Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Used vaginally · Once a day
BioidenticalVaginal atrophyConvenient
Estradiol Vaginal Inserts
Bioidentical estradiol vaginal inserts for vaginal atrophy and dryness. Insert once daily or twice weekly. Solid tablet form, no cream to apply.
- Bioidentical estradiol
- Solid insert, no cream mess
- Effective local therapy for vaginal atrophy
- Monthly$179/mo
- Every 3 months$477 billed up front$159/mo
- Every 6 monthsBest value$834 billed up front$139/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Used vaginally
- How often
- Once a day
- Each shipment
- 4 inserts
- Strength
- 10 mcg (8 Inserts per package)
What are estradiol vaginal inserts?
(bioidentical estradiol tablets, vaginal)
Estradiol vaginal inserts are small, solid tablets of bioidentical estradiol placed directly into the vagina. They dissolve slowly, releasing estradiol to restore vaginal tissue health. Convenient, no cream application needed. Local effect with minimal systemic absorption at standard doses.
What's in it
- EstradiolEstrogen: eases menopause symptoms
Solid insert
bioidentical estradiol, vaginal tablet form
Insert one tablet daily (10 mcg) or twice weekly (25 mcg), as prescribed. Effects develop over 2-3 weeks.
Is it right for you?
Who it's for
Women who want vaginal estradiol without the mess of a cream.
What sets it apart
An FDA-approved 10 mcg insert: a tiny, fixed dose.
Worth knowing before you start
Insert it at bedtime so it stays in place.
Results you can feel
Hot flash relief
the most dramatic change from estrogen therapy
Better sleep and mood
as symptoms settle and hormone levels stabilize
Bone protection
estrogen slows bone loss at menopause
Steadier energy
many patients report clearer, more stable daily rhythms
How estradiol therapy works
Day 1
A US-licensed physician reviews your menopausal symptoms, history, and risk factors to determine the best form and dose for you.
1Weeks 1-2
Hot flashes and night sweats usually begin to ease within 1-4 weeks, depending on the form and dose.
2Month 1-2
Sleep quality improves, mood stabilizes. Your physician checks in and may adjust your dose or form based on symptom control.
3Month 3
Check-in. Your physician reviews your progress, any side effects, and confirms your ongoing plan.
4Beyond
Estradiol therapy is reassessed at least yearly. Your physician discusses continuing, adjusting, or stopping based on benefits and risks.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Used vaginally
- Dose
- one insert (10 mcg)
- How often
- Once a day
- When
- At bedtime
- Each shipment
- 4 inserts
- Pharmacy label
- Insert one insert (10 mcg) vaginally at bedtime once daily for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of bioidentical estradiol
Vaginal inserts provide steady, local estradiol delivery that restores moisture, elasticity, and blood flow to atrophic vaginal tissue.
Systemic absorption is minimal at standard doses. Your physician may monitor estradiol levels if you use the higher 25 mcg dose regularly or have hormone-sensitive conditions.
Learn moreImportant safety information and common side effects
Estradiol is a prescription hormone with real benefits and real risks. Common effects include breast tenderness, nausea, headache, bloating, and spotting. Estrogen therapy increases risk of blood clots, stroke, gallbladder disease, and, with a uterus, requires progesterone for endometrial protection. Not prescribed with breast cancer history, blood clots, unexplained vaginal bleeding, liver disease, or pregnancy. Smoking significantly raises clot and stroke risk. Seek immediate care for chest pain, shortness of breath, leg swelling, severe headache, or vision changes. Tell your physician about every medication.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Estradiol vaginal inserts educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use Estradiol Vaginal Inserts?
Used vaginally, once a day, at bedtime. The starting prescription is one insert (10 mcg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
4 inserts at the starting strength, shipped to your door from a licensed US pharmacy.
How do I insert this tablet?
Using your fingers or the supplied applicator, insert the tablet as far into the vagina as comfortably possible at the same time each day (or twice weekly, as prescribed). Wash your hands before and after. Some women prefer inserting just before bedtime.
Is estradiol really bioidentical?
Yes. Bioidentical means its chemical structure matches what your body made. FDA-approved estradiol (brand names like Estrace) and compounded estradiol are both bioidentical. The difference is regulatory oversight.
Should I take topical or oral estradiol?
Your physician helps you choose based on your symptoms, tolerance, and risk factors. Topical forms bypass first-pass liver metabolism and may carry lower clot risk. Oral forms are convenient but increase gallbladder and clot risk slightly more.
Do I need progesterone with estradiol?
If you have a uterus, yes. Estrogen thickens the uterine lining, and unopposed estrogen increases endometrial cancer risk significantly. Progesterone prevents this. After hysterectomy, estrogen alone is safe.
How long do I take estradiol?
That is a decision you and your physician make at every visit. Some women use it for a few years; others longer. Your physician discusses the ongoing balance of benefits and risks with you regularly.
Estradiol, your way.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Kronos Early Estrogen Prevention Study (KEEPS): cardiovascular and metabolic effects.
Menopause, 2016 - 2
The 2022 hormone therapy position statement of The North American Menopause Society.
Menopause, 2022
Estradiol Vaginal Insertsfrom $139/mo