Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Applied to the skin · Once a day
Men's healthTestosterone therapy
Testosterone Cream (Topi-Click)
Compounded testosterone cream 200 mg/mL in a Topi-Click dispenser for daily application. Steady absorption without needles, typical doses 100–150 mg once daily on shoulders, arms or thighs.
- Applied once daily, no injections needed
- Steady testosterone levels without weekly visits to inject
- Absorbed through skin in about 2 hours, covers waking hours
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strength
- 200 mg/mL
What is topical testosterone cream?
(TES-tos-ter-own KREEM)
Topical testosterone cream is testosterone dissolved in an oil base, dispensed in a metered applicator (Topi-Click) that delivers 50 mg per click. You apply it once daily, usually in the morning, to clean, dry skin on the shoulders, upper arms or inner thighs—never to the genitals. The cream absorbs through the skin over about 2 hours, delivering steady testosterone into your bloodstream throughout the day. One application delivers steady hormone levels without the needle injection that men on weekly or biweekly testosterone therapy experience.
What's in it
- TestosteroneReplaces low testosterone
~2 hours
the absorption window after each morning application: keep the area dry and covered, then it lasts through your day
Avoid washing, swimming or vigorous exercise for 2 hours after application to ensure absorption. Transfer to women and children is possible if skin contact occurs before the site dries.
Is it right for you?
Who it's for
Men who absorb testosterone poorly through the skin and need a concentrated cream.
What sets it apart
The strongest cream: 200 mg per mL, so the amount to spread is small.
Worth knowing before you start
A small amount carries a full dose. One extra click is a real overdose.
Results you can feel
Energy and focus
often the first change men report
Mood and confidence
as testosterone levels stabilize
Strength and recovery
lean muscle support and workout recovery improve
Sexual desire and function
often improve noticeably
How testosterone therapy works
Day 1
A US-licensed physician reviews your symptoms, testosterone level, health history, risk factors and labs (testosterone, hematocrit, PSA, estradiol, lipids), and sets your dose and formulation. Your treatment ships discreetly to your door.
1Weeks 1–4
You begin your chosen formulation (injection, cream, or troche). Energy, mood, and libido often begin to shift. Your physician checks in by messaging.
2Month 2
Lab work (usually testosterone level and hematocrit) is drawn. Your physician reviews your symptoms and adjusts the dose if needed. Most men reach stable levels by month 2–3.
3Month 3
Full check-in. Your physician reviews all labs, how you feel, side effects and whether your dose is right. If acne or mood changes appear, they are usually managed by dose adjustment.
4Ongoing
Testosterone therapy continues as long as it benefits you. Labs (testosterone, hematocrit, PSA, lipids) are checked at least every 6–12 months. Your physician adjusts the dose with you over time.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- skin
- Dose
- 2 clicks (0.5 mL, 100 mg)
- How often
- Once a day
- Each shipment
- 1 tube
- Pharmacy label
- Apply 2 clicks (0.5 mL, 100 mg) to the skin once daily.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of testosterone replacement therapy
Transdermal testosterone delivers physiologic testosterone levels without the peaks and troughs of injections, and is one of the standard options for testosterone replacement therapy in the Endocrine Society guideline.
The Endocrine Society Clinical Practice Guidelines recommend testosterone therapy for men with symptomatic hypogonadism (low testosterone and symptoms), with dose titrated to achieve testosterone levels in the normal range. Topical application offers daily dosing flexibility without injections.
Learn moreImportant safety information and common side effects
Testosterone is a prescription hormone for symptomatic hypogonadism in men without contraindications. Common, usually temporary side effects include acne, oily skin, hair loss (or growth on the body and face), changes in mood or libido, injection-site redness or soreness, and testicular shrinkage (reversible with gonadorelin or hCG). Testosterone increases hematocrit (red blood cell concentration), which can thicken the blood and raise clot risk; your physician monitors this with lab tests and may adjust dose or suggest blood donation if hematocrit rises too high. It can worsen sleep apnea, raise blood pressure slightly, and affect cholesterol levels. Testosterone is not prescribed with a history of prostate or breast cancer, untreated or severe sleep apnea, recent heart attack or stroke, uncontrolled high blood pressure, or abnormally high hematocrit. Testosterone therapy suppresses sperm production (reversible with gonadorelin or hCG if you want to preserve fertility). If you have a partner who could be pregnant, avoid transfer of topical testosterone by washing hands thoroughly and covering the application site. Seek care immediately for chest pain, shortness of breath, unusual leg swelling, severe headache or vision changes. Tell your physician about every medication and supplement you take.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Testosterone cream educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Testosterone Cream (Topi-Click) - Men?
Applied to the skin, once a day. The starting prescription is 2 clicks (0.5 mL, 100 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
How do I apply the testosterone cream?
In the morning, on clean, dry skin of the shoulders, upper arms or inner thighs—never on the genitals. Each click of the Topi-Click dispenser delivers 50 mg, so 2 clicks = 100 mg, 3 clicks = 150 mg. Cover the area lightly and let it dry (about 2 minutes). Avoid washing, swimming or vigorous sweating for 2 hours. Wash your hands after application to reduce transfer risk.
Do I need to take gonadorelin or hCG with testosterone?
Not necessarily. Gonadorelin or hCG are used if you want to preserve sperm production and testicular size while on testosterone therapy. Without them, the testes will shrink slightly and sperm production will stop—effects that reverse if you stop testosterone. Your physician discusses your priorities.
What labs do I need on testosterone therapy?
At baseline and regularly (every 6–12 months): testosterone level, hematocrit (to check for polycythemia), PSA (to screen for prostate concerns), estradiol (some testosterone converts to estrogen), and lipids (cholesterol and triglycerides). Your physician explains what the results mean and adjusts your dose based on them.
Can I stop testosterone therapy anytime?
Yes. Testosterone therapy is not a lifetime commitment; you can pause or stop. If you stop suddenly, testosterone levels will fall over days to weeks (depending on formulation) and you may feel the original hypogonadism symptoms return. Your physician helps you taper if you choose, and many men simply stop and restart later if they need to.
Hormones, balanced.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
from $159/mo
7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
from $79/mo
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
J Clin Endocrinol Metab, 2018 - 2
Cardiovascular Safety of Testosterone-Replacement Therapy (TRAVERSE).
N Engl J Med, 2023 - 3
Pharmacology of testosterone replacement therapy preparations.
Transl Androl Urol, 2016 - 4
New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men.
J Clin Endocrinol Metab, 2004
Testosterone Cream (Topi-Click)from $99/mo