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AdrenalCombinationEnergy
DHEA + Pregnenolone Capsules
Bioidentical DHEA plus pregnenolone, two adrenal precursors, in one capsule. Take once daily. Synergistic adrenal support.
- DHEA + pregnenolone in one capsule
- Two adrenal precursor hormones
- Synergistic adrenal support
- Monthly$89/mo
- Every 3 months$207 billed up front$69/mo
- Every 6 monthsBest value$354 billed up front$59/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strengths
- 3 options · 10–25 mg DHEA / 100 mg pregnenolone
What is DHEA + pregnenolone?
(two adrenal precursor hormones)
This combination delivers two upstream adrenal hormones: DHEA and pregnenolone. Pregnenolone is the first hormone made from cholesterol in your adrenals and is a precursor to both DHEA and progesterone. Together, they support the adrenal cascade from cholesterol to active hormones, providing comprehensive adrenal support for energy, mood, and sexual function.
What's in it
- DHEAPrecursor of sex hormones
- PregnenolonePrecursor of steroid hormones
Dual support
DHEA and pregnenolone, two adrenal precursors in one capsule
Take one capsule daily (DHEA 25-50 mg + pregnenolone 25-50 mg), as prescribed. Your physician may check hormone levels 4-6 weeks after starting.
Is it right for you?
Who it's for
Adults low in both DHEA and pregnenolone on a blood test.
What sets it apart
Two precursors in one capsule: pregnenolone sits one step above DHEA in the hormone chain.
Worth knowing before you start
Take it in the morning; pregnenolone can be stimulating.
Energy and vitality, rebuilt
Improved energy
many report steadier, deeper energy within weeks
Better mood and resilience
adrenal support often lifts mood and stress response
Enhanced vitality
supporting the adrenal cascade restores overall vigor
Adrenal backup
these hormones support your body's stress response system
How adrenal hormone therapy works
Day 1
A US-licensed physician reviews your energy, mood, and adrenal function goals, and discusses which adrenal hormone fits your needs.
1Week 1
Start your adrenal hormone in the morning. Most people do not feel immediate effects, this is about rebuilding your adrenal reserve over time.
2Weeks 2-4
Some patients notice improved energy or mood. Others take 6-8 weeks to notice change. Your physician monitors your response.
3Month 2-3
Check-in. Your physician reviews energy, mood, sleep quality, and any androgenic side effects (acne, hirsutism). Adjust dose if needed.
4Beyond
Continue your adrenal hormone as long as it helps. Your physician reassesses every 3-6 months and discusses long-term use.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (10 mg DHEA / 50 mg pregnenolone)
- How often
- Once a day
- When
- In the morning
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (10 mg DHEA / 50 mg pregnenolone) by mouth once daily in the morning for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 25 mg / 100 mg
- 25 mg / 25 mg
- 10 mg / 50 mg
The science of adrenal hormones
Pregnenolone is the starting point for all adrenal and gonadal hormone synthesis. Combining DHEA and pregnenolone provides dual-level support of the adrenal cascade.
Side effects may include acne, mood changes, or insomnia if taken too late in the day. Some women experience hirsutism. Not prescribed with hormone-sensitive cancers. Take in the morning to avoid sleep disruption.
Learn moreImportant safety information and common side effects
DHEA, pregnenolone, and 7-Keto DHEA are prescription hormones that support adrenal function. Common effects include acne, facial hair in women (hirsutism from DHEA and pregnenolone), mood changes, insomnia if dosed too high or taken late in the day, and mild headache. DHEA and pregnenolone can convert to testosterone and estrogen, so they carry similar hormonal risks. 7-Keto DHEA does not convert to sex hormones and is generally well-tolerated. None are prescribed with hormone-sensitive cancers, and women taking DHEA or pregnenolone who can become pregnant must use reliable contraception. Tell your physician if you experience severe mood changes, severe acne, or significant sleep disruption.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
DHEA + pregnenolone combination educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take DHEA / Pregnenolone Capsules?
Taken by mouth, once a day, in the morning. The starting prescription is 1 capsule (10 mg DHEA / 50 mg pregnenolone) each time. Your physician sets your own dose and it is printed on your label.
What strengths does DHEA / Pregnenolone Capsules come in?
The pharmacy carries 3: 10 mg / 50 mg, 25 mg / 100 mg, 25 mg / 25 mg. Your physician chooses which one you get.
What exactly is in it?
DHEA, Pregnenolone.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Why combine DHEA and pregnenolone?
Pregnenolone is the top of the adrenal hormone cascade, while DHEA is downstream. Together, they support the entire pathway from cholesterol to active hormones. Some patients respond better to the combination than to either hormone alone.
Do adrenal hormones give you energy immediately?
No. These are hormones your body slowly converts to other hormones and neurotransmitters. Effects develop gradually over weeks to months. Some people feel changes in energy and mood within 2-4 weeks; others take 8-12 weeks. Patience is essential.
Will I get acne on DHEA or pregnenolone?
Some people do, particularly at higher doses. This is because both can convert to testosterone, which stimulates oil production. If acne develops, tell your physician. You may lower the dose, switch to 7-Keto DHEA (which does not convert to sex hormones), or try a different form.
Can I use adrenal hormones long-term?
Yes, but your physician monitors you regularly. Adrenal hormones work best with good sleep, nutrition, and stress management. Your physician reassesses every 3-6 months to ensure long-term benefit and safety.
Adrenal vitality, restored.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
DHEA replacement therapy: a comprehensive review.
Semin Reprod Med, 2009 - 2
Pregnenolone: mechanisms of action and therapeutic potential in aging.
Neurobiol Aging, 2014
DHEA + Pregnenolone Capsulesfrom $59/mo