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Injected under the skin · Once a day
Research peptideSexual wellnessDesire
PT-141 (Bremelanotide)
PT-141 (bremelanotide): a melanocortin receptor agonist approved as Vyleesi for low sexual desire in women; used off-label in men. Subcutaneous injection 2–4 hours before sex. Common side effect: nausea. Not for uncontrolled high blood pressure.
- Approved for low sexual desire in women (Vyleesi); off-label in men
- On-demand dosing: inject 2–4 hours before sex, no daily pill needed
- Significant boost in sexual interest and arousal for many users
- Monthly$199/mo
- Every 3 months$537 billed up front$179/mo
- Every 6 monthsBest value$954 billed up front$159/mo
- Free, discreet shipping
- Licensed U.S. pharmacy
- Board-certified physicians
Disclaimer: Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Products are compounded by a licensed pharmacy. The FDA has not reviewed or approved compounded products for any use for safety, efficacy, or quality. Compounded medications are not FDA-approved brand-name products.
- How
- Injected under the skin
- How often
- Once a day
- Each shipment
- 1 vial
- Strength
- 2 mg/mL
What is PT-141?
(bremelanotide; melanocortin receptor agonist)
PT-141 (bremelanotide) is a melanocortin receptor agonist that increases sexual interest and arousal by activating receptors in the brain and body. It is FDA-approved as Vyleesi for women with hypoactive sexual desire disorder (HSDD). It is used off-label in men with low desire. Given as a subcutaneous injection 2–4 hours before sexual activity, PT-141 does not require daily dosing. Common side effect: nausea in the first hours (30–50% of users), often mild but sometimes requiring an antiemetic.
What's in it
- PT-141Acts on desire in the brain
FDA-approved
for women with HSDD (Vyleesi); off-label use in men
PT-141 works for sexual interest; arousal and response still depend on desire and stimulation. It is not prescribed with uncontrolled high blood pressure (melanocortin agonists can raise BP). Nausea is common but usually mild.
Is it right for you?
Who it's for
Adults whose problem is desire, not blood flow.
What sets it apart
It acts on desire in the brain. FDA-approved, as Vyleesi, for premenopausal women.
Worth knowing before you start
Nausea and flushing are common with the first doses. No more than one dose in 24 hours.
Results you can see and feel
Sun-free tan (Melanotan II)
gradual deepening of skin tone without UV
Sexual interest (PT-141)
on-demand boost in desire and arousal
Confidence
both improve appearance or intimacy confidence
Safety monitoring required
dermatology for Melanotan II, BP for PT-141
How melanocortin peptides work
Day 1
A US-licensed physician reviews your goals, medical history, and medications. For Melanotan II, a dermatologist clears your skin. For PT-141, your BP and cardiac history are checked.
1Week 1
For Melanotan II: small doses start the tanning process. For PT-141: first dose is tested privately to confirm tolerance and response.
2Week 2–4
Melanotan II: tan develops gradually over weeks. PT-141: sexual interest and arousal increase predictably on-demand.
3Month 2
Your physician checks in: Melanotan II users report on tanning progress and any mole changes (dermatology follow-up required). PT-141 users discuss sexual satisfaction and any side effects.
4Beyond
Melanotan II: ongoing dermatology checks are non-negotiable. PT-141: use as-needed; your physician reviews annually or if changes occur.
5
Individual results vary. Benefits reflect what Zepym Health members commonly report to their physician at check-ins; they are not the results of a clinical trial.
How you use it
This is the starting dose the pharmacy prints on the label. Your physician sets yours and adjusts it with you.
- How
- Injected under the skin
- Dose
- 10 units (0.2 mg)
- How often
- Once a day
- Each shipment
- 1 vial
- Pharmacy label
- Inject 10 units (0.2 mg) subcutaneously 2 to 4 hours before sexual activity. Do not use more than once in 24 hours or more than 8 doses per month. Discard any remaining medication.
A sample week
- M
- T
- W
- T
- F
- S
- S
Once a day
The science of melanocortin peptides
In trials of women with HSDD, PT-141 significantly increased sexual desire, arousal, and satisfaction compared to placebo. About 40% of women showed meaningful benefit.
Off-label use in men for low desire is growing; evidence is anecdotal and from small studies. Your physician discusses realistic expectations: PT-141 does not overcome relationship problems or performance anxiety alone.
Learn moreImportant safety information and common side effects
Melanotan II and PT-141 activate melanocortin receptors throughout the body, with different safety profiles. Melanotan II: melanoma risk is the primary concern; baseline skin exam with dermoscopy and regular mole checks are mandatory. Darkening of existing moles can make monitoring harder. PT-141: nausea is common (30–50%), usually mild; do not use with uncontrolled high blood pressure, recent MI, unstable angina, or severe heart disease. In men, priapism (erection lasting >4 hours) is rare but requires immediate care. Tell your physician about blood pressure medications, heart history, and any skin concerns. Stop and seek care for severe headache, chest pain, priapism, severe nausea, or signs of allergic reaction.
Every plan includes
- Personalized, physician-guided plan
- Monthly, 3-month and 6-month plans
- Dispensed by a US-licensed compounding pharmacy
- Unlimited protocol adjustments and messaging
- Ongoing support and check-ins
- Pause or cancel anytime
- Reviewed by our in-house physicians
How it works
1.Connect with a physician
Answer a few questions online and a US-licensed physician reviews your health, history and goals to make sure treatment is right for you. 100% online. No in-person visit required.
2.Get your discreet shipment
If approved, your treatment is compounded by a US-licensed, LegitScript-certified pharmacy, inspected for quality, and shipped discreetly to your door.
3.Receive continuous support
Start with one goal, then keep building over time. Unlimited physician messaging, easy refills and dose adjustments, all from the Zepym Health app.
PT-141 educational content reviewed by our physician
Scott Nass, MDDoctor of Medicine, board-certified in Family Medicine
Charles R. Drew University and David Geffen School of Medicine at UCLA. Family Medicine residency at Ventura County Medical Center.
Frequently asked questions
How do I use PT-141?
Injected under the skin, once a day. The starting prescription is 10 units (0.2 mg) each time. Your physician sets your own dose and it is printed on your label.
How much arrives in each shipment?
1 vial at the starting strength, shipped to your door from a licensed US pharmacy.
How do I use PT-141?
Inject subcutaneously 2–4 hours before anticipated sexual activity. Effects peak around 1–2 hours after injection and last several hours. One dose per 24 hours maximum. If nausea occurs, taking an anti-nausea medication (like ondansetron) 30 minutes before PT-141 helps some people. Eat a light meal beforehand; a full meal can delay effects.
How long until I see results?
Melanotan II: tan develops over 1–4 weeks of consistent dosing; deepens over months. PT-141: sexual effects appear within 1–2 hours of injection, peak around 2 hours, last several hours. Both require consistent use or dosing to maintain results.
What if I have side effects?
Melanotan II: darkening of moles, nausea, or erections in some men. Report all mole changes to your dermatologist immediately. PT-141: nausea is common (30–50%); anti-nausea medication beforehand helps. Rare: priapism in men (erection >4 hours)—seek emergency care. Stop immediately if any severe reaction occurs.
Can I use these with other medications?
Tell your physician about all medications, especially blood pressure drugs or cardiac medications. Some combinations need monitoring. Do not use Melanotan II with a personal or family history of melanoma without careful discussion with dermatology.
How long do I use these?
Melanotan II: as long as you want the tan; dermatology checks remain mandatory. PT-141: as-needed indefinitely, or until your sexual health goals change. Annual check-ins with your physician are recommended.
Appearance and intimacy, informed choice.
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The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. Individual results vary.
Sources
- 1
Melanotan II and its analogues as potential therapeutics for sexual dysfunction and other disorders.
Nat Rev Drug Discov, 2009 - 2
Bremelanotide for hypoactive sexual desire disorder in women: a randomized, placebo-controlled trial.
Obstet Gynecol, 2018
PT-141 (Bremelanotide)from $159/mo