Acne Cream
Triple-action topical for acne: antibiotic (clindamycin + erythromycin) and antifungal (ketoconazole). Covers bacterial and fungal acne.
Cream
from $139/mo
Applied to the skin · Once a day
HydrationLightweightDaily
HydroTone Gel
HydroTone gel: lightweight hydrating gel with humectants and ceramides. Mattifying for oily skin; hydrating without heaviness.
- Lightweight hydration without occlusion
- Ceramides and peptides support barrier
- Suitable for oily to combination skin
- Monthly$129/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strength
- 4 / 2 / 1 / 0.2%
What is HydroTone?
(humectant + ceramide hydrating gel)
HydroTone is a fast-absorbing gel with humectants (glycerin, hyaluronic acid) to draw moisture in, plus ceramides and peptides to support the skin barrier. It hydrates without the heaviness of creams, making it ideal for oily or combination skin. Use morning and night.
What's in it
- Niacinamide4%Evens tone, calms redness
- Dexpanthenol2%Conditions and hydrates
- Vitamin E1%Antioxidant, protects the barrier
- Hyaluronic Acid0.2%Holds water in the skin
Lightweight
hydration for oily to combination skin; no greasy feel
Can be layered under or over other treatments. Pairs well with actives like tretinoin or salicylic acid.
Is it right for you?
Who it's for
People with irritated or dry skin from retinoids or peels.
What sets it apart
No drug actives: niacinamide, panthenol, vitamin E and hyaluronic acid.
Worth knowing before you start
Use it in the morning when you use a retinoid at night.
What to expect
Improved radiance
skin brightness and clarity build over weeks
No irritation
all four are gentle enough for daily use
Firmness over time
peptides and collagen support strengthen skin
Targeted benefits
LuminEye for eyes, HydroTone for hydration, etc.
How supportive skincare works
Week 1
Start with one or all four depending on your skin needs. All are gentle and safe to layer.
1Week 2–4
Skin feels more hydrated. Subtle radiance improvements. No irritation.
2Month 2–3
Fine lines appear softer. Dark circles under eyes less noticeable. Skin tone more even.
3Month 3–6+
Cumulative antioxidant and peptide benefits compound. Skin appears firmer, brighter, more resilient.
4
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- affected area
- Dose
- 1 pump
- How often
- Once a day
- Each shipment
- 1 tube
- Pharmacy label
- Apply 1 pump to the affected area, morning or evening, for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of supportive skincare
Humectants pull moisture into the stratum corneum. Ceramides reinforce barrier lipid structure. Peptides support natural hydration.
Dermatologically recommended for oily, acne-prone, and combination skin. Does not clog pores or interfere with acne treatment.
Learn moreImportant safety information and common side effects
All four products are gentle, non-irritating, and suitable for daily use. No sun sensitivity or downtime. Safe during pregnancy after consultation. No contraindications with other treatments. Tell your physician if you have sensitivity to any ingredient (vitamin C, peptides, etc.). These are supportive skincare, not active treatments; they complement tretinoin, acids, and other prescription options. No adverse effects reported at standard doses.
Every plan includes
- Personalized, physician-guided plan
- Monthly plan
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
HydroTone gel educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use HydroTone Gel?
Applied to the skin, once a day. The starting prescription is 1 pump each time. Your physician sets your own dose and it is printed on your label.
What exactly is in it?
Niacinamide 4%, Dexpanthenol 2%, Vitamin E 1%, Hyaluronic Acid 0.2%.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Can I use HydroTone instead of a moisturizer?
If you have oily skin, yes, it provides sufficient hydration without occlusion. If you have dry skin, layer it over a richer cream or use before an oil-based serum.
Can I use all four together?
Yes. Apply in order: GHK-Cu cream + Vital C5 in morning, HydroTone as hydrating layer, LuminEye under eyes. At night, use GHK-Cu again. They layer well.
Can I use these with active treatments like tretinoin?
Yes. Use actives at night; these in morning or as base layers. They support and protect your skin while tretinoin accelerates renewal.
How long before I see results?
Immediate: improved hydration and texture. At 4-8 weeks: brightening and firmness. At 12 weeks: noticeable anti-aging benefit. Results compound.
Are these sufficient anti-aging alone?
These are maintenance and support. For significant wrinkle reduction or dark spot removal, combine with active treatments (tretinoin, hydroquinone, etc.). Alone, these prevent aging and support radiance.
Radiance built on solid support.
Acne Cream with Tretinoin
Acne treatment combining antibiotics (clindamycin/erythromycin/ketoconazole) with tretinoin for faster clearance and post-acne healing.
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Brightening Cream
Stronger prescription cream for stubborn melasma and dark spots: hydroquinone 6% with tretinoin, hydrocortisone, kojic acid and vitamins C and E. A short course, usually up to 8 weeks.
Cream
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Clarity Cream
Acne and post-acne formula combining azelaic acid, niacinamide, clindamycin, and tretinoin. Anti-inflammatory and cell-renewing.
Cream
from $149/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Vitamin C and antioxidant stability: mechanisms and skincare delivery.
Cosmet Dermatol, 2015 - 2
Peptides in moisturizers: collagen stimulation and barrier support.
J Cosmet Dermatol, 2019
HydroTone Gelfrom $129/mo