Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Injected into the muscle · Once a week
Men's healthTestosterone therapy
Testosterone Blend (Cyp/Enan/Prop)
Three-ester blend (cypionate 100 mg/mL, enanthate 100 mg/mL, propionate 50 mg/mL) for once-weekly injection. Propionate acts quickly but can sting at the injection site; fast, intermediate and long-acting components.
- One injection weekly covers fast, intermediate and long-acting coverage
- Propionate gives rapid initial rise, longer esters provide stability
- Suitable for men who prefer the benefit of mixed-ester timing
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Injected into the muscle
- How often
- Once a week
- Each shipment
- 1 vial
- Strength
- 100 mg / 100 mg / 50 mg/mL
What is a testosterone ester blend?
(TES-tos-ter-own ES-ter BLEND)
A testosterone ester blend mixes three esters with different release speeds: propionate (fast, acting in days), enanthate (intermediate, ~8 days), and cypionate (long, ~7 days). Propionate reaches your bloodstream quickly, creating a rapid rise; the longer esters provide continuity as the week passes. This mix is designed for men who want all three timing profiles in a single weekly injection. Propionate can sting more at the injection site than longer esters, which is why some men choose one long-acting ester only. Your physician helps you decide which formulation suits you.
What's in it
- Testosterone CypionateReplaces low testosterone
- EnanthateReplaces low testosterone
- PropionateReplaces low testosterone
3 esters
fast, intermediate and long-acting components in one blend
Propionate is short-acting and can cause injection-site discomfort in some men. If irritation happens, tell your physician; a single long-acting ester may be better tolerated.
Is it right for you?
Who it's for
Men who want a fast-acting and a long-acting testosterone in the same injection.
What sets it apart
Three esters in one vial: propionate acts in a day, cypionate and enanthate carry the week.
Worth knowing before you start
A blend is harder to adjust than a single ester. It is not a stronger testosterone.
Results you can feel
Energy and focus
often the first change men report
Mood and confidence
as testosterone levels stabilize
Strength and recovery
lean muscle support and workout recovery improve
Sexual desire and function
often improve noticeably
How testosterone therapy works
Day 1
A US-licensed physician reviews your symptoms, testosterone level, health history, risk factors and labs (testosterone, hematocrit, PSA, estradiol, lipids), and sets your dose and formulation. Your treatment ships discreetly to your door.
1Weeks 1–4
You begin your chosen formulation (injection, cream, or troche). Energy, mood, and libido often begin to shift. Your physician checks in by messaging.
2Month 2
Lab work (usually testosterone level and hematocrit) is drawn. Your physician reviews your symptoms and adjusts the dose if needed. Most men reach stable levels by month 2–3.
3Month 3
Full check-in. Your physician reviews all labs, how you feel, side effects and whether your dose is right. If acne or mood changes appear, they are usually managed by dose adjustment.
4Ongoing
Testosterone therapy continues as long as it benefits you. Labs (testosterone, hematocrit, PSA, lipids) are checked at least every 6–12 months. Your physician adjusts the dose with you over time.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Injected into the muscle
- Dose
- 0.4 mL (100 mg total testosterone)
- How often
- Once a week
- Each shipment
- 1 vial
- Pharmacy label
- Inject 0.4 mL (100 mg total testosterone) intramuscularly once weekly.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a week
The science of testosterone replacement therapy
Mixed-ester testosterone formulations offer a rationale combining rapid onset from propionate and sustained levels from longer esters. Clinical use shows that some men prefer the steady rise and fall over a week, while others find single esters sufficient.
The choice among testosterone formulations—single esters, blends, or daily topical—is based on your lifestyle, needle comfort, preferred injection frequency and individual response. Your physician tailors it to you.
Learn moreImportant safety information and common side effects
Testosterone is a prescription hormone for symptomatic hypogonadism in men without contraindications. Common, usually temporary side effects include acne, oily skin, hair loss (or growth on the body and face), changes in mood or libido, injection-site redness or soreness, and testicular shrinkage (reversible with gonadorelin or hCG). Testosterone increases hematocrit (red blood cell concentration), which can thicken the blood and raise clot risk; your physician monitors this with lab tests and may adjust dose or suggest blood donation if hematocrit rises too high. It can worsen sleep apnea, raise blood pressure slightly, and affect cholesterol levels. Testosterone is not prescribed with a history of prostate or breast cancer, untreated or severe sleep apnea, recent heart attack or stroke, uncontrolled high blood pressure, or abnormally high hematocrit. Testosterone therapy suppresses sperm production (reversible with gonadorelin or hCG if you want to preserve fertility). If you have a partner who could be pregnant, avoid transfer of topical testosterone by washing hands thoroughly and covering the application site. Seek care immediately for chest pain, shortness of breath, unusual leg swelling, severe headache or vision changes. Tell your physician about every medication and supplement you take.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Testosterone blend educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Testosterone Cypionate / Enanthate / Propionate - Men?
Injected into the muscle, once a week. The starting prescription is 0.4 mL (100 mg total testosterone) each time. Your physician sets your own dose and it is printed on your label.
What exactly is in it?
Testosterone Cypionate, Enanthate, Propionate.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Why would I choose a blend over a single ester?
Some men prefer the faster initial rise from propionate combined with the stability of longer esters over a week. Others find it more complex than needed and prefer a single ester. It's a matter of preference and what your body responds to. If you try it and prefer different timing, your physician can switch you.
Do I need to take gonadorelin or hCG with testosterone?
Not necessarily. Gonadorelin or hCG are used if you want to preserve sperm production and testicular size while on testosterone therapy. Without them, the testes will shrink slightly and sperm production will stop—effects that reverse if you stop testosterone. Your physician discusses your priorities.
What labs do I need on testosterone therapy?
At baseline and regularly (every 6–12 months): testosterone level, hematocrit (to check for polycythemia), PSA (to screen for prostate concerns), estradiol (some testosterone converts to estrogen), and lipids (cholesterol and triglycerides). Your physician explains what the results mean and adjusts your dose based on them.
Can I stop testosterone therapy anytime?
Yes. Testosterone therapy is not a lifetime commitment; you can pause or stop. If you stop suddenly, testosterone levels will fall over days to weeks (depending on formulation) and you may feel the original hypogonadism symptoms return. Your physician helps you taper if you choose, and many men simply stop and restart later if they need to.
Hormones, balanced.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
from $159/mo
7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
from $79/mo
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
J Clin Endocrinol Metab, 2018 - 2
Cardiovascular Safety of Testosterone-Replacement Therapy (TRAVERSE).
N Engl J Med, 2023 - 3
Pharmacology of testosterone replacement therapy preparations.
Transl Androl Urol, 2016 - 4
New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men.
J Clin Endocrinol Metab, 2004
Testosterone Blend (Cyp/Enan/Prop)from $99/mo