Estradiol Cypionate
Long-acting estradiol injection for menopause and perimenopause symptoms and for gender-affirming hormone therapy, given every one to two weeks. Prescribed and dosed by a licensed physician.
Injection
from $139/mo
Taken by mouth · Once a day
Fertility supportTesticular function
Clomiphene Capsules
Clomiphene (Clomid, off-label for men): selective estrogen receptor modulator that stimulates endogenous testosterone and preserves testicular function and fertility during hormone therapy.
- Stimulates pituitary and testicular testosterone production
- Maintains sperm production and testicular size on testosterone therapy
- Oral, daily dosing; preserves fertility potential
- Monthly$109/mo
- Every 3 months$267 billed up front$89/mo
- Every 6 monthsBest value$474 billed up front$79/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Taken by mouth
- How often
- Once a day
- Each shipment
- 30 capsules
- Strengths
- 2 options · 25–51 mg
What is clomiphene?
(KLO-mi-feen)
Clomiphene is a selective estrogen receptor modulator (SERM) that blocks negative feedback on the pituitary gland, triggering release of luteinizing hormone (LH). This stimulates the testicles to produce testosterone and sperm on their own, even while taking exogenous testosterone. It is used off-label in men to preserve testicular function and fertility. Typical dose: 25–50 mg daily or every other day.
What's in it
- Clomiphene CitrateRaises your own testosterone signal
Fertility-preserving
stimulates natural testosterone and sperm production
Clomiphene maintains testicular size and sperm count during testosterone therapy, useful for men planning family or concerned about fertility. It does not prevent the need for injectable testosterone if treating hypogonadism; it supplements exogenous therapy to maintain endogenous production.
Is it right for you?
Who it's for
Men with low testosterone who want to keep their fertility.
What sets it apart
It tells the brain to send more LH and FSH, so the testicles make more of their own testosterone.
Worth knowing before you start
Vision changes such as blur or flashes are a reason to stop and call your physician.
What to expect
Testicles stay healthy
size and function maintained on testosterone therapy
Sperm production continues
fertility potential preserved even during testosterone use
Faster recovery if you stop
endogenous testosterone and sperm return quickly when therapy ends
Lab monitoring required
LH, FSH, sperm count tracked to ensure response
How fertility preservation works
Day 1
US-licensed physician reviews your fertility goals, testicular health, and plans on testosterone therapy. Discussion of clomiphene vs. enclomiphene vs. hCG or combination.
1Week 1
Start clomiphene 25–50 mg daily or hCG 500–2,500 IU once weekly, depending on your plan. Baseline semen analysis or testicular ultrasound may be ordered to track changes.
2Weeks 4–8
LH and testosterone levels rise as clomiphene/hCG stimulates the testicles. Testicular function is preserved. Sperm production remains normal or improves.
3Month 2–3
Follow-up labs (LH, FSH, testosterone, sperm count). Dose adjusted if needed. If combining hCG with testosterone therapy, check testosterone levels.
4Beyond
Continue fertility support as long as you take testosterone therapy. If you stop testosterone, fertility usually returns within 3–6 months with continued clomiphene/hCG support.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Taken by mouth
- Dose
- 1 capsule (25 mg)
- How often
- Once a day
- Each shipment
- 30 capsules
- Pharmacy label
- Take 1 capsule (25 mg) by mouth once daily for 30 days.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
Strengths the pharmacy carries
- 25 mg
- 51 mg
The science of fertility preservation
Clomiphene blocks estrogen feedback in the hypothalamus and pituitary, allowing LH and FSH to rise. This stimulates Leydig cells (testosterone) and Sertoli cells (sperm production) in the testicles.
In off-label use for men on testosterone therapy, clomiphene preserves testicular function. Men stopping exogenous testosterone often recover endogenous production faster if they used clomiphene alongside therapy.
Learn moreImportant safety information and common side effects
Clomiphene, enclomiphene, and hCG are prescribed off-label to preserve fertility and testicular function during testosterone therapy. Common side effects: mild headache, mood changes, abdominal discomfort. Clomiphene and enclomiphene may cause visual changes (blurred vision, floaters) in ~1% of users, report immediately if vision changes occur. hCG carries a small risk of ovarian hyperstimulation-like syndrome in some men if doses are very high. Tell your physician about prior fertility issues, current fertility plans, or any family history of gynecomastia or testicular disease. Stop and seek care for severe vision changes, severe headache, or testicular pain.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
Clomiphene educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I take Clomiphene Capsules?
Taken by mouth, once a day. The starting prescription is 1 capsule (25 mg) each time. Your physician sets your own dose and it is printed on your label.
What strengths does Clomiphene Capsules come in?
The pharmacy carries 2: 25 mg, 51 mg. Your physician chooses which one you get.
How much arrives in each shipment?
30 capsules at the starting strength, shipped to your door from a licensed US pharmacy.
Will clomiphene restore my fertility if I am on testosterone therapy?
Clomiphene helps maintain sperm production and testicular function while you are on testosterone therapy by keeping LH and FSH elevated. It is most effective at preserving fertility if you plan to stop testosterone and return to natural production. If you stop therapy, fertility often returns within 3–6 months with clomiphene support.
Do I need clomiphene or hCG if I am on testosterone therapy?
Not always. If you are not concerned about fertility or testicular size, and your testosterone therapy is working well, neither is necessary. But if you want to preserve sperm production, prevent testicular atrophy, or plan a family in the future, your physician will recommend one.
Can I use clomiphene and hCG together?
Yes. Some physicians combine them for synergistic fertility preservation: clomiphene stimulates the pituitary (LH/FSH), hCG directly stimulates the testicles (testosterone/sperm). This combination is off-label but used clinically.
If I stop testosterone, will my fertility return?
Yes, usually within 3–6 months if you used clomiphene or hCG alongside testosterone. Without fertility support, recovery can take 6–12 months or longer. This is why fertility preservation on testosterone is important if you plan a family.
How often do I check sperm count or testicular health?
Initial baseline: before starting or at first visit. Then: every 3–6 months on clomiphene/hCG, or annually if on testosterone long-term. Semen analysis is the gold standard for sperm count; testicular ultrasound tracks size.
Family planning while on testosterone therapy.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Clomiphene citrate for men with testosterone deficiency: a review of pharmacology and outcomes.
Fertil Steril, 2016 - 2
Human chorionic gonadotropin in testosterone replacement therapy for hypogonadal men: a review.
J Androl, 2012
Clomiphene Capsulesfrom $79/mo