Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Taken by mouth · Once a day
AdrenalMemoryCognitive support
Pregnenolone Capsules
Bioidentical pregnenolone, the top of the adrenal cascade, for cognitive support and adrenal function. Take once daily. Research-stage cognitive benefits emerging.
- Bioidentical pregnenolone
- Top of the adrenal cascade
- Studied for memory and cognition
- Monthly$89/mo
- Every 3 months$207 billed up front$69/mo
- Every 6 monthsBest value$354 billed up front$59/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strength
- 25 mg
What is pregnenolone?
(pregnenolone)
Pregnenolone is the first hormone your body makes from cholesterol in your adrenal glands. It is a precursor to DHEA, progesterone, and ultimately testosterone and estrogen. Pregnenolone is studied for memory, cognitive function, and stress resilience. Some research suggests it may support mental clarity, particularly in aging.
What's in it
- PregnenolonePrecursor of steroid hormones
Top precursor
the first adrenal hormone, parent to DHEA and progesterone
Take 25-100 mg daily in the morning, as prescribed. Your physician may check pregnenolone levels to confirm dosing.
Is it right for you?
Who it's for
Adults with low pregnenolone on a blood test.
What sets it apart
The first hormone the body makes from cholesterol; all the others come after it.
Worth knowing before you start
Evidence for memory and mood is early. Take it in the morning.
Energy and vitality, rebuilt
Improved energy
many report steadier, deeper energy within weeks
Better mood and resilience
adrenal support often lifts mood and stress response
Enhanced vitality
supporting the adrenal cascade restores overall vigor
Adrenal backup
these hormones support your body's stress response system
How adrenal hormone therapy works
Day 1
A US-licensed physician reviews your energy, mood, and adrenal function goals, and discusses which adrenal hormone fits your needs.
1Week 1
Start your adrenal hormone in the morning. Most people do not feel immediate effects, this is about rebuilding your adrenal reserve over time.
2Weeks 2-4
Some patients notice improved energy or mood. Others take 6-8 weeks to notice change. Your physician monitors your response.
3Month 2-3
Check-in. Your physician reviews energy, mood, sleep quality, and any androgenic side effects (acne, hirsutism). Adjust dose if needed.
4Beyond
Continue your adrenal hormone as long as it helps. Your physician reassesses every 3-6 months and discusses long-term use.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (25 mg)
- How often
- Once a day
- When
- In the morning
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (25 mg) by mouth once daily in the morning for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of adrenal hormones
Pregnenolone levels decline with age. Animal models show pregnenolone supports memory and learning. Human studies are limited but growing, particularly for age-related cognitive decline.
Common side effects include mild dizziness, agitation if dosed too high, or insomnia if taken late in the day. Rare serious effects. Take in the morning. Not prescribed with hormone-sensitive cancers.
Learn moreImportant safety information and common side effects
DHEA, pregnenolone, and 7-Keto DHEA are prescription hormones that support adrenal function. Common effects include acne, facial hair in women (hirsutism from DHEA and pregnenolone), mood changes, insomnia if dosed too high or taken late in the day, and mild headache. DHEA and pregnenolone can convert to testosterone and estrogen, so they carry similar hormonal risks. 7-Keto DHEA does not convert to sex hormones and is generally well-tolerated. None are prescribed with hormone-sensitive cancers, and women taking DHEA or pregnenolone who can become pregnant must use reliable contraception. Tell your physician if you experience severe mood changes, severe acne, or significant sleep disruption.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Pregnenolone educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Pregnenolone Capsules?
Taken by mouth, once a day, in the morning. The starting prescription is 1 capsule (25 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Is pregnenolone FDA-approved?
No. Pregnenolone is not FDA-approved for any indication. It is compounded off-label at your physician's discretion, typically for cognitive or adrenal support. Evidence in humans is limited compared to animal studies.
Do adrenal hormones give you energy immediately?
No. These are hormones your body slowly converts to other hormones and neurotransmitters. Effects develop gradually over weeks to months. Some people feel changes in energy and mood within 2-4 weeks; others take 8-12 weeks. Patience is essential.
Will I get acne on DHEA or pregnenolone?
Some people do, particularly at higher doses. This is because both can convert to testosterone, which stimulates oil production. If acne develops, tell your physician. You may lower the dose, switch to 7-Keto DHEA (which does not convert to sex hormones), or try a different form.
Can I use adrenal hormones long-term?
Yes, but your physician monitors you regularly. Adrenal hormones work best with good sleep, nutrition, and stress management. Your physician reassesses every 3-6 months to ensure long-term benefit and safety.
Adrenal vitality, restored.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
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7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
from $79/mo
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
DHEA replacement therapy: a comprehensive review.
Semin Reprod Med, 2009 - 2
Pregnenolone: mechanisms of action and therapeutic potential in aging.
Neurobiol Aging, 2014
Pregnenolone Capsulesfrom $59/mo