 mg) by mouth once daily at bedtime for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 6 mg
- 5 mg
- 1.5 mg
- 8 mg
- 16 mg
- 3 mg
- 4 mg
The science of oral weight-loss medications
Low-dose naltrexone has preclinical and anecdotal support for anti-inflammatory effects and appetite modulation. Human clinical trials for weight loss are limited.
Off-label use is based on mechanism hypothesis and clinical experience. Individual response is highly variable. Your physician explains the limited evidence.
Learn moreImportant safety information and common side effects
Oral weight-loss medications (metformin, naltrexone, topiramate) have different safety profiles. Metformin: GI side effects (nausea, diarrhea) common, especially initially; not for severe kidney disease. Naltrexone: generally well-tolerated; headache or dizziness possible. Topiramate: cognitive effects ('topiramate fog', difficulty concentrating, word-finding) in 10–15%; kidney stones possible. All are off-label for weight loss; efficacy and safety are not FDA-approved for this use. Tell your physician about all medications, kidney disease, and any history of kidney stones (topiramate). Stop and seek care for severe GI pain (metformin), severe headache, allergic reactions, or eye pain (topiramate).
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Low-Dose Naltrexone educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Naltrexone (Low Dose)?
Taken by mouth, once a day, at bedtime. The starting prescription is 1 capsule (1.5 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Naltrexone (Low Dose) come in?
The pharmacy carries 7: 1.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 8 mg, 16 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
How does low-dose naltrexone help with weight loss?
The exact mechanism is not clear. Proposed pathways include reduced inflammation, improved appetite regulation, and changes in reward signaling. The evidence is early. Your physician will assess your response and adjust based on what works for you.
Why are these off-label?
These medications are FDA-approved for other conditions (diabetes, seizures, addiction) but not specifically for weight loss. Off-label use is legal and common; your physician prescribes based on research and experience.
Which one should I choose?
That depends on your health profile, goals, and what side effects you can tolerate. Metformin is gentlest but least effective. Naltrexone is experimental. Topiramate is moderate. Your physician will recommend based on your individual needs.
Can I combine these with GLP-1 drugs?
Yes, some combinations are used; for example, topiramate plus phentermine. However, combining multiple weight-loss medications requires careful physician oversight.
What if these don't work?
If you see minimal effect after 8–12 weeks, your physician may increase the dose, switch medications, or recommend GLP-1 drugs like semaglutide or tirzepatide for stronger effect.
Oral weight loss, gradual and supported.
Semaglutide + B12
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with vitamin B12 for energy.
Injection
from $129/mo
Tirzepatide + Glycine
A weekly dual-action GLP-1/GIP injection for meaningful weight loss and appetite control, paired with glycine for better tolerance.
Injection
from $208/mo
Semaglutide + Glycine
A weekly GLP-1 injection that quiets cravings and supports steady, sustainable weight loss, paired with glycine for better tolerance.
Injection
from $129/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Metformin and weight loss: a systematic review of non-diabetic use.
Obes Surg, 2017 - 2
Topiramate for weight loss: clinical efficacy and safety review.
Drugs Today, 2019
Naltrexone Low-Dosefrom $69/mo