Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Taken by mouth · Once a day
Men's healthFertilityTestosterone
Enclomiphene
An oral selective estrogen receptor modulator (SERM) that stimulates your body's own testosterone production and preserves fertility. Once-daily capsule for men who want testosterone support without suppressing sperm production.
- Raises LH and FSH so your body makes its own testosterone
- Preserves sperm production and testicular size, unlike external testosterone
- Convenient oral capsule, once daily, no injections
- Monthly$199/mo
- Every 3 months$447 billed up front$149/mo
- Every 6 monthsBest value$594 billed up front$99/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 90 capsules
- Strengths
- 2 options · 12.5–25 mg
What is enclomiphene?
(en-KLOM-i-feen)
Enclomiphene is the active form of clomiphene that binds to estrogen receptors in the brain, tricking the pituitary into increasing LH and FSH—the signals that tell your testes to make testosterone and sperm. Unlike testosterone replacement therapy, which shuts those signals down, enclomiphene keeps them alive. It is taken as a compounded oral capsule, typically 12.5 or 25 mg once daily.
What's in it
- Enclomiphene CitrateRaises your own testosterone signal
LH + FSH
the two pituitary hormones enclomiphene raises to stimulate natural testosterone production
Enclomiphene is off-label in the US; it is a SERM with evidence in hypogonadism. Your physician decides if it fits your goals and health.
Is it right for you?
Who it's for
Men who want enclomiphene in the 12.5 or 25 mg capsule.
What sets it apart
The same medicine as the other enclomiphene, in the two most used strengths.
Worth knowing before you start
Testosterone is checked again at six to eight weeks. The dose is adjusted from that result.
Results you can feel
Testosterone rises
your own body makes it, not external replacement
Sperm counts improve
or stay intact, unlike on external testosterone
Testicular function preserved
size and production stay active
Energy and mood
as testosterone levels normalize
How enclomiphene works
Day 1
A US-licensed physician reviews your testosterone levels, fertility goals, history and symptoms, and determines your starting dose (usually 12.5 or 25 mg daily).
1Weeks 1–4
Take one capsule daily. Your pituitary begins increasing LH and FSH, signaling your testes to produce testosterone. Most men feel the effects within two to four weeks.
2Month 2
A follow-up labs panel checks your testosterone, LH, FSH and estradiol. Your physician adjusts the dose if needed to keep levels steady and side effects minimal.
3Month 3
Ongoing monitoring. Your semen parameters may be checked if fertility is your goal. Your physician confirms the dose and any adjustments.
4Beyond
Enclomiphene runs as long as you need it. Your physician reviews labs and your response at least every 3–6 months.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (12.5 mg)
- How often
- Once a day
- Each shipment
- 90 capsules
- Pharmacy label
- Take 1 capsule (12.5 mg) by mouth once daily.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 25 mg
- 12.5 mg
The science of enclomiphene
Enclomiphene has been shown to increase testosterone, LH and FSH in men with hypogonadism, making it a valid option for those who want testosterone support while preserving their own production.
Men choosing enclomiphene often prioritize fertility preservation or the option to stop therapy later without the prolonged recovery that follows external testosterone. Your physician reviews your goals first.
Learn moreImportant safety information and common side effects
Enclomiphene is generally well tolerated. The most common side effects are mild: headache, nausea, blurred vision or temporary vision changes (stop immediately and report to your physician), mood changes, and rarely, blood clots or deep vein thrombosis. Because it stimulates the pituitary, it is not prescribed with a pituitary adenoma. It can raise estradiol; your physician monitors this with labs. Seek care immediately for leg swelling, chest pain, shortness of breath, or sudden vision loss. Tell your physician about every medication, especially estrogen blockers or other hormone treatments.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Enclomiphene educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Enclomiphene - Men?
Taken by mouth, once a day. The starting prescription is 1 capsule (12.5 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Enclomiphene - Men come in?
The pharmacy carries 2: 12.5 mg, 25 mg. Your physician chooses which one you get.
How much arrives in each shipment?
90 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why enclomiphene instead of testosterone?
Enclomiphene tells your body to make its own testosterone; external testosterone tells it to stop. Enclomiphene is chosen by men who want hormone support but need to keep sperm production intact, avoid testicular shrinkage, or preserve the ability to stop therapy easily. Your physician decides which fits you.
How is enclomiphene different from testosterone therapy?
Testosterone therapy replaces the hormone externally, which tells your body to stop making its own and shuts down LH and FSH. Enclomiphene stimulates those same signals, so your body keeps making testosterone while you take it. When you stop, your production doesn't need a long recovery period.
Do I need labs?
Yes. Your physician checks testosterone, LH, FSH and estradiol after your first 4–6 weeks, and then periodically to confirm your dose is working and staying safe. If fertility is your goal, semen parameters may be checked too.
What if I want to stop?
Stopping enclomiphene is simpler than stopping external testosterone because your own production never shut down. Your physician may taper the dose; testosterone levels typically return to your baseline within days or a few weeks.
Can I take it with other medications?
Tell your physician about every medication, especially estrogen blockers, tamoxifen, other SERMs, or any hormone treatments. Some combinations need dose adjustments or closer monitoring.
Testosterone, naturally.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
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7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
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Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone.
BJU Int, 2016 - 2
Enclomiphene citrate for the treatment of secondary male hypogonadism.
Expert Opin Pharmacother, 2016
Enclomiphenefrom $99/mo