Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Taken by mouth · Once a day
BioidenticalUterine protectionMicronized
Progesterone Capsules (Micronized)
Bioidentical micronized progesterone for uterine protection with estrogen therapy. Take once or twice daily. Essential if you have a uterus.
- Bioidentical micronized progesterone
- Protects uterine lining
- Well-studied in KEEPS and WHI trials
- Monthly$99/mo
- Every 3 months$237 billed up front$79/mo
- Every 6 monthsBest value$414 billed up front$69/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strengths
- 8 options · 50–300 mg
What is progesterone?
(micronized progesterone, bioidentical)
Progesterone is the hormone your ovaries made to maintain pregnancy and regulate your cycle. In menopause, when paired with estrogen therapy, progesterone protects the uterine lining (endometrium) from overgrowth and endometrial cancer. Micronized progesterone is finely ground to improve absorption. The WHI and KEEPS trials used micronized progesterone and showed that combined hormone therapy reduced breast and endometrial cancer risk.
What's in it
- ProgesteroneProtects the uterus; helps sleep
Obligatory
with estrogen if you have a uterus, to prevent endometrial cancer
Take 100-300 mg daily (usually in one or two doses), as prescribed. Evening dosing helps manage any drowsiness.
Is it right for you?
Who it's for
Women on estrogen who have a uterus, or women with poor sleep around menopause.
What sets it apart
The same micronized progesterone as the FDA-approved capsule, in eight strengths.
Worth knowing before you start
Take it at bedtime. The drowsiness is the point.
Protection you don't feel
Endometrial protection
progesterone prevents cancer from unopposed estrogen
Hormone balance
progesterone completes the estrogen-progesterone partnership
Sleep support
many patients report improved sleep with evening progesterone
Continued estrogen benefit
estrogen-progesterone together is safe with a uterus
How progesterone therapy works
Day 1
A US-licensed physician explains why progesterone is mandatory if you have a uterus and use estrogen.
1Week 1
Start your progesterone dose at the prescribed strength. Evening dosing helps you sleep through any drowsiness.
2Weeks 2-4
You may notice mild drowsiness or mood changes. Most effects settle within 2-4 weeks. Your physician monitors these effects.
3Month 3
Check-in. Your physician confirms that progesterone is working as expected and reviews any side effects.
4Beyond
Continue progesterone as long as you use estrogen and have a uterus. Your physician reassesses yearly.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (50 mg)
- How often
- Once a day
- When
- At bedtime
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (50 mg) by mouth once daily at bedtime for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 250 mg
- 50 mg
- 200 mg
- 75 mg
- 100 mg
- 150 mg
- 300 mg
- 175 mg
The science of progesterone protection
The WHI trial found that unopposed estrogen (without progesterone) in women with a uterus increased endometrial cancer risk 2-3 fold. Adding micronized progesterone eliminated this excess risk.
Progesterone may cause drowsiness, mood changes, or bloating. These effects often diminish with time. Your physician monitors tolerability and may adjust timing or dose.
Learn moreImportant safety information and common side effects
Progesterone is essential for uterine protection when using estrogen therapy. Common effects include drowsiness (especially if taken in the evening), mood changes, bloating, and breast tenderness. Progesterone does not increase blood clot or stroke risk significantly (unlike estrogen). Rare effects include dizziness or headache. Tell your physician if you experience severe mood changes, severe bloating, or persistent headache. Progesterone is not prescribed during pregnancy (it is already high). Stop and seek care for severe allergic symptoms.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Progesterone educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Progesterone Capsules?
Taken by mouth, once a day, at bedtime. The starting prescription is 1 capsule (50 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Progesterone Capsules come in?
The pharmacy carries 8: 50 mg, 75 mg, 100 mg, 150 mg, 175 mg, 200 mg, 250 mg, 300 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why is progesterone mandatory with estrogen?
Estrogen thickens the endometrium (uterine lining). Without progesterone, unopposed estrogen significantly raises endometrial cancer risk. Progesterone prevents this by shedding the thickened lining each month or quarter (depending on your dosing schedule). If your uterus was surgically removed (hysterectomy), progesterone is not needed.
Can I skip progesterone if my symptoms improve on estrogen alone?
No. Progesterone is mandatory with estrogen if you have a uterus. The protection is about cancer prevention, not symptom relief. Stopping progesterone while using estrogen significantly raises endometrial cancer risk. Your physician does not recommend this.
Does progesterone cause weight gain?
Some patients report mild bloating or water retention, but true weight gain is uncommon. If you notice significant weight gain, tell your physician. You may adjust dose, timing, or form.
Why do I take progesterone in the evening?
Progesterone causes drowsiness in many patients. Evening dosing helps you sleep and avoids daytime sedation. However, if you experience drowsiness, tell your physician, they may adjust timing or dose.
Progesterone, the uterine guardian.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
WHI Steering Committee: Risks and benefits of estrogen plus progestin in healthy postmenopausal women.
JAMA, 2002 - 2
KEEPS Investigators: The Kronos Early Estrogen Prevention Study (KEEPS).
Menopause, 2016
Progesterone Capsules (Micronized)from $69/mo