Acne Cream
Triple-action topical for acne: antibiotic (clindamycin + erythromycin) and antifungal (ketoconazole). Covers bacterial and fungal acne.
Cream
from $139/mo
Applied to the skin · Once a day
AcnePost-inflammatoryRedness
Clarity Cream
Clarity: targets acne redness and post-inflammatory marks through niacinamide and calming botanicals. Reduces inflammation, speeds healing.
- Niacinamide reduces redness and sebum
- Calming botanicals speed skin healing
- Use alongside acne treatments for faster clearance
- Monthly$149/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Applied to the skin
- How often
- Once a day
- Each shipment
- 1 tube
- Strength
- 10 / 4 / 2 / 0.1%
What is Clarity?
(anti-inflammatory acne-care blend)
Clarity focuses on reducing the inflammatory component of acne and accelerating healing of post-inflammatory marks. Niacinamide decreases redness and regulates oil; calming botanicals (aloe, centella asiatica) speed skin repair. Use alongside acne cream or tretinoin to amplify results.
What's in it
- Azelaic Acid10%Unclogs pores, evens tone
- Niacinamide4%Evens tone, calms redness
- Clindamycin2%Antibiotic for acne bacteria
- Tretinoin0.1%Speeds skin renewal
Complementary
treatment to reduce acne redness and post-inflammatory marks
Reduces healing time; does not replace primary acne treatment. Best combined with salicylic acid or tretinoin.
Is it right for you?
Who it's for
Adults with acne and the marks it leaves.
What sets it apart
Four actives: azelaic acid, niacinamide, an antibiotic and a strong 0.1% tretinoin.
Worth knowing before you start
Start every other night. Peeling in the first weeks is expected.
What to expect
Initial breakout possible
normal with tretinoin; usually resolves by week 4
Patience required
acne improvement takes 4-8 weeks minimum
Steady improvement
new spots form less often; existing marks fade
Sun protection essential
tretinoin and doxycycline increase photosensitivity
How acne treatments work
Week 1
Start with acne cream or low-dose tretinoin. Mild irritation and initial breakout may occur (normal; hang on).
1Week 2–4
If using doxycycline, bacteria count decreases. Topical treatment continues; acne begins to flatten.
2Week 4–8
New comedones form less frequently. Redness fades. Results become visible.
3Month 2–3+
Acne significantly improved. Reduce oral antibiotic if prescribed. Continue topical treatment indefinitely at lower frequency for maintenance.
4
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Applied to the skin
- Where
- affected area
- Dose
- 1 to 2 pumps
- How often
- Once a day
- When
- At bedtime
- Each shipment
- 1 tube
- Pharmacy label
- Apply 1 to 2 pumps to the affected area at bedtime once daily, for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of acne treatments
Niacinamide and botanical extracts reduce inflammatory cytokines and support skin barrier repair, accelerating recovery from acne.
This is an adjunct to primary acne treatment, not a stand-alone cure. Most people use it with acne cream or tretinoin.
Learn moreImportant safety information and common side effects
Topical acne treatments are generally well tolerated; salicylic acid and tretinoin can cause dryness, peeling, and irritation, especially at first. Tretinoin is absolutely contraindicated in pregnancy. Doxycycline is an antibiotic; inform your physician of other medications or allergies, and avoid dairy and calcium supplements (they reduce absorption). Doxycycline increases sun sensitivity, so daily SPF 30+ is essential. Tell your physician about any isotretinoin use history (Accutane). Stop and seek care for severe irritation, signs of allergic reaction, or persistent worsening of acne.
Every plan includes
- Personalized, physician-guided plan
- Monthly plan
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Clarity cream educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Clarity Cream?
Applied to the skin, once a day, at bedtime. The starting prescription is 1 to 2 pumps each time. Your physician sets your own dose and it is printed on your label.
What exactly is in it?
Azelaic Acid 10%, Niacinamide 4%, Clindamycin 2%, Tretinoin 0.1%.
How much arrives in each shipment?
1 tube at the starting strength, shipped to your door from a licensed US pharmacy.
Do I need Clarity if I use acne cream or tretinoin?
Not essential, but it accelerates healing and reduces residual redness. If you scar easily or want to minimize marks, it is a worthwhile addition. Your physician recommends based on your acne severity.
Can I use all four treatments together?
No. Typical layering: salicylic acid or tretinoin topically, plus doxycycline orally if moderate/severe, plus Clarity for healing. You don't need all four. Your physician chooses a layered plan based on acne severity.
When do I know if a treatment is working?
Give topical treatments 4 weeks and oral antibiotics 8 weeks before deciding if they work. Acne cycles naturally; don't switch treatments too quickly. If no improvement after 8 weeks, your physician will adjust.
What if I develop antibiotic resistance?
Doxycycline courses are typically 3-6 months, then stopped to minimize resistance risk. Continuing topical treatment (tretinoin or salicylic acid) maintains results and prevents relapse.
Can I use acne treatments if I'm using other topicals?
Space them: tretinoin at night, vitamin C or niacinamide in morning. Avoid mixing tretinoin with benzoyl peroxide or retinol. Your physician advises on layering safely.
Clear skin through layered therapy.
Acne Cream with Tretinoin
Acne treatment combining antibiotics (clindamycin/erythromycin/ketoconazole) with tretinoin for faster clearance and post-acne healing.
Cream
from $139/mo
Brightening Cream
Stronger prescription cream for stubborn melasma and dark spots: hydroquinone 6% with tretinoin, hydrocortisone, kojic acid and vitamins C and E. A short course, usually up to 8 weeks.
Cream
from $149/mo
ClearTone Cream
Brightening and anti-inflammatory cream combining azelaic acid, hydroquinone, kojic acid, tranexamic acid, and niacinamide. For post-acne hyperpigmentation.
Cream
from $149/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Tretinoin in acne: efficacy, retinization, and long-term maintenance.
J Clin Aesthet Dermatol, 2017 - 2
Doxycycline in moderate acne: antibiotic and anti-inflammatory mechanisms.
Antibiotics, 2019
Clarity Creamfrom $149/mo