Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Applied to the skin · Once a day
TestosteroneTopicalNo injections
Testosterone Cream (Topi-Click)
Compounded testosterone cream 200 mg/mL in Topi-Click dispenser for men: apply once daily to shoulders or arms. Steady absorption, no needles, typical dose 100–150 mg daily.
- Applied once daily, steady levels without weekly injections
- Absorbed through skin over 2 hours, lasts all day
- Topi-Click dispenser is convenient and consistent (50 mg per click)
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strengths
- 7 options · 4 clicks, 30 mg
What is topical testosterone cream for men?
(TO-pik-al tes-TOS-ter-own)
Topical testosterone cream is testosterone dissolved in an oil or emulsion base, applied to the skin once daily. The Topi-Click dispenser delivers 50 mg per click, so 2–3 clicks provides 100–150 mg. Applied to clean, dry skin on the shoulders, upper arms, or inner thighs (never genitals), the cream is absorbed through the skin over about 2 hours, providing steady testosterone throughout the day. Compounded to order, allowing customization of strength.
What's in it
- TestosteroneReplaces low testosterone
2-hour absorption
steady levels all day after morning application
Transfer to women and children is possible if skin contact occurs before the site dries. Keep area covered and ensure skin is dry after application. Avoid vigorous exercise or swimming for 2 hours.
Is it right for you?
Who it's for
Men who want testosterone through the skin with a dose that can be fine-tuned.
What sets it apart
Seven strengths, from 10 to 120 mg per mL: the widest range of any form here.
Worth knowing before you start
Blood is drawn before the morning dose, not after, or the result reads falsely high.
What to expect
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle
lean mass gains over 4–12 weeks
Lab-monitored
hematocrit, PSA, BP tracked regularly
Careful transfer prevention
wash hands, cover area, avoid skin-to-skin contact for 2 hours
How topical testosterone works
Day 1
US-licensed physician reviews testosterone goals, medical history, and baseline labs (testosterone, hematocrit, PSA, liver function, BP).
1Week 1
Start topical testosterone (cream, hydrogel, or low-dose for women). Apply once daily to clean, dry skin. No injections or pills.
2Week 4
Blood work checks testosterone level. If below target, dose is increased. If target is reached, dose is maintained.
3Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, BP). Symptoms (energy, libido, mood, erectile function) reviewed.
4Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted to keep testosterone in target range.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- shoulders or upper arms
- Dose
- 1 mL (4 clicks, 30 mg)
- How often
- Once a day
- When
- In the morning
- Each shipment
- 1 tube
- Pharmacy label
- Apply 1 mL (4 clicks, 30 mg) to the shoulders or upper arms once daily in the morning for 30 days. Wash hands after use and cover the area.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 30 mg/mL
- 120 mg/mL
- 40 mg/mL
- 10 mg/mL
- 50 mg/mL
- 100 mg/mL
- 20 mg/mL
The science of topical testosterone
Transdermal testosterone delivery via cream avoids the peaks and troughs of injections, maintaining steady physiologic testosterone levels throughout the day.
Topical testosterone is one of the Endocrine Society's recommended options for testosterone replacement therapy, offering flexibility and steady dosing without needles.
Learn moreImportant safety information and common side effects
Topical testosterone (creams, hydrogels) carries the same safety considerations as all testosterone therapy: elevated hematocrit, blood pressure rise, PSA elevation, and reduced fertility during active therapy. Transfer to others (especially women and children) is possible before the application site dries. Wash hands thoroughly after application and cover the area. For women on low-dose testosterone, virilization is rare at doses <2 mg daily but must be monitored. Tell your physician about high blood pressure, blood clotting, PSA concerns, or plans to father children. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Testosterone cream (men) educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Testosterone Cream (Topi-Click)?
Applied to the skin, once a day, in the morning. The starting prescription is 1 mL (4 clicks, 30 mg) each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Shoulders or upper arms.
What strengths does Testosterone Cream (Topi-Click) come in?
The pharmacy carries 7: 30 mg/mL, 120 mg/mL, 40 mg/mL, 10 mg/mL, 50 mg/mL, 100 mg/mL, 20 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
How do I apply testosterone cream?
In the morning, on clean, dry skin of the shoulders, upper arms, or inner thighs. Each Topi-Click dispenser click delivers 50 mg. So 2 clicks = 100 mg, 3 clicks = 150 mg. Rub in gently and cover lightly. Wash hands after application. Avoid washing the area or vigorous exercise for 2 hours to ensure absorption.
Will topical testosterone transfer to my partner?
Transfer is possible if skin-to-skin contact occurs before the application site dries (within 2 hours). Wash your hands thoroughly after application, cover the area with clothing, and avoid skin contact. After 2 hours, the risk is minimal.
What if I forget a dose?
If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose. Do not apply extra testosterone to make up for a missed dose. Inconsistent dosing can cause fluctuations in testosterone levels.
Testosterone without injections or pills.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
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7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
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Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Transdermal testosterone delivery in men: a review of pharmacokinetics and clinical outcomes.
Endocrine Rev, 2018 - 2
Topical testosterone for women: low-dose efficacy and safety in sexual desire and energy.
Maturitas, 2017
Testosterone Cream (Topi-Click)from $99/mo