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Kyzatrex
Kyzatrex (testosterone undecanoate, oral, FDA-approved): the first and only FDA-approved oral testosterone. Controlled substance (Schedule III). Taken with meals, twice daily. Blood pressure monitoring mandatory.
- FDA-approved; meets US pharmaceutical standards
- No injections needed; oral twice daily
- Steady testosterone levels without peaks and troughs
- Monthly$299/mo
- Every 3 months$807 billed up front$269/mo
- Every 6 monthsBest value$1,434 billed up front$239/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Twice a day
- Each shipment
- 1 bottle
- Strength
- 200 mg (1 Bottle, 120 Capsules)
What is Kyzatrex?
(KY-za-trex)
Kyzatrex is testosterone undecanoate (TU) in oral form, approved by the FDA in 2018. It is the first and only FDA-approved oral testosterone therapy. Taken with meals (food increases absorption 5-fold), typical dose 237–474 mg twice daily. It is a controlled substance (Schedule III), so your physician and pharmacy must handle it accordingly. Kyzatrex delivers steady testosterone without injections, but requires careful dosing and blood pressure monitoring.
What's in it
- KyzatrexReplaces low testosterone
FDA-approved
oral testosterone undecanoate; controlled substance (Sched III)
Kyzatrex is the only FDA-approved oral testosterone. It must be taken with food for proper absorption. Blood pressure can rise significantly; monitoring is mandatory. Liver function tests required before and during use.
Is it right for you?
Who it's for
Men with low testosterone who want an FDA-approved capsule and no needles or gels.
What sets it apart
Testosterone undecanoate by mouth, absorbed through the lymph instead of the liver.
Worth knowing before you start
Take it with food, twice a day. It can raise blood pressure: check yours at three weeks.
What to expect
Sustained energy and libido
steady daily testosterone supports mood and sexual function
Improved muscle and strength
testosterone builds lean mass over weeks and months
Lab-monitored safety
hematocrit, PSA, BP tracked at every visit
Close physician oversight
oral therapy requires careful management of absorption and dose
How oral testosterone works
Day 1
US-licensed physician reviews your symptoms, medical history, and testosterone goals. Blood pressure and baseline labs (testosterone, hematocrit, PSA, liver function) are obtained.
1Week 1
Start oral testosterone (Kyzatrex with meals, sublingual, or troches). No needles, no daily patch. Daily or twice-daily dosing provides steady testosterone.
2Week 4
Blood work checks testosterone level. If low, dose is increased. If target is reached, dose is maintained.
3Month 2–3
Follow-up labs (testosterone, hematocrit, PSA, liver function, blood pressure). Symptoms like energy, mood, libido, and erectile function are reviewed.
4Beyond
Testosterone monitored every 3–6 months; hematocrit and PSA yearly. Blood pressure checked every visit. Dose adjusted as needed to keep testosterone in target range.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (200 mg)
- How often
- Twice a day
- Each shipment
- 1 bottle
- Pharmacy label
- Take 1 capsule (200 mg) by mouth twice daily with food for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Twice a day
The science of oral testosterone
Testosterone undecanoate is absorbed in the lymphatic system when taken with fat-containing meals, bypassing first-pass liver metabolism. This allows effective oral dosing, unlike testosterone base (which is destroyed in the stomach).
Kyzatrex delivers steady testosterone levels in line with the Endocrine Society guideline for testosterone therapy. Polycythemia (high red blood cell count) and blood pressure elevation are the main monitoring concerns.
Learn moreImportant safety information and common side effects
Oral testosterone (Kyzatrex, sublingual, troches) carries the same risks as all testosterone therapy: elevated hematocrit (polycythemia), blood pressure rise, PSA elevation, reduced fertility, and clotting concerns. Kyzatrex is FDA-approved; sublingual and troches are compounded off-label. Blood pressure must be monitored every 3–6 months; hematocrit checked at baseline and every 6–12 months. Liver function tests (AST, ALT) required before and during use. Tell your physician about high blood pressure, blood clotting disorders, heart disease, or PSA concerns. Stop and seek care for chest pain, shortness of breath, leg swelling, or signs of stroke.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Kyzatrex educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Kyzatrex?
Taken by mouth, twice a day. The starting prescription is 1 capsule (200 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 bottle at the starting strength, shipped to your door from a licensed US pharmacy.
Is it a controlled substance?
Yes. The law requires a live video visit with the physician before it can be prescribed.
Why do I need to take Kyzatrex with meals?
Testosterone undecanoate (TU) is lipophilic (fat-soluble). When you take it with a meal containing fat, it is absorbed into the lymphatic system and delivered into the bloodstream, bypassing the liver. Without food, absorption is poor and unreliable. Meals with 20+ grams of fat are ideal.
Which oral testosterone is best, Kyzatrex or troches?
Kyzatrex is FDA-approved and pharmaceutical-grade; sublingual and troches are compounded off-label. Kyzatrex must be taken with meals (essential for absorption). Sublingual and troches offer flexibility and faster adjustments. Your physician chooses based on your preference, absorption, and response.
Will my blood pressure go up on oral testosterone?
Many men see a small rise in blood pressure on testosterone therapy (oral, injection, or topical). Some have no change. Check your BP at baseline and every 3–6 months. If it rises >10 mmHg, your physician may adjust testosterone dose, add a BP medication, or recommend lifestyle changes.
Can I switch from injections to oral testosterone?
Yes. If you have been on injections, your physician can transition you to oral testosterone. Your dose may change because absorption is different. Blood work at 4–6 weeks confirms the dose is right.
How long until I feel effects from oral testosterone?
Many men notice improved energy, mood, and libido within 2–4 weeks. Muscle and strength gains take 4–12 weeks. Erectile function often improves within 2–8 weeks.
Steady testosterone, daily oral dosing.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Kyzatrex (testosterone undecanoate) oral formulation: pharmacokinetics and clinical efficacy.
J Clin Endocrinol Metab, 2018 - 2
Sublingual and buccal testosterone delivery: routes of administration for testosterone therapy.
Endocrine Rev, 2018
Kyzatrexfrom $239/mo