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Dissolved under the tongue · Once a day
BioidenticalOral dissolvingUterine protection
Progesterone ODT
Bioidentical micronized progesterone as orally dissolving tablets for uterine protection. One tablet daily under the tongue, usually at bedtime.
- Bioidentical micronized progesterone
- Dissolves under the tongue
- Convenient uterine protection
- Monthly$99/mo
- Every 3 months$237 billed up front$79/mo
- Every 6 monthsBest value$414 billed up front$69/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Dissolved under the tongue
- How often
- Once a day
- Each shipment
- 30 tablets
- Strength
- 150 mg - Raspberry
What is progesterone ODT?
(orally dissolving tablet, bioidentical micronized progesterone)
Progesterone ODT delivers micronized progesterone as a small tablet that dissolves under your tongue, providing sublingual absorption. Convenient, no pills to swallow. Micronized progesterone has better absorption than older synthetic forms and was used in the WHI and KEEPS trials.
What's in it
- ProgesteroneProtects the uterus; helps sleep
Sublingual
bioidentical micronized progesterone, orally dissolving
One tablet (100-200 mg) daily, usually in the evening under the tongue. Allow 1-2 minutes to dissolve completely.
Is it right for you?
Who it's for
Women who get too drowsy or dizzy from the capsule.
What sets it apart
Dissolves in the mouth, so less of it becomes the sedating by-products the liver makes.
Worth knowing before you start
Raspberry flavor. Let it dissolve; do not swallow it whole.
Protection you don't feel
Endometrial protection
progesterone prevents cancer from unopposed estrogen
Hormone balance
progesterone completes the estrogen-progesterone partnership
Sleep support
many patients report improved sleep with evening progesterone
Continued estrogen benefit
estrogen-progesterone together is safe with a uterus
How progesterone therapy works
Day 1
A US-licensed physician explains why progesterone is mandatory if you have a uterus and use estrogen.
1Week 1
Start your progesterone dose at the prescribed strength. Evening dosing helps you sleep through any drowsiness.
2Weeks 2-4
You may notice mild drowsiness or mood changes. Most effects settle within 2-4 weeks. Your physician monitors these effects.
3Month 3
Check-in. Your physician confirms that progesterone is working as expected and reviews any side effects.
4Beyond
Continue progesterone as long as you use estrogen and have a uterus. Your physician reassesses yearly.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Dissolved under the tongue
- Dose
- one tablet (150 mg)
- How often
- Once a day
- When
- At bedtime
- Each shipment
- 30 tablets
- Pharmacy label
- Place one tablet (150 mg) under the tongue at bedtime once daily for 30 days. Do not chew or swallow it whole.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of progesterone protection
Sublingual absorption avoids first-pass liver metabolism, potentially providing more consistent blood levels than swallowed progesterone.
Progesterone may cause drowsiness, so evening dosing is recommended. Some patients experience mild mood changes. Your physician monitors these effects.
Learn moreImportant safety information and common side effects
Progesterone is essential for uterine protection when using estrogen therapy. Common effects include drowsiness (especially if taken in the evening), mood changes, bloating, and breast tenderness. Progesterone does not increase blood clot or stroke risk significantly (unlike estrogen). Rare effects include dizziness or headache. Tell your physician if you experience severe mood changes, severe bloating, or persistent headache. Progesterone is not prescribed during pregnancy (it is already high). Stop and seek care for severe allergic symptoms.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Progesterone ODT educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Progesterone ODT?
Dissolved under the tongue, once a day, at bedtime. The starting prescription is one tablet (150 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
30 tablets at the starting strength, shipped to your door from a licensed US pharmacy.
How do I use progesterone ODT?
Place one tablet under your tongue, usually in the evening. Allow it to dissolve completely without chewing or swallowing whole. Dissolution takes 1-2 minutes. Do not eat or drink for 15 minutes after taking to allow full absorption.
Can I skip progesterone if my symptoms improve on estrogen alone?
No. Progesterone is mandatory with estrogen if you have a uterus. The protection is about cancer prevention, not symptom relief. Stopping progesterone while using estrogen significantly raises endometrial cancer risk. Your physician does not recommend this.
Does progesterone cause weight gain?
Some patients report mild bloating or water retention, but true weight gain is uncommon. If you notice significant weight gain, tell your physician. You may adjust dose, timing, or form.
Why do I take progesterone in the evening?
Progesterone causes drowsiness in many patients. Evening dosing helps you sleep and avoids daytime sedation. However, if you experience drowsiness, tell your physician, they may adjust timing or dose.
Progesterone, the uterine guardian.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
WHI Steering Committee: Risks and benefits of estrogen plus progestin in healthy postmenopausal women.
JAMA, 2002 - 2
KEEPS Investigators: The Kronos Early Estrogen Prevention Study (KEEPS).
Menopause, 2016
Progesterone ODTfrom $69/mo