Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Taken by mouth · Once a day
Men's healthFertilityFDA-approved
Clomiphene Tablets
FDA-approved clomiphene citrate 50 mg tablets, taken as half a tablet a day, to help men raise their own testosterone while preserving sperm production.
- Raises your own testosterone, keeps fertility
- FDA-approved generic tablet
- One half tablet a day
- Monthly$89/mo
- Every 3 months$207 billed up front$69/mo
- Every 6 monthsBest value$354 billed up front$59/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 15 tablets
- Strength
- 50 mg
What is clomiphene?
(KLOM-i-feen)
Clomiphene blocks estrogen's signal in the brain, so the pituitary releases more LH and FSH and the testes make more testosterone and sperm. In men it is used off-label.
What's in it
- Clomiphene CitrateRaises your own testosterone signal
LH + FSH
the two pituitary hormones clomiphene raises
Approved for women's fertility; used off-label in men with low testosterone who want to keep fertility.
Is it right for you?
Who it's for
Men who want clomiphene in its commercial 50 mg tablet.
What sets it apart
The FDA-approved tablet, made for women's fertility and used off-label in men, usually at half a tablet or less.
Worth knowing before you start
Clomiphene has two halves; one of them can cause mood swings. Enclomiphene is the half without it.
What to expect
Testicles stay healthy
size and function maintained on testosterone therapy
Sperm production continues
fertility potential preserved even during testosterone use
Faster recovery if you stop
endogenous testosterone and sperm return quickly when therapy ends
Lab monitoring required
LH, FSH, sperm count tracked to ensure response
How fertility preservation works
Day 1
US-licensed physician reviews your fertility goals, testicular health, and plans on testosterone therapy. Discussion of clomiphene vs. enclomiphene vs. hCG or combination.
1Week 1
Start clomiphene 25–50 mg daily or hCG 500–2,500 IU once weekly, depending on your plan. Baseline semen analysis or testicular ultrasound may be ordered to track changes.
2Weeks 4–8
LH and testosterone levels rise as clomiphene/hCG stimulates the testicles. Testicular function is preserved. Sperm production remains normal or improves.
3Month 2–3
Follow-up labs (LH, FSH, testosterone, sperm count). Dose adjusted if needed. If combining hCG with testosterone therapy, check testosterone levels.
4Beyond
Continue fertility support as long as you take testosterone therapy. If you stop testosterone, fertility usually returns within 3–6 months with continued clomiphene/hCG support.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- one half tablet (25 mg)
- How often
- Once a day
- Each shipment
- 15 tablets
- Pharmacy label
- Take one half tablet (25 mg) by mouth once daily for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of fertility preservation
Studies in men with secondary hypogonadism show clomiphene raises testosterone into the normal range in most, without lowering sperm counts.
Mood changes and visual disturbances can occur; stop and call your physician if you notice blurred vision or flashes of light.
Learn moreImportant safety information and common side effects
Clomiphene, enclomiphene, and hCG are prescribed off-label to preserve fertility and testicular function during testosterone therapy. Common side effects: mild headache, mood changes, abdominal discomfort. Clomiphene and enclomiphene may cause visual changes (blurred vision, floaters) in ~1% of users, report immediately if vision changes occur. hCG carries a small risk of ovarian hyperstimulation-like syndrome in some men if doses are very high. Tell your physician about prior fertility issues, current fertility plans, or any family history of gynecomastia or testicular disease. Stop and seek care for severe vision changes, severe headache, or testicular pain.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Clomiphene educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Clomiphene Tablets?
Taken by mouth, once a day. The starting prescription is one half tablet (25 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
15 tablets at the starting strength, shipped to your door from a licensed US pharmacy.
Tablet or compounded capsule?
The tablet is the FDA-approved product, split in half for a 25 mg dose. Compounded capsules come in exact doses. Your physician chooses.
Do I need clomiphene or hCG if I am on testosterone therapy?
Not always. If you are not concerned about fertility or testicular size, and your testosterone therapy is working well, neither is necessary. But if you want to preserve sperm production, prevent testicular atrophy, or plan a family in the future, your physician will recommend one.
Can I use clomiphene and hCG together?
Yes. Some physicians combine them for synergistic fertility preservation: clomiphene stimulates the pituitary (LH/FSH), hCG directly stimulates the testicles (testosterone/sperm). This combination is off-label but used clinically.
If I stop testosterone, will my fertility return?
Yes, usually within 3–6 months if you used clomiphene or hCG alongside testosterone. Without fertility support, recovery can take 6–12 months or longer. This is why fertility preservation on testosterone is important if you plan a family.
How often do I check sperm count or testicular health?
Initial baseline: before starting or at first visit. Then: every 3–6 months on clomiphene/hCG, or annually if on testosterone long-term. Semen analysis is the gold standard for sperm count; testicular ultrasound tracks size.
Family planning while on testosterone therapy.
Gonadorelin
A copy of the brain's own GnRH signal that keeps the testes producing testosterone and sperm, used alongside testosterone therapy and in fertility care. Prescribed and dosed by a licensed physician.
Injection
from $159/mo
7-Keto DHEA Capsules
7-Keto DHEA, a metabolite of DHEA that does not convert to testosterone or estrogen. Supports energy and metabolism without hormonal side effects.
Capsule
from $79/mo
Anastrozole - Men
A low-dose aromatase inhibitor for men on testosterone therapy whose blood work shows high estradiol, easing breast tenderness and water retention. Slow-release capsule, prescribed and dosed by a licensed physician.
Capsule
from $54/mo
The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Clomiphene citrate for men with testosterone deficiency: a review of pharmacology and outcomes.
Fertil Steril, 2016 - 2
Human chorionic gonadotropin in testosterone replacement therapy for hypogonadal men: a review.
J Androl, 2012
Clomiphene Tabletsfrom $59/mo