Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Applied to the skin · Once a day
BioidenticalTopicalUterine protection
Progesterone Cream
Bioidentical micronized progesterone as a topical cream for uterine protection. Apply daily to skin. Flexible dosing, gentle absorption.
- Bioidentical micronized progesterone
- Topical application
- Adjustable dosing
- Monthly$109/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strengths
- 3 options · 4 clicks, 50 mg
What is progesterone cream?
(bioidentical progesterone, topical)
Progesterone cream delivers micronized progesterone through the skin for systemic absorption. Topical application avoids first-pass liver metabolism and allows flexible dosing. If you have a uterus and use estrogen, progesterone cream provides uterine protection. Apply daily to clean, dry skin.
What's in it
- ProgesteroneProtects the uterus; helps sleep
Topical
bioidentical micronized progesterone, applied to skin
Apply 20-40 mg daily (0.25-0.5 mL), usually in the evening. Your physician adjusts based on symptom control and blood work.
Is it right for you?
Who it's for
Women who cannot take progesterone by mouth.
What sets it apart
Through the skin, blood levels are low and may not protect the uterus.
Worth knowing before you start
If you take estrogen and have a uterus, your physician will usually prefer the capsule.
Protection you don't feel
Endometrial protection
progesterone prevents cancer from unopposed estrogen
Hormone balance
progesterone completes the estrogen-progesterone partnership
Sleep support
many patients report improved sleep with evening progesterone
Continued estrogen benefit
estrogen-progesterone together is safe with a uterus
How progesterone therapy works
Day 1
A US-licensed physician explains why progesterone is mandatory if you have a uterus and use estrogen.
1Week 1
Start your progesterone dose at the prescribed strength. Evening dosing helps you sleep through any drowsiness.
2Weeks 2-4
You may notice mild drowsiness or mood changes. Most effects settle within 2-4 weeks. Your physician monitors these effects.
3Month 3
Check-in. Your physician confirms that progesterone is working as expected and reviews any side effects.
4Beyond
Continue progesterone as long as you use estrogen and have a uterus. Your physician reassesses yearly.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- inner forearm or inner thigh
- Dose
- 1 mL (4 clicks, 50 mg)
- How often
- Once a day
- Each shipment
- 1 tube
- Pharmacy label
- Apply 1 mL (4 clicks, 50 mg) to the inner forearm or inner thigh once daily for 30 days. Rotate sites and wash hands after use.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 50 mg/mL
- 100 mg/mL
- 200 mg/mL
The science of progesterone protection
Transdermal progesterone delivery has variable absorption and blood levels. Your physician may check progesterone levels to confirm you are achieving therapeutic exposure.
Progesterone may cause drowsiness, mild mood changes, or breast tenderness. Evening application helps manage drowsiness. Your physician monitors these effects.
Learn moreImportant safety information and common side effects
Progesterone is essential for uterine protection when using estrogen therapy. Common effects include drowsiness (especially if taken in the evening), mood changes, bloating, and breast tenderness. Progesterone does not increase blood clot or stroke risk significantly (unlike estrogen). Rare effects include dizziness or headache. Tell your physician if you experience severe mood changes, severe bloating, or persistent headache. Progesterone is not prescribed during pregnancy (it is already high). Stop and seek care for severe allergic symptoms.
Every plan includes
- Personalized, physician-guided plan
- Monthly plan
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Progesterone cream educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Progesterone Cream?
Applied to the skin, once a day. The starting prescription is 1 mL (4 clicks, 50 mg) each time. Your physician sets your own dose and it is printed on your label.
Where do I apply it?
Inner forearm or inner thigh.
What strengths does Progesterone Cream come in?
The pharmacy carries 3: 50 mg/mL, 100 mg/mL, 200 mg/mL. Your physician chooses which one you get.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
How much progesterone cream should I apply?
Your physician sets your dose, usually 20-40 mg daily (0.25-0.5 mL), applied to clean, dry skin. Use a metered applicator. Apply to areas like your forearm, chest, or inner thigh, where skin is thin and absorption is good. Rotate application sites to avoid skin irritation.
Can I skip progesterone if my symptoms improve on estrogen alone?
No. Progesterone is mandatory with estrogen if you have a uterus. The protection is about cancer prevention, not symptom relief. Stopping progesterone while using estrogen significantly raises endometrial cancer risk. Your physician does not recommend this.
Does progesterone cause weight gain?
Some patients report mild bloating or water retention, but true weight gain is uncommon. If you notice significant weight gain, tell your physician. You may adjust dose, timing, or form.
Why do I take progesterone in the evening?
Progesterone causes drowsiness in many patients. Evening dosing helps you sleep and avoids daytime sedation. However, if you experience drowsiness, tell your physician, they may adjust timing or dose.
Progesterone, the uterine guardian.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
WHI Steering Committee: Risks and benefits of estrogen plus progestin in healthy postmenopausal women.
JAMA, 2002 - 2
KEEPS Investigators: The Kronos Early Estrogen Prevention Study (KEEPS).
Menopause, 2016
Progesterone Creamfrom $109/mo