Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Applied to the skin · Once a day
Low-dose testosteroneWomen's health
Testosterone Cream for Women
Low-dose testosterone cream for women: 0.5–2 mg daily applied to skin, enhances sexual interest, mood, and energy. Off-label use; requires estradiol monitoring for safety.
- Low dose (0.5–2 mg), tailored for women's physiology
- Enhances sexual interest, mood, and energy
- Topical application once daily, easy to adjust dose
- Monthly$109/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strengths
- 3 options · 2 clicks, 2 mg
What is low-dose testosterone cream for women?
(lo-dose tes-TOS-ter-own for WU-men)
Low-dose testosterone cream for women is testosterone in a compounded topical cream, typically 0.5–2 mg daily. Applied to skin (usually inner arm or thigh), it is absorbed over 2 hours. Used off-label, it enhances sexual interest, improves mood and energy, and supports muscle tone. Because women's bodies are sensitive to testosterone, doses are far lower than for men, and estradiol levels must be monitored.
What's in it
- TestosteroneReplaces low testosterone
0.5–2 mg daily
low dose customized for women; requires estradiol monitoring
Women on testosterone must be monitored for estradiol levels (to avoid elevated conversion) and for virilization (voice deepening, facial hair), though these are rare at low doses. Benefits often appear within 2–4 weeks.
Is it right for you?
Who it's for
Women after menopause with low desire that distresses them.
What sets it apart
A dose made for women, about a tenth of a man's. No testosterone product is FDA-approved for women.
Worth knowing before you start
Voice changes and clitoral enlargement can be permanent. Report hoarseness right away.
What to expect
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle
lean mass gains over 4–12 weeks
Lab-monitored
hematocrit, PSA, BP tracked regularly
Careful transfer prevention
wash hands, cover area, avoid skin-to-skin contact for 2 hours
How topical testosterone works
Day 1
US-licensed physician reviews testosterone goals, medical history, and baseline labs (testosterone, hematocrit, PSA, liver function, BP).
1Week 1
Start topical testosterone (cream, hydrogel, or low-dose for women). Apply once daily to clean, dry skin. No injections or pills.
2Week 4
Blood work checks testosterone level. If below target, dose is increased. If target is reached, dose is maintained.
3Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, BP). Symptoms (energy, libido, mood, erectile function) reviewed.
4Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted to keep testosterone in target range.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- inner forearm
- Dose
- 0.5 mL (2 clicks, 2 mg)
- How often
- Once a day
- Each shipment
- 1 tube
- Pharmacy label
- Apply 0.5 mL (2 clicks, 2 mg) to the inner forearm once daily for 30 days. Wash hands after use.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 4 mg/mL
- 2 mg/mL
- 1 mg/mL
The science of topical testosterone
Low-dose testosterone in women enhances libido and sexual satisfaction, improves mood, and supports lean muscle. Women metabolize testosterone differently than men due to hormonal context; lower doses are used.
Off-label testosterone for women is gaining clinical acceptance for hypoactive sexual desire disorder (HSDD) and low energy. Your physician monitors estradiol and symptoms closely.
Learn moreImportant safety information and common side effects
Topical testosterone (creams, hydrogels) carries the same safety considerations as all testosterone therapy: elevated hematocrit, blood pressure rise, PSA elevation, and reduced fertility during active therapy. Transfer to others (especially women and children) is possible before the application site dries. Wash hands thoroughly after application and cover the area. For women on low-dose testosterone, virilization is rare at doses <2 mg daily but must be monitored. Tell your physician about high blood pressure, blood clotting, PSA concerns, or plans to father children. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
Every plan includes
- Personalized, physician-guided plan
- Monthly plan
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Testosterone cream (women) educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Testosterone Cream for Women (Topi-Click)?
Applied to the skin, once a day. The starting prescription is 0.5 mL (2 clicks, 2 mg) each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Inner forearm.
What strengths does Testosterone Cream for Women (Topi-Click) come in?
The pharmacy carries 3: 4 mg/mL, 2 mg/mL, 1 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Will testosterone cream make me look more masculine?
At low doses (0.5–2 mg daily), virilization (masculine features like deepened voice, facial hair) is very rare. The dose is tailored to enhance sexual interest and energy without crossing into masculinizing effects. Your physician monitors you closely and adjusts dose if any virilization signs appear.
Will topical testosterone transfer to my partner?
Transfer is possible if skin-to-skin contact occurs before the application site dries (within 2 hours). Wash your hands thoroughly after application, cover the area with clothing, and avoid skin contact. After 2 hours, the risk is minimal.
What if I forget a dose?
If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose. Do not apply extra testosterone to make up for a missed dose. Inconsistent dosing can cause fluctuations in testosterone levels.
Testosterone without injections or pills.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
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7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
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Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Transdermal testosterone delivery in men: a review of pharmacokinetics and clinical outcomes.
Endocrine Rev, 2018 - 2
Topical testosterone for women: low-dose efficacy and safety in sexual desire and energy.
Maturitas, 2017
Testosterone Cream for Womenfrom $109/mo