Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Dissolved under the tongue · Once a day
TestosteroneOralCompounded
Testosterone Troches
Compounded testosterone troches (lozenges): dissolved slowly in the mouth, absorbed through oral mucosa. Daily or twice daily dosing, customized compounding. Off-label, mimics steady testosterone.
- Troches (lozenges) dissolve in mouth; absorbed through mucosa
- Daily dosing, customizable strength
- Alternative to injections or topical cream
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Dissolved under the tongue
- How often
- Once a day
- Each shipment
- 30 troches
- Strengths
- 4 options · 10–200 mg
What are testosterone troches?
(TRO-keez)
Testosterone troches are small lozenges containing compounded testosterone. You hold them in your mouth and let them dissolve slowly, 15–30 minutes. The testosterone is absorbed through the oral mucosa (inside of the mouth). Typical dose: 5–25 mg daily or twice daily, customized by compounding pharmacy. Off-label use, popular because it avoids injections and is easier than measuring sublingual liquid.
What's in it
- TestosteroneReplaces low testosterone
Compounded
customizable strength; oral mucosa absorption
Testosterone troches are not FDA-approved; they are compounded to order. Absorption varies based on saliva flow, mouth lesions, and individual anatomy. Your physician adjusts dose based on blood testosterone levels.
Is it right for you?
Who it's for
Men who want testosterone absorbed through the cheek, with many strengths to choose from.
What sets it apart
Four strengths from 10 to 200 mg. Absorbed in the mouth, usually taken twice a day.
Worth knowing before you start
Hold it between cheek and gum and switch sides each time to avoid irritating the gum.
What to expect
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle and strength
testosterone builds lean mass over weeks and months
Lab-monitored safety
hematocrit, PSA, BP tracked at every visit
Close physician oversight
oral therapy requires careful management of absorption and dose
How oral testosterone works
Day 1
US-licensed physician reviews your symptoms, medical history, and testosterone goals. Blood pressure and baseline labs (testosterone, hematocrit, PSA, liver function) are obtained.
1Week 1
Start oral testosterone (Kyzatrex with meals, sublingual, or troches). No needles, no daily patch. Daily or twice-daily dosing provides steady testosterone.
2Week 4
Blood work checks testosterone level. If low, dose is increased. If target is reached, dose is maintained.
3Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, liver function, blood pressure). Symptoms like energy, mood, libido, and erectile function are reviewed.
4Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted as needed to keep testosterone in target range.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Dissolved under the tongue
- Dose
- one troche (10 mg)
- How often
- Once a day
- Each shipment
- 30 troches
- Pharmacy label
- Dissolve one troche (10 mg) under the tongue once daily for 30 days. Do not chew or swallow it whole.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 25 mg
- 75 mg
- 200 mg
- 10 mg
The science of oral testosterone
Troches deliver testosterone via sublingual/buccal absorption (through the rich blood supply of the oral mucosa), bypassing first-pass liver metabolism. This allows effective oral delivery without injections.
Compounded troches offer flexibility in dosing and strength. Your physician works with the pharmacy to customize your dose. Testosterone levels are checked 4–6 weeks after starting to ensure the dose is right.
Learn moreImportant safety information and common side effects
Oral testosterone (Kyzatrex, sublingual, troches) carries the same risks as all testosterone therapy: elevated hematocrit (polycythemia), blood pressure rise, PSA elevation, reduced fertility, and clotting concerns. Kyzatrex is FDA-approved; sublingual and troches are compounded off-label. Blood pressure must be monitored every 3–6 months; hematocrit checked at baseline and every 6–12 months. Liver function tests (AST, ALT) required before and during use. Tell your physician about high blood pressure, blood clotting disorders, heart disease, or PSA concerns. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Testosterone troches educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Testosterone Troches?
Dissolved under the tongue, once a day. The starting prescription is one troche (10 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Testosterone Troches come in?
The pharmacy carries 4: 10 mg, 25 mg, 75 mg, 200 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 troches at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
How do I use testosterone troches?
Place the troche in your mouth between your cheek and gum, or under your tongue. Allow it to dissolve slowly over 15–30 minutes without chewing. Do not swallow pieces; let the mucosa absorb the testosterone. Avoid eating or drinking for 30 minutes before and after. Take at the same time each day.
Which oral testosterone is best, Kyzatrex or troches?
Kyzatrex is FDA-approved and pharmaceutical-grade; sublingual and troches are compounded off-label. Kyzatrex must be taken with meals (essential for absorption). Sublingual and troches offer flexibility and faster adjustments. Your physician chooses based on your preference, absorption, and response.
Will my blood pressure go up on oral testosterone?
Many men see a small rise in blood pressure on testosterone therapy (oral, injection, or topical). Some have no change. Check your BP at baseline and every 3–6 months. If it rises >10 mmHg, your physician may adjust testosterone dose, add a BP medication, or recommend lifestyle changes.
Can I switch from injections to oral testosterone?
Yes. If you have been on injections, your physician can transition you to oral testosterone. Your dose may change because absorption is different. Blood work at 4–6 weeks confirms the dose is right.
Steady testosterone, daily oral dosing.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
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7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
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Anastrozole - Men
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Kyzatrex (testosterone undecanoate) oral formulation: pharmacokinetics and clinical efficacy.
J Clin Endocrinol Metab, 2018 - 2
Sublingual and buccal testosterone delivery: routes of administration for testosterone therapy.
Endocrine Rev, 2018
Testosterone Trochesfrom $99/mo