Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Applied to the skin · Once a day
TestosteroneHydrogelTopical
Testosterone Atrevis Hydrogel
Atrevis (testosterone hydrogel, commercial brand): fast-absorbing hydrogel formulation, applied once daily. Provides steady testosterone without the oiliness of cream.
- Hydrogel absorbs faster than traditional creams, cleaner feel
- Once-daily application, steady levels
- Commercial pharmaceutical-grade formulation
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strength
- 100 mg/mL
What is Atrevis hydrogel?
(ah-TREV-is)
Atrevis is a commercial pharmaceutical-grade testosterone hydrogel formulation. Hydrogels are water-based and absorb into skin faster and cleaner than oil-based creams, without leaving a greasy residue. Applied once daily, typical dose 50–100 mg, Atrevis delivers steady testosterone levels. It is less commonly used than cream but preferred by some men for comfort and cosmetic reasons.
What's in it
- TestosteroneReplaces low testosterone
Hydrogel base
water-based, faster absorption, clean feel
Atrevis is a commercial brand, offering consistent pharmaceutical-grade testosterone. It provides the same steady delivery as cream but with a cleaner, less oily feel. Transfer risk is lower due to hydrogel base.
Is it right for you?
Who it's for
Men who want a daily testosterone gel that dries fast and does not feel greasy.
What sets it apart
A hydrogel base instead of a cream, in a dial-a-dose applicator.
Worth knowing before you start
Let it dry before dressing, and keep treated skin away from children and partners.
What to expect
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle
lean mass gains over 4–12 weeks
Lab-monitored
hematocrit, PSA, BP tracked regularly
Careful transfer prevention
wash hands, cover area, avoid skin-to-skin contact for 2 hours
How topical testosterone works
Day 1
US-licensed physician reviews testosterone goals, medical history, and baseline labs (testosterone, hematocrit, PSA, liver function, BP).
1Week 1
Start topical testosterone (cream, hydrogel, or low-dose for women). Apply once daily to clean, dry skin. No injections or pills.
2Week 4
Blood work checks testosterone level. If below target, dose is increased. If target is reached, dose is maintained.
3Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, BP). Symptoms (energy, libido, mood, erectile function) reviewed.
4Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted to keep testosterone in target range.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- shoulders or upper arms
- Dose
- 1 mL (4 clicks, 100 mg)
- How often
- Once a day
- When
- In the morning
- Each shipment
- 1 tube
- Pharmacy label
- Apply 1 mL (4 clicks, 100 mg) to the shoulders or upper arms once daily in the morning for 30 days. Wash hands after use and cover the area.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of topical testosterone
Hydrogel-based testosterone delivers steady transdermal absorption like cream but with a hydrophilic (water-loving) base that evaporates or absorbs cleanly without leaving an oily layer.
Atrevis is an alternative to traditional testosterone cream for men who prefer a lighter feel or live in warm climates where cream feels uncomfortable.
Learn moreImportant safety information and common side effects
Topical testosterone (creams, hydrogels) carries the same safety considerations as all testosterone therapy: elevated hematocrit, blood pressure rise, PSA elevation, and reduced fertility during active therapy. Transfer to others (especially women and children) is possible before the application site dries. Wash hands thoroughly after application and cover the area. For women on low-dose testosterone, virilization is rare at doses <2 mg daily but must be monitored. Tell your physician about high blood pressure, blood clotting, PSA concerns, or plans to father children. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Atrevis hydrogel educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Testosterone Atrevis Hydrogel (Topi-Click)?
Applied to the skin, once a day, in the morning. The starting prescription is 1 mL (4 clicks, 100 mg) each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Shoulders or upper arms.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
How is Atrevis different from regular testosterone cream?
Atrevis is a hydrogel (water-based); regular creams are oil-based. Hydrogels absorb faster, feel less greasy, and are less likely to transfer to others. Both deliver steady testosterone, but Atrevis is preferred by men who find oil-based cream uncomfortable or too heavy.
Will topical testosterone transfer to my partner?
Transfer is possible if skin-to-skin contact occurs before the application site dries (within 2 hours). Wash your hands thoroughly after application, cover the area with clothing, and avoid skin contact. After 2 hours, the risk is minimal.
What if I forget a dose?
If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose. Do not apply extra testosterone to make up for a missed dose. Inconsistent dosing can cause fluctuations in testosterone levels.
Can I use topical testosterone with other medications?
Most medications do not interact with topical testosterone, but tell your physician about blood thinners, blood pressure medications, and any other drugs. Some interactions are possible but can be managed.
Testosterone without injections or pills.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
from $159/mo
7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
from $79/mo
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Transdermal testosterone delivery in men: a review of pharmacokinetics and clinical outcomes.
Endocrine Rev, 2018 - 2
Topical testosterone for women: low-dose efficacy and safety in sexual desire and energy.
Maturitas, 2017
Testosterone Atrevis Hydrogelfrom $99/mo